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Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers.

Halvarsson, Britta LU ; Anderson, Harald LU ; Bartuma, Katarina LU ; Lindmark, Gudrun LU and Nilbert, Mef LU (2008) In American Journal of Clinical Pathology 129(2). p.238-244
Abstract
Identification of sporadic mismatch repair (MMR)-defective colon cancers is increasingly demanded for decisions on adjuvant therapies. We evaluated clinicopathologic factors for the identification of these prognostically favorable tumors. Histopathologic features in 238 consecutive colon cancers were linked to MMR status based on immunostaining and BRAF mutation status.MMR defects were identified in 22.7% of the tumors, with 46 classified as sporadic. When the clinical parameters of age, sex, and proximal tumor location were combined with the morphologic features with the highest relative risks (RRs), eg, mucinous differentiation (RR, 9.0), tumor-infiltrating lymphocytes (RR, 7.5), absence of necrosis (RR, 7.5), and expanding growth... (More)
Identification of sporadic mismatch repair (MMR)-defective colon cancers is increasingly demanded for decisions on adjuvant therapies. We evaluated clinicopathologic factors for the identification of these prognostically favorable tumors. Histopathologic features in 238 consecutive colon cancers were linked to MMR status based on immunostaining and BRAF mutation status.MMR defects were identified in 22.7% of the tumors, with 46 classified as sporadic. When the clinical parameters of age, sex, and proximal tumor location were combined with the morphologic features with the highest relative risks (RRs), eg, mucinous differentiation (RR, 9.0), tumor-infiltrating lymphocytes (RR, 7.5), absence of necrosis (RR, 7.5), and expanding growth pattern (RR, 5.0) into a 7-factor index, the presence of at least 4 features identified the MMR-defective tumors with 92.3% sensitivity and 75.3% specificity and excluded 61.5% of the tumors from MMR testing. This clinicopathologic index thus successfully selects MMR-defective colon cancers. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Clinical Pathology
volume
129
issue
2
pages
238 - 244
publisher
American Society for Clinical Pathology
external identifiers
  • PMID:18208804
  • WOS:000252679700008
  • Scopus:40449121314
ISSN
1943-7722
DOI
10.1309/0PP5GDRTXUDVKAWJ
language
English
LU publication?
yes
id
5cbfa14a-c4cd-48fc-ab5f-abd43c786c78 (old id 1021232)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18208804?dopt=Abstract
date added to LUP
2008-02-11 12:05:51
date last changed
2016-10-13 04:30:49
@misc{5cbfa14a-c4cd-48fc-ab5f-abd43c786c78,
  abstract     = {Identification of sporadic mismatch repair (MMR)-defective colon cancers is increasingly demanded for decisions on adjuvant therapies. We evaluated clinicopathologic factors for the identification of these prognostically favorable tumors. Histopathologic features in 238 consecutive colon cancers were linked to MMR status based on immunostaining and BRAF mutation status.MMR defects were identified in 22.7% of the tumors, with 46 classified as sporadic. When the clinical parameters of age, sex, and proximal tumor location were combined with the morphologic features with the highest relative risks (RRs), eg, mucinous differentiation (RR, 9.0), tumor-infiltrating lymphocytes (RR, 7.5), absence of necrosis (RR, 7.5), and expanding growth pattern (RR, 5.0) into a 7-factor index, the presence of at least 4 features identified the MMR-defective tumors with 92.3% sensitivity and 75.3% specificity and excluded 61.5% of the tumors from MMR testing. This clinicopathologic index thus successfully selects MMR-defective colon cancers.},
  author       = {Halvarsson, Britta and Anderson, Harald and Bartuma, Katarina and Lindmark, Gudrun and Nilbert, Mef},
  issn         = {1943-7722},
  language     = {eng},
  number       = {2},
  pages        = {238--244},
  publisher    = {ARRAY(0x9da0f90)},
  series       = {American Journal of Clinical Pathology},
  title        = {Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers.},
  url          = {http://dx.doi.org/10.1309/0PP5GDRTXUDVKAWJ},
  volume       = {129},
  year         = {2008},
}