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Immigrants from the Middle-East have a different form of Type 2 diabetes compared with Swedish patients.

Glans, Forouzan LU ; Elgzyri, Targ LU ; Shaat, Nael LU ; Lindholm, Eero LU ; Apelqvist, Jan LU and Groop, Leif LU (2008) In Diabetic medicine : a journal of the British Diabetic Association 25(3). p.303-307
Abstract
AIMS: To compare the clinical characteristics of Type 2 diabetes (T2DM) between immigrants from the Middle-East and Swedish patients. METHODS: The study group included 450 consecutive patients with T2DM, 379 Swedish-born aged 61 +/- 12 years and 71 patients originally from the Middle-East aged 50 +/- 11 years from the diabetes clinic of Malmo University Hospital. RESULTS: Onset of diabetes had occurred 12 years earlier in the Middle-East immigrants compared with the Swedish-born patients (43 +/- 10 vs. 55 +/- 12 years, P < 0.001). Immigrants had lower fasting serum C-peptide [0.7 (0.1-2.6) vs. 0.9 (0.1-4.0) nmol/l, P = 0.013], lower homeostasis model assessment (HOMA)-beta[1.7 (0.1-9.1) vs. 2.7 (0.1-59.0), P = 0.010], lower HOMA-IR [0.4... (More)
AIMS: To compare the clinical characteristics of Type 2 diabetes (T2DM) between immigrants from the Middle-East and Swedish patients. METHODS: The study group included 450 consecutive patients with T2DM, 379 Swedish-born aged 61 +/- 12 years and 71 patients originally from the Middle-East aged 50 +/- 11 years from the diabetes clinic of Malmo University Hospital. RESULTS: Onset of diabetes had occurred 12 years earlier in the Middle-East immigrants compared with the Swedish-born patients (43 +/- 10 vs. 55 +/- 12 years, P < 0.001). Immigrants had lower fasting serum C-peptide [0.7 (0.1-2.6) vs. 0.9 (0.1-4.0) nmol/l, P = 0.013], lower homeostasis model assessment (HOMA)-beta[1.7 (0.1-9.1) vs. 2.7 (0.1-59.0), P = 0.010], lower HOMA-IR [0.4 (0.02-1.19) vs. 0.4 (0.01-2.8), P = 0.005] than the Swedish group. A first-degree family history of diabetes was reported in 61% of immigrants, compared with 47% of Swedish-born (P = 0.022). CONCLUSIONS: Immigrants from the Middle-East have an earlier onset, stronger family history and more rapid decline of pancreatic B-cell function than Swedish patients, suggesting that they have a different form of T2DM compared with Swedish patients. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetic medicine : a journal of the British Diabetic Association
volume
25
issue
3
pages
303 - 307
publisher
Wiley-Blackwell
external identifiers
  • PMID:18307458
  • WOS:000253609300009
  • Scopus:40049088818
ISSN
1464-5491
DOI
10.1111/j.1464-5491.2007.02366.x
language
English
LU publication?
yes
id
879baa84-5280-4c59-a94d-f7909f0cf52f (old id 1052992)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18307458?dopt=Abstract
date added to LUP
2008-04-01 11:47:41
date last changed
2016-10-27 16:12:25
@misc{879baa84-5280-4c59-a94d-f7909f0cf52f,
  abstract     = {AIMS: To compare the clinical characteristics of Type 2 diabetes (T2DM) between immigrants from the Middle-East and Swedish patients. METHODS: The study group included 450 consecutive patients with T2DM, 379 Swedish-born aged 61 +/- 12 years and 71 patients originally from the Middle-East aged 50 +/- 11 years from the diabetes clinic of Malmo University Hospital. RESULTS: Onset of diabetes had occurred 12 years earlier in the Middle-East immigrants compared with the Swedish-born patients (43 +/- 10 vs. 55 +/- 12 years, P &lt; 0.001). Immigrants had lower fasting serum C-peptide [0.7 (0.1-2.6) vs. 0.9 (0.1-4.0) nmol/l, P = 0.013], lower homeostasis model assessment (HOMA)-beta[1.7 (0.1-9.1) vs. 2.7 (0.1-59.0), P = 0.010], lower HOMA-IR [0.4 (0.02-1.19) vs. 0.4 (0.01-2.8), P = 0.005] than the Swedish group. A first-degree family history of diabetes was reported in 61% of immigrants, compared with 47% of Swedish-born (P = 0.022). CONCLUSIONS: Immigrants from the Middle-East have an earlier onset, stronger family history and more rapid decline of pancreatic B-cell function than Swedish patients, suggesting that they have a different form of T2DM compared with Swedish patients.},
  author       = {Glans, Forouzan and Elgzyri, Targ and Shaat, Nael and Lindholm, Eero and Apelqvist, Jan and Groop, Leif},
  issn         = {1464-5491},
  language     = {eng},
  number       = {3},
  pages        = {303--307},
  publisher    = {ARRAY(0xcfd3df0)},
  series       = {Diabetic medicine : a journal of the British Diabetic Association},
  title        = {Immigrants from the Middle-East have a different form of Type 2 diabetes compared with Swedish patients.},
  url          = {http://dx.doi.org/10.1111/j.1464-5491.2007.02366.x},
  volume       = {25},
  year         = {2008},
}