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Variation in the PTH Gene, Hip Fracture, and Femoral Neck Geometry in Elderly Women.

Tenne, Max LU ; McGuigan, Fiona LU ; Ahlborg, Henrik LU ; Gerdhem, Paul LU and Åkesson, Kristina LU (2010) In Calcified Tissue International 86(5). p.359-366
Abstract
Parathyroid hormone (PTH) is a principal regulator of calcium homeostasis. Previously, we studied single-nucleotide polymorphisms present in the major genes in the PTH pathway (PTH, PTHrP, PTHR1, PTHR2) in relation to bone mineral density (BMD) and fracture incidence. We found that haplotypes of the PTH gene were associated with fracture risk independent of BMD. In the present study, we evaluated the relationship between PTH haplotypes and femoral neck bone size. Hip structure analysis and BMD of the femoral neck was assessed by DXA in elderly women from the Malmö Osteoporosis Prospective Risk Assessment study. Data on hip fracture, sustained as a result of low trauma, after the age of 45 years were also analyzed. Haplotypes derived from... (More)
Parathyroid hormone (PTH) is a principal regulator of calcium homeostasis. Previously, we studied single-nucleotide polymorphisms present in the major genes in the PTH pathway (PTH, PTHrP, PTHR1, PTHR2) in relation to bone mineral density (BMD) and fracture incidence. We found that haplotypes of the PTH gene were associated with fracture risk independent of BMD. In the present study, we evaluated the relationship between PTH haplotypes and femoral neck bone size. Hip structure analysis and BMD of the femoral neck was assessed by DXA in elderly women from the Malmö Osteoporosis Prospective Risk Assessment study. Data on hip fracture, sustained as a result of low trauma, after the age of 45 years were also analyzed. Haplotypes derived from six polymorphisms in the PTH locus were analyzed in 750 women. Carriers of haplotype 9 had lower values for hip geometry parameters cross-sectional moment of inertia (P = 0.029), femoral neck width (P = 0.049), and section modulous (P = 0.06), suggestive of increased fracture risk at the hip. However, this did not translate into an increased incidence of hip fracture in the studied population. Women who suffered a hip fracture compared to those who had not had longer hip axis length (HAL) (P < 0.001). HAL was not significantly different among haplotypes. Polymorphisms in the PTH gene are associated with differences in aspects of femoral neck geometry in elderly women; however, the major predictor of hip fracture in our population was HAL, to which PTH gene variation does not contribute significantly. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Calcified Tissue International
volume
86
issue
5
pages
359 - 366
publisher
Springer
external identifiers
  • WOS:000277014000004
  • PMID:20349051
  • Scopus:77953363476
ISSN
1432-0827
DOI
10.1007/s00223-010-9351-6
language
English
LU publication?
yes
id
7985254f-1d3c-4ce8-8531-27d10182757e (old id 1581469)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20349051?dopt=Abstract
date added to LUP
2010-04-07 12:17:57
date last changed
2016-10-13 04:32:00
@misc{7985254f-1d3c-4ce8-8531-27d10182757e,
  abstract     = {Parathyroid hormone (PTH) is a principal regulator of calcium homeostasis. Previously, we studied single-nucleotide polymorphisms present in the major genes in the PTH pathway (PTH, PTHrP, PTHR1, PTHR2) in relation to bone mineral density (BMD) and fracture incidence. We found that haplotypes of the PTH gene were associated with fracture risk independent of BMD. In the present study, we evaluated the relationship between PTH haplotypes and femoral neck bone size. Hip structure analysis and BMD of the femoral neck was assessed by DXA in elderly women from the Malmö Osteoporosis Prospective Risk Assessment study. Data on hip fracture, sustained as a result of low trauma, after the age of 45 years were also analyzed. Haplotypes derived from six polymorphisms in the PTH locus were analyzed in 750 women. Carriers of haplotype 9 had lower values for hip geometry parameters cross-sectional moment of inertia (P = 0.029), femoral neck width (P = 0.049), and section modulous (P = 0.06), suggestive of increased fracture risk at the hip. However, this did not translate into an increased incidence of hip fracture in the studied population. Women who suffered a hip fracture compared to those who had not had longer hip axis length (HAL) (P &lt; 0.001). HAL was not significantly different among haplotypes. Polymorphisms in the PTH gene are associated with differences in aspects of femoral neck geometry in elderly women; however, the major predictor of hip fracture in our population was HAL, to which PTH gene variation does not contribute significantly.},
  author       = {Tenne, Max and McGuigan, Fiona and Ahlborg, Henrik and Gerdhem, Paul and Åkesson, Kristina},
  issn         = {1432-0827},
  language     = {eng},
  number       = {5},
  pages        = {359--366},
  publisher    = {ARRAY(0x9377550)},
  series       = {Calcified Tissue International},
  title        = {Variation in the PTH Gene, Hip Fracture, and Femoral Neck Geometry in Elderly Women.},
  url          = {http://dx.doi.org/10.1007/s00223-010-9351-6},
  volume       = {86},
  year         = {2010},
}