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Intraepidermal nerve fibre density at wrist level in diabetic and non-diabetic patients.

Thomsen, Niels LU ; Englund, Elisabet LU ; Thrainsdottir, Soley LU ; Rosén, Ingmar LU and Dahlin, Lars LU (2009) In Diabetic medicine : a journal of the British Diabetic Association 26(11). p.1120-1126
Abstract
Abstract Aims Myelinated nerve fibre pathology has been demonstrated at wrist level in diabetic patients. We examined if quantification of intra-epidermal nerve fibre density (IENFD) in hairy and glabrous skin at wrist level could detect signs of subclinical small nerve fibre neuropathy. Methods In 35 diabetic patients who were age and gender matched with 31 non-diabetic patients, punch biopsies were obtained in conjunction with surgical carpal tunnel release. Biopsies were immunostained with anti-protein gene product (PGP) 9.5. The IENFD was quantified using manual counting by light microscopy. Results We could not demonstrate significant differences in IENFD between diabetic or non-diabetic patients. Additionally, no differences were... (More)
Abstract Aims Myelinated nerve fibre pathology has been demonstrated at wrist level in diabetic patients. We examined if quantification of intra-epidermal nerve fibre density (IENFD) in hairy and glabrous skin at wrist level could detect signs of subclinical small nerve fibre neuropathy. Methods In 35 diabetic patients who were age and gender matched with 31 non-diabetic patients, punch biopsies were obtained in conjunction with surgical carpal tunnel release. Biopsies were immunostained with anti-protein gene product (PGP) 9.5. The IENFD was quantified using manual counting by light microscopy. Results We could not demonstrate significant differences in IENFD between diabetic or non-diabetic patients. Additionally, no differences were found between patients with Type 1 and Type 2 diabetes or in diabetic patients with and without neurophysiologic signs of mild peripheral neuropathy. However, the IENFD was significantly higher in hairy skin compared with glabrous skin. Furthermore, the IENFD was significantly higher in females than in males and correlated with age, but not with duration of diabetes or glycated haemoglobin (HbA(1c)). Conclusions In mild neuropathy no difference in IENFD at the wrist level could be detected between diabetic and non-diabetic patients. Independent of diabetes, we found IENFD to be higher in hairy skin compared with glabrous skin and higher in females than in males. These results must be taken into consideration when assessing small nerve fibre pathology in the upper extremity. Diabet. Med. 26, 1120-1126 (2009). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetic medicine : a journal of the British Diabetic Association
volume
26
issue
11
pages
1120 - 1126
publisher
Wiley-Blackwell
external identifiers
  • WOS:000271493900007
  • PMID:19929990
  • Scopus:70350786424
ISSN
1464-5491
DOI
10.1111/j.1464-5491.2009.02823.x
language
English
LU publication?
yes
id
08e3546f-ae32-4c39-ba16-5627a10fddea (old id 1511693)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19929990?dopt=Abstract
date added to LUP
2009-12-07 09:29:13
date last changed
2016-10-27 16:12:25
@misc{08e3546f-ae32-4c39-ba16-5627a10fddea,
  abstract     = {Abstract Aims Myelinated nerve fibre pathology has been demonstrated at wrist level in diabetic patients. We examined if quantification of intra-epidermal nerve fibre density (IENFD) in hairy and glabrous skin at wrist level could detect signs of subclinical small nerve fibre neuropathy. Methods In 35 diabetic patients who were age and gender matched with 31 non-diabetic patients, punch biopsies were obtained in conjunction with surgical carpal tunnel release. Biopsies were immunostained with anti-protein gene product (PGP) 9.5. The IENFD was quantified using manual counting by light microscopy. Results We could not demonstrate significant differences in IENFD between diabetic or non-diabetic patients. Additionally, no differences were found between patients with Type 1 and Type 2 diabetes or in diabetic patients with and without neurophysiologic signs of mild peripheral neuropathy. However, the IENFD was significantly higher in hairy skin compared with glabrous skin. Furthermore, the IENFD was significantly higher in females than in males and correlated with age, but not with duration of diabetes or glycated haemoglobin (HbA(1c)). Conclusions In mild neuropathy no difference in IENFD at the wrist level could be detected between diabetic and non-diabetic patients. Independent of diabetes, we found IENFD to be higher in hairy skin compared with glabrous skin and higher in females than in males. These results must be taken into consideration when assessing small nerve fibre pathology in the upper extremity. Diabet. Med. 26, 1120-1126 (2009).},
  author       = {Thomsen, Niels and Englund, Elisabet and Thrainsdottir, Soley and Rosén, Ingmar and Dahlin, Lars},
  issn         = {1464-5491},
  language     = {eng},
  number       = {11},
  pages        = {1120--1126},
  publisher    = {ARRAY(0x7ed4e28)},
  series       = {Diabetic medicine : a journal of the British Diabetic Association},
  title        = {Intraepidermal nerve fibre density at wrist level in diabetic and non-diabetic patients.},
  url          = {http://dx.doi.org/10.1111/j.1464-5491.2009.02823.x},
  volume       = {26},
  year         = {2009},
}