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Extended-spectrum beta-lactamase-producing Escherichia coli in patients with travellers' diarrhoea.

Tham, Johan LU ; Odenholt, Inga LU ; Walder, Mats LU ; Brolund, Alma; Ahl, Jonas LU and Melander, Eva LU (2010) In Scandinavian Journal of Infectious Diseases 42. p.275-280
Abstract
Abstract The identification of patients carrying extended-spectrum beta-lactamase (ESBL)-producing bacteria is important, since these patients are at risk of receiving inappropriate empirical therapy if they become infected. The purpose of this study was to investigate the occurrence of ESBL-producing bacteria in patients with travellers' diarrhoea. Patients with travellers' diarrhoea (N = 242) having delivered stool samples for the diagnosis of Salmonella, Shigella, Yersinia or Campylobacter, were also examined for ESBL-producing Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis. The overall prevalence of faecal carriage of ESBL-producing bacteria was 24% (58/242). Of the patients who had travelled in Europe, 3% (2/63) were... (More)
Abstract The identification of patients carrying extended-spectrum beta-lactamase (ESBL)-producing bacteria is important, since these patients are at risk of receiving inappropriate empirical therapy if they become infected. The purpose of this study was to investigate the occurrence of ESBL-producing bacteria in patients with travellers' diarrhoea. Patients with travellers' diarrhoea (N = 242) having delivered stool samples for the diagnosis of Salmonella, Shigella, Yersinia or Campylobacter, were also examined for ESBL-producing Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis. The overall prevalence of faecal carriage of ESBL-producing bacteria was 24% (58/242). Of the patients who had travelled in Europe, 3% (2/63) were found to be ESBL carriers in comparison to 36% (50/138) of those who had travelled outside Europe. ESBL-producing E. coli was especially common among patients returning from India (11/14), Egypt (19/38; 50%) and Thailand (8/38; 22%). In total, 90% of the genes of the ESBL-positive samples were of CTX-M type. The CTX-M-1 group dominated, followed by the CTX-M-9 group. The repetitive sequence-based PCR fingerprint pattern showed that there was no similarity between the ESBL strains found. Patients who have travelled outside Europe are at high risk of being colonized with ESBL-producing Enterobacteriaceae, and, if infected, are also at risk of receiving inappropriate empirical antibiotic therapy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
42
pages
275 - 280
publisher
Informa Healthcare
external identifiers
  • WOS:000275470500006
  • PMID:20121649
  • Scopus:77949469252
ISSN
1651-1980
DOI
10.3109/00365540903493715
language
English
LU publication?
yes
id
fe6cc9b6-47e2-4c7b-a787-4287d3e78971 (old id 1553094)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20121649?dopt=Abstract
date added to LUP
2010-03-02 16:59:02
date last changed
2016-10-30 04:35:39
@misc{fe6cc9b6-47e2-4c7b-a787-4287d3e78971,
  abstract     = {Abstract The identification of patients carrying extended-spectrum beta-lactamase (ESBL)-producing bacteria is important, since these patients are at risk of receiving inappropriate empirical therapy if they become infected. The purpose of this study was to investigate the occurrence of ESBL-producing bacteria in patients with travellers' diarrhoea. Patients with travellers' diarrhoea (N = 242) having delivered stool samples for the diagnosis of Salmonella, Shigella, Yersinia or Campylobacter, were also examined for ESBL-producing Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis. The overall prevalence of faecal carriage of ESBL-producing bacteria was 24% (58/242). Of the patients who had travelled in Europe, 3% (2/63) were found to be ESBL carriers in comparison to 36% (50/138) of those who had travelled outside Europe. ESBL-producing E. coli was especially common among patients returning from India (11/14), Egypt (19/38; 50%) and Thailand (8/38; 22%). In total, 90% of the genes of the ESBL-positive samples were of CTX-M type. The CTX-M-1 group dominated, followed by the CTX-M-9 group. The repetitive sequence-based PCR fingerprint pattern showed that there was no similarity between the ESBL strains found. Patients who have travelled outside Europe are at high risk of being colonized with ESBL-producing Enterobacteriaceae, and, if infected, are also at risk of receiving inappropriate empirical antibiotic therapy.},
  author       = {Tham, Johan and Odenholt, Inga and Walder, Mats and Brolund, Alma and Ahl, Jonas and Melander, Eva},
  issn         = {1651-1980},
  language     = {eng},
  pages        = {275--280},
  publisher    = {ARRAY(0x9e3ca28)},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {Extended-spectrum beta-lactamase-producing Escherichia coli in patients with travellers' diarrhoea.},
  url          = {http://dx.doi.org/10.3109/00365540903493715},
  volume       = {42},
  year         = {2010},
}