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Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease

De Guio, François; Jouvent, Eric; Biessels, Geert Jan; Black, Sandra E.; Brayne, Carol; Chen, Christopher; Cordonnier, Charlotte; De Leeuw, Frank Eric; Dichgans, Martin and Doubal, Fergus, et al. (2016) In Journal of Cerebral Blood Flow and Metabolism 36(8). p.1319-1337
Abstract

Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on magnetic resonance imaging including: white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and brain volume. The aim is to summarize, for each marker, what is currently known about: (1) its reproducibility in studies... (More)

Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on magnetic resonance imaging including: white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and brain volume. The aim is to summarize, for each marker, what is currently known about: (1) its reproducibility in studies with a scan-rescan procedure either in single or multicenter settings; (2) the acquisition-related sources of variability; and, (3) the techniques used to minimize this variability. Based on the results, we discuss technical and other challenges that need to be overcome in order for these markers to be reliably used as outcome measures in future clinical trials. We also highlight the key points that need to be considered when designing multicenter magnetic resonance imaging studies of small vessel disease.

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publication status
published
subject
keywords
atrophy, brain volume, cerebral small vessel disease, lacunes, Magnetic resonance imaging, marker, microbleeds, perivascular spaces, repeatability, reproducibility, variability, white matter hyperintensities
in
Journal of Cerebral Blood Flow and Metabolism
volume
36
issue
8
pages
19 pages
publisher
Nature Publishing Group
external identifiers
  • Scopus:84982918689
ISSN
0271-678X
DOI
10.1177/0271678X16647396
language
English
LU publication?
yes
id
0d80b8b4-3be5-4df3-adb7-8a9052c8af99
date added to LUP
2016-09-01 15:44:28
date last changed
2016-10-30 04:49:36
@misc{0d80b8b4-3be5-4df3-adb7-8a9052c8af99,
  abstract     = {<p>Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on magnetic resonance imaging including: white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and brain volume. The aim is to summarize, for each marker, what is currently known about: (1) its reproducibility in studies with a scan-rescan procedure either in single or multicenter settings; (2) the acquisition-related sources of variability; and, (3) the techniques used to minimize this variability. Based on the results, we discuss technical and other challenges that need to be overcome in order for these markers to be reliably used as outcome measures in future clinical trials. We also highlight the key points that need to be considered when designing multicenter magnetic resonance imaging studies of small vessel disease.</p>},
  author       = {De Guio, François and Jouvent, Eric and Biessels, Geert Jan and Black, Sandra E. and Brayne, Carol and Chen, Christopher and Cordonnier, Charlotte and De Leeuw, Frank Eric and Dichgans, Martin and Doubal, Fergus and Duering, Marco and Dufouil, Carole and Duzel, Emrah and Fazekas, Franz and Hachinski, Vladimir and Ikram, M. Arfan and Linn, Jennifer and Matthews, Paul M. and Mazoyer, Bernard and Mok, Vincent and Norrving, Bo and O'Brien, John T. and Pantoni, Leonardo and Ropele, Stefan and Sachdev, Perminder and Schmidt, Reinhold and Seshadri, Sudha and Smith, Eric E. and Sposato, Luciano A. and Stephan, Blossom and Swartz, Richard H. and Tzourio, Christophe and Van Buchem, Mark and Van Der Lugt, Aad and Van Oostenbrugge, Robert and Vernooij, Meike W. and Viswanathan, Anand and Werring, David and Wollenweber, Frank and Wardlaw, Joanna M. and Chabriat, Hugues},
  issn         = {0271-678X},
  keyword      = {atrophy,brain volume,cerebral small vessel disease,lacunes,Magnetic resonance imaging,marker,microbleeds,perivascular spaces,repeatability,reproducibility,variability,white matter hyperintensities},
  language     = {eng},
  month        = {08},
  number       = {8},
  pages        = {1319--1337},
  publisher    = {ARRAY(0x80c81f8)},
  series       = {Journal of Cerebral Blood Flow and Metabolism},
  title        = {Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease},
  url          = {http://dx.doi.org/10.1177/0271678X16647396},
  volume       = {36},
  year         = {2016},
}