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Oestrogen treatment of constitutional tall stature in girls: is there a risk of thrombosis or bleeding?

Rask, Olof LU ; Nilsson, Karl Olof and Berntorp, Erik LU (2008) In Acta Pædiatrica 97(3). p.342-347
Abstract
Aim: To evaluate haemostatic effects and clinical outcome of oestrogen treatment of constitutionally tall stature in girls. Methods: We conducted a single-centre cohort study, 63 girls referred over a period of 15 years were investigated. The girls were given oestrogen treatment for constitutional tall stature at a median initial dose of 300 ug ethinyl estradiol/day and were consecutively examined for changes in coagulation. Medical records were retrospectively reviewed, additional data were collected at follow-up by blood sampling and interviews. Results: After 1 year of treatment, levels of antithrombin and von Willebrand factor (VWF) were significantly decreased (p < 0.001 and p = 0.015, respectively), whereas there was no... (More)
Aim: To evaluate haemostatic effects and clinical outcome of oestrogen treatment of constitutionally tall stature in girls. Methods: We conducted a single-centre cohort study, 63 girls referred over a period of 15 years were investigated. The girls were given oestrogen treatment for constitutional tall stature at a median initial dose of 300 ug ethinyl estradiol/day and were consecutively examined for changes in coagulation. Medical records were retrospectively reviewed, additional data were collected at follow-up by blood sampling and interviews. Results: After 1 year of treatment, levels of antithrombin and von Willebrand factor (VWF) were significantly decreased (p < 0.001 and p = 0.015, respectively), whereas there was no significant change in levels of plasminogen inhibitor type 1. No venous thromboembolism (VTE) or major side effects were observed. Genetic risk factors for thrombosis were present, as was expected. The mean height reduction was 5.5 cm. The height-reducing effect was inversely correlated with chronological age (r =-0.44, p < 0.01) and bone age (r =-0.61, p < 0.01). Conclusions: Changes in coagulation parameters occurred both towards pro- and anticoagulation. Treatment with high-dose ethinyl estradiol can successfully limit final height, and it is most effective when started at a younger bone age. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Pædiatrica
volume
97
issue
3
pages
342 - 347
publisher
Taylor & Francis
external identifiers
  • PMID:18298783
  • WOS:000253504300018
  • Scopus:42049103458
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2007.00635.x
language
English
LU publication?
yes
id
c86b0442-d97b-4770-8c36-f5aab55fb65c (old id 1041541)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18298783?dopt=Abstract
date added to LUP
2008-03-06 13:41:53
date last changed
2016-11-20 04:21:33
@misc{c86b0442-d97b-4770-8c36-f5aab55fb65c,
  abstract     = {Aim: To evaluate haemostatic effects and clinical outcome of oestrogen treatment of constitutionally tall stature in girls. Methods: We conducted a single-centre cohort study, 63 girls referred over a period of 15 years were investigated. The girls were given oestrogen treatment for constitutional tall stature at a median initial dose of 300 ug ethinyl estradiol/day and were consecutively examined for changes in coagulation. Medical records were retrospectively reviewed, additional data were collected at follow-up by blood sampling and interviews. Results: After 1 year of treatment, levels of antithrombin and von Willebrand factor (VWF) were significantly decreased (p &lt; 0.001 and p = 0.015, respectively), whereas there was no significant change in levels of plasminogen inhibitor type 1. No venous thromboembolism (VTE) or major side effects were observed. Genetic risk factors for thrombosis were present, as was expected. The mean height reduction was 5.5 cm. The height-reducing effect was inversely correlated with chronological age (r =-0.44, p &lt; 0.01) and bone age (r =-0.61, p &lt; 0.01). Conclusions: Changes in coagulation parameters occurred both towards pro- and anticoagulation. Treatment with high-dose ethinyl estradiol can successfully limit final height, and it is most effective when started at a younger bone age.},
  author       = {Rask, Olof and Nilsson, Karl Olof and Berntorp, Erik},
  issn         = {1651-2227},
  language     = {eng},
  number       = {3},
  pages        = {342--347},
  publisher    = {ARRAY(0x79eaa38)},
  series       = {Acta Pædiatrica},
  title        = {Oestrogen treatment of constitutional tall stature in girls: is there a risk of thrombosis or bleeding?},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2007.00635.x},
  volume       = {97},
  year         = {2008},
}