Smart polymers as surface modifiers for bioanalytical devices and biomaterials : Theory and practice
(2016) In Russian Chemical Reviews 85(6). p.565-584- Abstract
Smart, or responsive polymers can reversibly change their state of aggregation, thus switching from water-soluble to insoluble state, in response to minor changes in temperature, pH or solvent composition. Grafting of these polymers to solid surfaces imparts the surfaces with controllable wettability and adsorption behaviour. The review summarizes the theoretical models and the results of physical measurements of the conformational transitions in grafted polymer chains and polymer brushes. Primary attention is paid to the grafting density and the length and spatial arrangement of grafted chains, the role of polystyrene, organosilane or alkanethiol sublayers and their effects on adsorption of proteins and adhesion of cells. The key... (More)
Smart, or responsive polymers can reversibly change their state of aggregation, thus switching from water-soluble to insoluble state, in response to minor changes in temperature, pH or solvent composition. Grafting of these polymers to solid surfaces imparts the surfaces with controllable wettability and adsorption behaviour. The review summarizes the theoretical models and the results of physical measurements of the conformational transitions in grafted polymer chains and polymer brushes. Primary attention is paid to the grafting density and the length and spatial arrangement of grafted chains, the role of polystyrene, organosilane or alkanethiol sublayers and their effects on adsorption of proteins and adhesion of cells. The key applications of grafted smart polymers such as cell culture and tissue engineering, cell and protein separation, biosensing and targeted drug delivery are surveyed. The bibliography includes 174 references.
(Less)
- author
- Ivanov, Alexander E. LU and Zubov, Vitaly P.
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Russian Chemical Reviews
- volume
- 85
- issue
- 6
- pages
- 20 pages
- publisher
- Turpion Ltd.
- external identifiers
-
- wos:000379356100002
- scopus:84978538415
- ISSN
- 0036-021X
- DOI
- 10.1070/RCR4567
- language
- English
- LU publication?
- yes
- id
- f4eb51e2-15ad-4799-a562-c2ab0b18c069
- date added to LUP
- 2017-02-07 12:16:34
- date last changed
- 2024-04-14 03:41:41
@article{f4eb51e2-15ad-4799-a562-c2ab0b18c069,
abstract = {{<p>Smart, or responsive polymers can reversibly change their state of aggregation, thus switching from water-soluble to insoluble state, in response to minor changes in temperature, pH or solvent composition. Grafting of these polymers to solid surfaces imparts the surfaces with controllable wettability and adsorption behaviour. The review summarizes the theoretical models and the results of physical measurements of the conformational transitions in grafted polymer chains and polymer brushes. Primary attention is paid to the grafting density and the length and spatial arrangement of grafted chains, the role of polystyrene, organosilane or alkanethiol sublayers and their effects on adsorption of proteins and adhesion of cells. The key applications of grafted smart polymers such as cell culture and tissue engineering, cell and protein separation, biosensing and targeted drug delivery are surveyed. The bibliography includes 174 references.</p>}},
author = {{Ivanov, Alexander E. and Zubov, Vitaly P.}},
issn = {{0036-021X}},
language = {{eng}},
number = {{6}},
pages = {{565--584}},
publisher = {{Turpion Ltd.}},
series = {{Russian Chemical Reviews}},
title = {{Smart polymers as surface modifiers for bioanalytical devices and biomaterials : Theory and practice}},
url = {{http://dx.doi.org/10.1070/RCR4567}},
doi = {{10.1070/RCR4567}},
volume = {{85}},
year = {{2016}},
}