Intraepidermal nerve fibre density at wrist level in diabetic and non-diabetic patients.
Thomsen, Niels LU ; Englund, Elisabet LU
; Thrainsdottir, Soley
LU
; Rosén, Ingmar
LU
and Dahlin, Lars
LU
(2009)
In Diabetic Medicine: A journal of the British Diabetic Association
26(11).
p.1120-1126
- Abstract
- Abstract Aims Myelinated nerve fibre pathology has been demonstrated at wrist level in diabetic patients. We examined if quantification of intra-epidermal nerve fibre density (IENFD) in hairy and glabrous skin at wrist level could detect signs of subclinical small nerve fibre neuropathy. Methods In 35 diabetic patients who were age and gender matched with 31 non-diabetic patients, punch biopsies were obtained in conjunction with surgical carpal tunnel release. Biopsies were immunostained with anti-protein gene product (PGP) 9.5. The IENFD was quantified using manual counting by light microscopy. Results We could not demonstrate significant differences in IENFD between diabetic or non-diabetic patients. Additionally, no differences were... (More)
- Abstract Aims Myelinated nerve fibre pathology has been demonstrated at wrist level in diabetic patients. We examined if quantification of intra-epidermal nerve fibre density (IENFD) in hairy and glabrous skin at wrist level could detect signs of subclinical small nerve fibre neuropathy. Methods In 35 diabetic patients who were age and gender matched with 31 non-diabetic patients, punch biopsies were obtained in conjunction with surgical carpal tunnel release. Biopsies were immunostained with anti-protein gene product (PGP) 9.5. The IENFD was quantified using manual counting by light microscopy. Results We could not demonstrate significant differences in IENFD between diabetic or non-diabetic patients. Additionally, no differences were found between patients with Type 1 and Type 2 diabetes or in diabetic patients with and without neurophysiologic signs of mild peripheral neuropathy. However, the IENFD was significantly higher in hairy skin compared with glabrous skin. Furthermore, the IENFD was significantly higher in females than in males and correlated with age, but not with duration of diabetes or glycated haemoglobin (HbA(1c)). Conclusions In mild neuropathy no difference in IENFD at the wrist level could be detected between diabetic and non-diabetic patients. Independent of diabetes, we found IENFD to be higher in hairy skin compared with glabrous skin and higher in females than in males. These results must be taken into consideration when assessing small nerve fibre pathology in the upper extremity. Diabet. Med. 26, 1120-1126 (2009). (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1511693
- author
- Thomsen, Niels
LU
; Englund, Elisabet
LU
; Thrainsdottir, Soley
LU
; Rosén, Ingmar
LU
and Dahlin, Lars
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetic Medicine: A journal of the British Diabetic Association
- volume
- 26
- issue
- 11
- pages
- 1120 - 1126
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000271493900007
- pmid:19929990
- scopus:70350786424
- ISSN
- 1464-5491
- DOI
- 10.1111/j.1464-5491.2009.02823.x
- project
- Diabetic neuropathy and nerve compression in diabetes
- language
- English
- LU publication?
- yes
- id
- 08e3546f-ae32-4c39-ba16-5627a10fddea (old id 1511693)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19929990?dopt=Abstract
- date added to LUP
- 2016-04-04 09:12:43
- date last changed
- 2022-04-08 01:59:45
@article{08e3546f-ae32-4c39-ba16-5627a10fddea,
abstract = {{Abstract Aims Myelinated nerve fibre pathology has been demonstrated at wrist level in diabetic patients. We examined if quantification of intra-epidermal nerve fibre density (IENFD) in hairy and glabrous skin at wrist level could detect signs of subclinical small nerve fibre neuropathy. Methods In 35 diabetic patients who were age and gender matched with 31 non-diabetic patients, punch biopsies were obtained in conjunction with surgical carpal tunnel release. Biopsies were immunostained with anti-protein gene product (PGP) 9.5. The IENFD was quantified using manual counting by light microscopy. Results We could not demonstrate significant differences in IENFD between diabetic or non-diabetic patients. Additionally, no differences were found between patients with Type 1 and Type 2 diabetes or in diabetic patients with and without neurophysiologic signs of mild peripheral neuropathy. However, the IENFD was significantly higher in hairy skin compared with glabrous skin. Furthermore, the IENFD was significantly higher in females than in males and correlated with age, but not with duration of diabetes or glycated haemoglobin (HbA(1c)). Conclusions In mild neuropathy no difference in IENFD at the wrist level could be detected between diabetic and non-diabetic patients. Independent of diabetes, we found IENFD to be higher in hairy skin compared with glabrous skin and higher in females than in males. These results must be taken into consideration when assessing small nerve fibre pathology in the upper extremity. Diabet. Med. 26, 1120-1126 (2009).}},
author = {{Thomsen, Niels and Englund, Elisabet and Thrainsdottir, Soley and Rosén, Ingmar and Dahlin, Lars}},
issn = {{1464-5491}},
language = {{eng}},
number = {{11}},
pages = {{1120--1126}},
publisher = {{Wiley-Blackwell}},
series = {{Diabetic Medicine: A journal of the British Diabetic Association}},
title = {{Intraepidermal nerve fibre density at wrist level in diabetic and non-diabetic patients.}},
url = {{http://dx.doi.org/10.1111/j.1464-5491.2009.02823.x}},
doi = {{10.1111/j.1464-5491.2009.02823.x}},
volume = {{26}},
year = {{2009}},
}