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Orthostatic hypotension in organic dementia: relationship between blood pressure, cortical blood flow and symptoms

Passant, Ulla LU ; Warkentin, Siegbert LU ; Karlson, S; Nilsson, Karin LU ; Edvinsson, Lars LU and Gustafson, Lars LU (1996) In Clinical autonomic research : official journal of the Clinical Autonomic Research Society 6(1). p.29-36
Abstract
Regional cerebral blood flow was measured in 35 patients with organic dementia (Alzheimer's disease, n = 13, vascular dementia, n = 17, frontotemporal dementia, n = 5) and orthostatic hypotension. Measurements were performed during supine rest and during head-up tilt (60 degrees). Despite marked blood pressure falls, few patients had symptoms of orthostatic hypotension. All three dementia groups had a decrease in regional cerebral blood flow in the frontal lobes during head-up tilt, but no change in mean hemispheric flow. All patients had a consistent drop in their systolic blood pressure upon head-up tilt, with a wide variation over time. The findings suggest that orthostatic hypotension needs to be considered, and actively sought for, in... (More)
Regional cerebral blood flow was measured in 35 patients with organic dementia (Alzheimer's disease, n = 13, vascular dementia, n = 17, frontotemporal dementia, n = 5) and orthostatic hypotension. Measurements were performed during supine rest and during head-up tilt (60 degrees). Despite marked blood pressure falls, few patients had symptoms of orthostatic hypotension. All three dementia groups had a decrease in regional cerebral blood flow in the frontal lobes during head-up tilt, but no change in mean hemispheric flow. All patients had a consistent drop in their systolic blood pressure upon head-up tilt, with a wide variation over time. The findings suggest that orthostatic hypotension needs to be considered, and actively sought for, in organic dementia as many patients may lack the typical symptoms of orthostatic hypotension, despite a marked fall in blood pressure. (Less)
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published
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Clinical autonomic research : official journal of the Clinical Autonomic Research Society
volume
6
issue
1
pages
29 - 36
external identifiers
  • Scopus:0029935468
language
English
LU publication?
yes
id
98d9cea5-3522-4bcf-b29f-ca695481a386 (old id 1296397)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed?term=Orthostatic%20hypotension%20in%20organic%20dementia%3A%20relationship%20between%20blood%20pressure%2C%20cortical%20blood%20flow%20and%20symptoms
date added to LUP
2012-12-12 14:48:23
date last changed
2016-04-16 12:43:11
@misc{98d9cea5-3522-4bcf-b29f-ca695481a386,
  abstract     = {Regional cerebral blood flow was measured in 35 patients with organic dementia (Alzheimer's disease, n = 13, vascular dementia, n = 17, frontotemporal dementia, n = 5) and orthostatic hypotension. Measurements were performed during supine rest and during head-up tilt (60 degrees). Despite marked blood pressure falls, few patients had symptoms of orthostatic hypotension. All three dementia groups had a decrease in regional cerebral blood flow in the frontal lobes during head-up tilt, but no change in mean hemispheric flow. All patients had a consistent drop in their systolic blood pressure upon head-up tilt, with a wide variation over time. The findings suggest that orthostatic hypotension needs to be considered, and actively sought for, in organic dementia as many patients may lack the typical symptoms of orthostatic hypotension, despite a marked fall in blood pressure.},
  author       = {Passant, Ulla and Warkentin, Siegbert and Karlson, S and Nilsson, Karin and Edvinsson, Lars and Gustafson, Lars},
  language     = {eng},
  number       = {1},
  pages        = {29--36},
  series       = {Clinical autonomic research : official journal of the Clinical Autonomic Research Society},
  title        = {Orthostatic hypotension in organic dementia: relationship between blood pressure, cortical blood flow and symptoms},
  volume       = {6},
  year         = {1996},
}