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Polymorphisms in glutathione-related genes affect methylmercury retention.

Custodio, Hipolito LU ; Broberg Palmgren, Karin LU ; Wennberg, Maria; Jansson, Jan-Håkan; Vessby, Bengt; Hallmans, Goran; Stegmayr, Birgitta and Skerfving, Staffan LU (2004) In Archives of Environmental Health 59(11). p.588-595
Abstract
Methylmercury is eliminated from the human body as glutathione (GSH) conjugates. GSH production is mediated by glutamyl-cysteine ligase (GCL) and conjugation by glutathione S-transferases (GST). In this study, the authors tested whether polymorphisms in GCL and GST genes modify methylmercury retention. Erythrocyte mercury concentration (EryHg), plasma polyunsaturated fatty acids (PPUFA), and genotype for GCLC, GCLM, GSTA1, GSTM1, GSTP1, and GSTT1 were determined in 365 individuals. A general linear model was developed for analyzing whether genotype modified the regression of EryHg on PPUFA. The presence of one variant allele for either GCLC-129 or GSTP1-114 was associated with higher EryHg and steeper regression slope. No similar trends... (More)
Methylmercury is eliminated from the human body as glutathione (GSH) conjugates. GSH production is mediated by glutamyl-cysteine ligase (GCL) and conjugation by glutathione S-transferases (GST). In this study, the authors tested whether polymorphisms in GCL and GST genes modify methylmercury retention. Erythrocyte mercury concentration (EryHg), plasma polyunsaturated fatty acids (PPUFA), and genotype for GCLC, GCLM, GSTA1, GSTM1, GSTP1, and GSTT1 were determined in 365 individuals. A general linear model was developed for analyzing whether genotype modified the regression of EryHg on PPUFA. The presence of one variant allele for either GCLC-129 or GSTP1-114 was associated with higher EryHg and steeper regression slope. No similar trends were shown for GCLM, GSTA1, GSTM1, or GSTT1. These findings indicate that GCLC polymorphisms that affect GSH production also affect methylmercury retention, and that GSTP1 may play a role in conjugating methylmercury with GSH. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Archives of Environmental Health
volume
59
issue
11
pages
588 - 595
publisher
Heldref Publications
external identifiers
  • WOS:000236334700008
  • PMID:16599007
  • Scopus:33645472292
ISSN
0003-9896
language
English
LU publication?
yes
id
2310ebe8-5ab1-42f7-9b61-a6bc02794558 (old id 156024)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16599007&dopt=Abstract
date added to LUP
2007-06-25 08:02:03
date last changed
2016-10-30 04:37:12
@misc{2310ebe8-5ab1-42f7-9b61-a6bc02794558,
  abstract     = {Methylmercury is eliminated from the human body as glutathione (GSH) conjugates. GSH production is mediated by glutamyl-cysteine ligase (GCL) and conjugation by glutathione S-transferases (GST). In this study, the authors tested whether polymorphisms in GCL and GST genes modify methylmercury retention. Erythrocyte mercury concentration (EryHg), plasma polyunsaturated fatty acids (PPUFA), and genotype for GCLC, GCLM, GSTA1, GSTM1, GSTP1, and GSTT1 were determined in 365 individuals. A general linear model was developed for analyzing whether genotype modified the regression of EryHg on PPUFA. The presence of one variant allele for either GCLC-129 or GSTP1-114 was associated with higher EryHg and steeper regression slope. No similar trends were shown for GCLM, GSTA1, GSTM1, or GSTT1. These findings indicate that GCLC polymorphisms that affect GSH production also affect methylmercury retention, and that GSTP1 may play a role in conjugating methylmercury with GSH.},
  author       = {Custodio, Hipolito and Broberg Palmgren, Karin and Wennberg, Maria and Jansson, Jan-Håkan and Vessby, Bengt and Hallmans, Goran and Stegmayr, Birgitta and Skerfving, Staffan},
  issn         = {0003-9896},
  language     = {eng},
  number       = {11},
  pages        = {588--595},
  publisher    = {ARRAY(0xcbd5818)},
  series       = {Archives of Environmental Health},
  title        = {Polymorphisms in glutathione-related genes affect methylmercury retention.},
  volume       = {59},
  year         = {2004},
}