Tissue specificity in nerve regeneration
(1986) In Scandinavian Journal of Plastic and Reconstructive Surgery 20(3). p.83-279- Abstract
In 1944 Weiss & Taylor presented experimental evidence against "neurotropism" in nerve regeneration. We used a silicone Y-chamber system to repeat some of those experiments. The proximal stump of transected rat sciatic nerve was introduced into the proximal inlet of the Y. One of the distal outlets was left empty, plugged or occupied by a tendon graft, the other outlet being occupied by a nerve graft. Analysis after 4 and 12 weeks showed in all cases a preferential or exclusive axonal growth towards the nerve piece. The results, indicating the existence of "tissue specificity", are contradictory to the results reported by Weiss & Taylor (30). The findings are discussed with respect to possible influence of humoral, cellular and... (More)
In 1944 Weiss & Taylor presented experimental evidence against "neurotropism" in nerve regeneration. We used a silicone Y-chamber system to repeat some of those experiments. The proximal stump of transected rat sciatic nerve was introduced into the proximal inlet of the Y. One of the distal outlets was left empty, plugged or occupied by a tendon graft, the other outlet being occupied by a nerve graft. Analysis after 4 and 12 weeks showed in all cases a preferential or exclusive axonal growth towards the nerve piece. The results, indicating the existence of "tissue specificity", are contradictory to the results reported by Weiss & Taylor (30). The findings are discussed with respect to possible influence of humoral, cellular and molecular factors associated with the distal nerve stump as well as the matrix, formed between both nerve segments.
(Less)
- author
- Lundborg, G LU ; Dahlin, L B LU ; Danielsen, N LU and Nachemson, A K
- organization
- publishing date
- 1986
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Axons, Cytological Techniques, Nerve Regeneration, Organ Specificity, Rats, Sciatic Nerve, Tendons, Journal Article, Research Support, Non-U.S. Gov't
- in
- Scandinavian Journal of Plastic and Reconstructive Surgery
- volume
- 20
- issue
- 3
- pages
- 83 - 279
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:3296138
- scopus:0022878254
- ISSN
- 0036-5556
- language
- English
- LU publication?
- yes
- id
- fd017e79-74ae-4fd3-8477-999fe36f3592
- date added to LUP
- 2017-10-13 14:10:03
- date last changed
- 2024-07-23 06:26:05
@article{fd017e79-74ae-4fd3-8477-999fe36f3592, abstract = {{<p>In 1944 Weiss & Taylor presented experimental evidence against "neurotropism" in nerve regeneration. We used a silicone Y-chamber system to repeat some of those experiments. The proximal stump of transected rat sciatic nerve was introduced into the proximal inlet of the Y. One of the distal outlets was left empty, plugged or occupied by a tendon graft, the other outlet being occupied by a nerve graft. Analysis after 4 and 12 weeks showed in all cases a preferential or exclusive axonal growth towards the nerve piece. The results, indicating the existence of "tissue specificity", are contradictory to the results reported by Weiss & Taylor (30). The findings are discussed with respect to possible influence of humoral, cellular and molecular factors associated with the distal nerve stump as well as the matrix, formed between both nerve segments.</p>}}, author = {{Lundborg, G and Dahlin, L B and Danielsen, N and Nachemson, A K}}, issn = {{0036-5556}}, keywords = {{Animals; Axons; Cytological Techniques; Nerve Regeneration; Organ Specificity; Rats; Sciatic Nerve; Tendons; Journal Article; Research Support, Non-U.S. Gov't}}, language = {{eng}}, number = {{3}}, pages = {{83--279}}, publisher = {{Taylor & Francis}}, series = {{Scandinavian Journal of Plastic and Reconstructive Surgery}}, title = {{Tissue specificity in nerve regeneration}}, volume = {{20}}, year = {{1986}}, }