Protein kinase C inhibition has only a transient growth arresting effect on in vitro regenerating mouse sensory neurons
(1999) In Neuroscience Letters 275(3). p.155-158- Abstract
Adult mice sensory ganglia were cultured in an extracellular matrix gel. Analyses of extending axons were made 48 h (long-term) or immediately (short-term) after addition of protein kinase inhibitors. Long- and short-term growth was insensitive to protein kinase A/G inhibition by HA-1004. Long-term protein kinase C inhibition by chelerythrine affected only certain, long axons. In the short-term virtually all axon growth was arrested, but largely recovered on the following day. When combined, the drugs inhibited all long- and short-term growth and largely prevented the recovery of the latter. The transient effect by chelerythrine, and the permanent inhibition after combination with HA-1004, suggests compensatory mechanisms, perhaps via... (More)
Adult mice sensory ganglia were cultured in an extracellular matrix gel. Analyses of extending axons were made 48 h (long-term) or immediately (short-term) after addition of protein kinase inhibitors. Long- and short-term growth was insensitive to protein kinase A/G inhibition by HA-1004. Long-term protein kinase C inhibition by chelerythrine affected only certain, long axons. In the short-term virtually all axon growth was arrested, but largely recovered on the following day. When combined, the drugs inhibited all long- and short-term growth and largely prevented the recovery of the latter. The transient effect by chelerythrine, and the permanent inhibition after combination with HA-1004, suggests compensatory mechanisms, perhaps via other kinases. Copyright (C) 1999 Elsevier Science Ireland Ltd.
(Less)
- author
- Wiklund, Peter LU and Ekström, Per LU
- organization
- publishing date
- 1999-11-19
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Chelerythrine chloride, Dorsal root ganglia, Growth cones, HA-1004, Protein kinase A, Protein kinase G
- in
- Neuroscience Letters
- volume
- 275
- issue
- 3
- pages
- 4 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:10580698
- scopus:0032754898
- ISSN
- 0304-3940
- DOI
- 10.1016/S0304-3940(99)00720-X
- language
- English
- LU publication?
- yes
- id
- 2b7fb55c-0453-40ae-8739-43a5a2b5bc2f
- date added to LUP
- 2016-12-07 14:47:27
- date last changed
- 2024-01-04 18:22:00
@article{2b7fb55c-0453-40ae-8739-43a5a2b5bc2f,
abstract = {{<p>Adult mice sensory ganglia were cultured in an extracellular matrix gel. Analyses of extending axons were made 48 h (long-term) or immediately (short-term) after addition of protein kinase inhibitors. Long- and short-term growth was insensitive to protein kinase A/G inhibition by HA-1004. Long-term protein kinase C inhibition by chelerythrine affected only certain, long axons. In the short-term virtually all axon growth was arrested, but largely recovered on the following day. When combined, the drugs inhibited all long- and short-term growth and largely prevented the recovery of the latter. The transient effect by chelerythrine, and the permanent inhibition after combination with HA-1004, suggests compensatory mechanisms, perhaps via other kinases. Copyright (C) 1999 Elsevier Science Ireland Ltd.</p>}},
author = {{Wiklund, Peter and Ekström, Per}},
issn = {{0304-3940}},
keywords = {{Chelerythrine chloride; Dorsal root ganglia; Growth cones; HA-1004; Protein kinase A; Protein kinase G}},
language = {{eng}},
month = {{11}},
number = {{3}},
pages = {{155--158}},
publisher = {{Elsevier}},
series = {{Neuroscience Letters}},
title = {{Protein kinase C inhibition has only a transient growth arresting effect on in vitro regenerating mouse sensory neurons}},
url = {{http://dx.doi.org/10.1016/S0304-3940(99)00720-X}},
doi = {{10.1016/S0304-3940(99)00720-X}},
volume = {{275}},
year = {{1999}},
}