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Apolipoprotein M affecting lipid metabolism or just catching a ride with lipoproteins in the circulation?

Dahlbäck, Björn LU and Nielsen, Lars (2009) In Cellular and molecular life sciences : CMLS 66. p.559-564
Abstract
Apolipoprotein M (apoM) is a novel apolipoprotein found mainly in high-density lipoproteins (HDL). Its function is yet to be defined. ApoM (25 kDa) has a typical lipocalin beta-barrel fold and a hydrophobic pocket. Retinoids bind apoM but with low affinity and may not be the natural ligands. ApoM retains its signal peptide, which serves as a hydrophobic anchor to the lipoproteins. This prevents apoM from being lost in the urine. Approximately 5% of HDL carries an apoM molecule. ApoM in plasma (1 muM) correlates strongly with both low-density lipoprotein (LDL) and HDL cholesterol, suggesting a link to cholesterol metabolism. However, in casecontrol studies, apoM levels in patients with coronary heart disease (CHD) and controls were similar,... (More)
Apolipoprotein M (apoM) is a novel apolipoprotein found mainly in high-density lipoproteins (HDL). Its function is yet to be defined. ApoM (25 kDa) has a typical lipocalin beta-barrel fold and a hydrophobic pocket. Retinoids bind apoM but with low affinity and may not be the natural ligands. ApoM retains its signal peptide, which serves as a hydrophobic anchor to the lipoproteins. This prevents apoM from being lost in the urine. Approximately 5% of HDL carries an apoM molecule. ApoM in plasma (1 muM) correlates strongly with both low-density lipoprotein (LDL) and HDL cholesterol, suggesting a link to cholesterol metabolism. However, in casecontrol studies, apoM levels in patients with coronary heart disease (CHD) and controls were similar, suggesting apoM levels not to affect the risk for CHD in humans. Experiments in transgenic mice suggested apoM to have antiatherogenic properties; possible mechanisms include increased formation of pre-beta HDL, enhanced cholesterol mobilization from foam cells, and increased antioxidant properties. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cellular and molecular life sciences : CMLS
volume
66
pages
559 - 564
publisher
Birkhaüser
external identifiers
  • WOS:000263418300002
  • PMID:19153651
  • Scopus:60149087438
ISSN
1420-9071
DOI
10.1007/s00018-009-8764-8
language
English
LU publication?
yes
id
ae7a35b9-1a4d-4604-88d2-c1ba0cba6e14 (old id 1289559)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19153651?dopt=Abstract
date added to LUP
2009-02-04 10:59:50
date last changed
2016-10-27 15:25:08
@misc{ae7a35b9-1a4d-4604-88d2-c1ba0cba6e14,
  abstract     = {Apolipoprotein M (apoM) is a novel apolipoprotein found mainly in high-density lipoproteins (HDL). Its function is yet to be defined. ApoM (25 kDa) has a typical lipocalin beta-barrel fold and a hydrophobic pocket. Retinoids bind apoM but with low affinity and may not be the natural ligands. ApoM retains its signal peptide, which serves as a hydrophobic anchor to the lipoproteins. This prevents apoM from being lost in the urine. Approximately 5% of HDL carries an apoM molecule. ApoM in plasma (1 muM) correlates strongly with both low-density lipoprotein (LDL) and HDL cholesterol, suggesting a link to cholesterol metabolism. However, in casecontrol studies, apoM levels in patients with coronary heart disease (CHD) and controls were similar, suggesting apoM levels not to affect the risk for CHD in humans. Experiments in transgenic mice suggested apoM to have antiatherogenic properties; possible mechanisms include increased formation of pre-beta HDL, enhanced cholesterol mobilization from foam cells, and increased antioxidant properties.},
  author       = {Dahlbäck, Björn and Nielsen, Lars},
  issn         = {1420-9071},
  language     = {eng},
  pages        = {559--564},
  publisher    = {ARRAY(0x940f170)},
  series       = {Cellular and molecular life sciences : CMLS},
  title        = {Apolipoprotein M affecting lipid metabolism or just catching a ride with lipoproteins in the circulation?},
  url          = {http://dx.doi.org/10.1007/s00018-009-8764-8},
  volume       = {66},
  year         = {2009},
}