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Evidence for Geographical and Racial Variation in Serum Sex Steroid Levels in Older Men.

Orwoll, Eric S; Nielson, Carrie M; Labrie, Fernand; Barrett-Connor, Elizabeth; Cauley, Jane A; Cummings, Steven R; Ensrud, Kristine; Karlsson, Magnus LU ; Lau, Edith and Leung, P C, et al. (2010) In The Journal of clinical endocrinology and metabolism 95. p.151-160
Abstract
Background: Despite considerable racial and geographical differences in human phenotypes and in the incidence of diseases that may be associated with sex steroid action, there are few data concerning variation in sex steroid levels among populations. We designed an international study to determine the degree to which geography and race influence sex steroid levels in older men. Methods: Using mass spectrometry, concentrations of serum androgens, estrogens, and sex steroid precursors/metabolites were measured in 5003 older men from five countries. SHBG levels were assessed using radioimmunoassay. Results: There was substantial geographical variation in the levels of sex steroids, precursors, and metabolites, as well as SHBG. For instance,... (More)
Background: Despite considerable racial and geographical differences in human phenotypes and in the incidence of diseases that may be associated with sex steroid action, there are few data concerning variation in sex steroid levels among populations. We designed an international study to determine the degree to which geography and race influence sex steroid levels in older men. Methods: Using mass spectrometry, concentrations of serum androgens, estrogens, and sex steroid precursors/metabolites were measured in 5003 older men from five countries. SHBG levels were assessed using radioimmunoassay. Results: There was substantial geographical variation in the levels of sex steroids, precursors, and metabolites, as well as SHBG. For instance, Asian men in Hong Kong and Japan, but not in the United States, had levels of total testosterone approximately 20% higher than in other groups. Even greater variation was present in levels of estradiol, SHBG, and dihydrotestosterone. Group differences in body mass index did not explain most geographical differences. In addition, body mass index-independent racial differences were present; Black men had higher levels of estrogens (estradiol, estrone), and Asian men had lower levels of glucuronidated androgen metabolites. Conclusions: On a global scale, there are important geographical and racial differences in the concentrations of serum sex steroids and SHBG in older men. (Less)
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publication status
published
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in
The Journal of clinical endocrinology and metabolism
volume
95
pages
151 - 160
publisher
The Endocrine Society
external identifiers
  • WOS:000282573300041
  • PMID:20668046
  • Scopus:77957785833
ISSN
1945-7197
DOI
10.1210/jc.2009-2435
language
English
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yes
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24ae1bac-3708-42e9-a818-c1c60a8a0d04 (old id 1644459)
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http://www.ncbi.nlm.nih.gov/pubmed/20668046?dopt=Abstract
date added to LUP
2010-08-05 10:46:43
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2016-11-09 14:39:56
@misc{24ae1bac-3708-42e9-a818-c1c60a8a0d04,
  abstract     = {Background: Despite considerable racial and geographical differences in human phenotypes and in the incidence of diseases that may be associated with sex steroid action, there are few data concerning variation in sex steroid levels among populations. We designed an international study to determine the degree to which geography and race influence sex steroid levels in older men. Methods: Using mass spectrometry, concentrations of serum androgens, estrogens, and sex steroid precursors/metabolites were measured in 5003 older men from five countries. SHBG levels were assessed using radioimmunoassay. Results: There was substantial geographical variation in the levels of sex steroids, precursors, and metabolites, as well as SHBG. For instance, Asian men in Hong Kong and Japan, but not in the United States, had levels of total testosterone approximately 20% higher than in other groups. Even greater variation was present in levels of estradiol, SHBG, and dihydrotestosterone. Group differences in body mass index did not explain most geographical differences. In addition, body mass index-independent racial differences were present; Black men had higher levels of estrogens (estradiol, estrone), and Asian men had lower levels of glucuronidated androgen metabolites. Conclusions: On a global scale, there are important geographical and racial differences in the concentrations of serum sex steroids and SHBG in older men.},
  author       = {Orwoll, Eric S and Nielson, Carrie M and Labrie, Fernand and Barrett-Connor, Elizabeth and Cauley, Jane A and Cummings, Steven R and Ensrud, Kristine and Karlsson, Magnus and Lau, Edith and Leung, P C and Lunggren, Osten and Mellström, Dan and Patrick, Alan L and Stefanick, Marcia L and Nakamura, Kozo and Yoshimura, Noriko and Zmuda, Joseph and Vandenput, Liesbeth and Ohlsson, Claes},
  issn         = {1945-7197},
  language     = {eng},
  pages        = {151--160},
  publisher    = {ARRAY(0x86b4d40)},
  series       = {The Journal of clinical endocrinology and metabolism},
  title        = {Evidence for Geographical and Racial Variation in Serum Sex Steroid Levels in Older Men.},
  url          = {http://dx.doi.org/10.1210/jc.2009-2435},
  volume       = {95},
  year         = {2010},
}