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ZnT8 autoantibody titers in type 1 diabetes patients decline rapidly after clinical onset.

Vaziri Sani, Fariba LU ; Oak, Shilpa; Radtke, Jared; Lernmark, Åke LU ; Lynch, Kristian LU ; Agardh, Carl-David LU ; Cilio, Corrado LU ; Lethagen, ÅsaLinda LU ; Ortqvist, Eva and Landin-Olsson, Mona LU , et al. (2010) In Autoimmunity Apr 7. p.598-606
Abstract
Autoantibodies to the islet-specific zinc transporter isoform 8 (ZnT8) are detected in the majority of type 1 diabetes patients prior to and at clinical diagnosis. The presence of ZnT8Ab after diagnosis has not been investigated. This study analyzed the autoantibody response to ZnT8 in regard to age at onset and disease duration. Two new onset type 1 diabetes patient cohorts with different age distributions at onset (2-17 and 15-34 years of age at onset), a longitudinal subset of the younger type 1 diabetes patient cohort (n = 32), and a cohort of GAD65Ab-positive LADA patients (n = 47) was analyzed for the presence of autoantibodies directed to the two major isoforms, ZnT8-Arginine (ZnT8R) and ZnT8-Tryptophan (ZnT8W). The majority of type... (More)
Autoantibodies to the islet-specific zinc transporter isoform 8 (ZnT8) are detected in the majority of type 1 diabetes patients prior to and at clinical diagnosis. The presence of ZnT8Ab after diagnosis has not been investigated. This study analyzed the autoantibody response to ZnT8 in regard to age at onset and disease duration. Two new onset type 1 diabetes patient cohorts with different age distributions at onset (2-17 and 15-34 years of age at onset), a longitudinal subset of the younger type 1 diabetes patient cohort (n = 32), and a cohort of GAD65Ab-positive LADA patients (n = 47) was analyzed for the presence of autoantibodies directed to the two major isoforms, ZnT8-Arginine (ZnT8R) and ZnT8-Tryptophan (ZnT8W). The majority of type 1 diabetes patients tested positive for ZnT8Ab to both isoforms. ZnT8Ab titers were significantly higher in the younger type 1 diabetes patients as compared with the older cohort (ZnT8RAb at a median of 148 and 29 U/ml, respectively, p < 0.001) (ZnT8WAb at a median of 145 and 58 U/ml, respectively, p < 0.01). ZnT8RAb and ZnT8WAb titers were significantly lower in the LADA patients (ZnT8RAb at a median of 14 U/ml, ZnT8WAb at a median of 25 U/ml) as compared with either type 1 diabetes cohorts. In our longitudinal analysis of type 1 diabetes patients after clinical diagnosis, ZnT8Ab levels to both isoforms declined significantly during the initial year of disease (ZnT8RAb from a median of 320-162 U/ml, p = 0.0001; ZnT8WAb from a median of 128-46 U/ml, p = 0.0011). The antibody titers further declined during the following 4 years (p < 0.0001). We conclude that ZnT8Ab presents a useful marker for type 1 diabetes, especially in younger patients at disease diagnosis. (Less)
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published
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Autoimmunity
volume
Apr 7
pages
598 - 606
publisher
Taylor & Francis
external identifiers
  • WOS:000284074300004
  • PMID:20298127
  • Scopus:78149462294
ISSN
0891-6934
DOI
10.3109/08916930903555927
language
English
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yes
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7e5f3691-0cf4-489e-abd4-86d6066ee3c3 (old id 1581905)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20298127?dopt=Abstract
date added to LUP
2010-04-07 22:06:15
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2016-11-13 04:29:02
@misc{7e5f3691-0cf4-489e-abd4-86d6066ee3c3,
  abstract     = {Autoantibodies to the islet-specific zinc transporter isoform 8 (ZnT8) are detected in the majority of type 1 diabetes patients prior to and at clinical diagnosis. The presence of ZnT8Ab after diagnosis has not been investigated. This study analyzed the autoantibody response to ZnT8 in regard to age at onset and disease duration. Two new onset type 1 diabetes patient cohorts with different age distributions at onset (2-17 and 15-34 years of age at onset), a longitudinal subset of the younger type 1 diabetes patient cohort (n = 32), and a cohort of GAD65Ab-positive LADA patients (n = 47) was analyzed for the presence of autoantibodies directed to the two major isoforms, ZnT8-Arginine (ZnT8R) and ZnT8-Tryptophan (ZnT8W). The majority of type 1 diabetes patients tested positive for ZnT8Ab to both isoforms. ZnT8Ab titers were significantly higher in the younger type 1 diabetes patients as compared with the older cohort (ZnT8RAb at a median of 148 and 29 U/ml, respectively, p &lt; 0.001) (ZnT8WAb at a median of 145 and 58 U/ml, respectively, p &lt; 0.01). ZnT8RAb and ZnT8WAb titers were significantly lower in the LADA patients (ZnT8RAb at a median of 14 U/ml, ZnT8WAb at a median of 25 U/ml) as compared with either type 1 diabetes cohorts. In our longitudinal analysis of type 1 diabetes patients after clinical diagnosis, ZnT8Ab levels to both isoforms declined significantly during the initial year of disease (ZnT8RAb from a median of 320-162 U/ml, p = 0.0001; ZnT8WAb from a median of 128-46 U/ml, p = 0.0011). The antibody titers further declined during the following 4 years (p &lt; 0.0001). We conclude that ZnT8Ab presents a useful marker for type 1 diabetes, especially in younger patients at disease diagnosis.},
  author       = {Vaziri Sani, Fariba and Oak, Shilpa and Radtke, Jared and Lernmark, Åke and Lynch, Kristian and Agardh, Carl-David and Cilio, Corrado and Lethagen, ÅsaLinda and Ortqvist, Eva and Landin-Olsson, Mona and Törn, Carina and Hampe, Christiane S},
  issn         = {0891-6934},
  language     = {eng},
  pages        = {598--606},
  publisher    = {ARRAY(0x9b4db60)},
  series       = {Autoimmunity},
  title        = {ZnT8 autoantibody titers in type 1 diabetes patients decline rapidly after clinical onset.},
  url          = {http://dx.doi.org/10.3109/08916930903555927},
  volume       = {Apr 7},
  year         = {2010},
}