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Cancer Risk in Children and Young Adults Conceived by In Vitro Fertilization.

Källén, Bengt LU ; Finnström, Orvar; Lindam, Anna; Nilsson, Emma LU ; Nygren, Karl-Gösta and Olausson, Petra Otterblad (2010) In Pediatrics 126. p.270-276
Abstract
Objectives: Studies conducted so far have found no statistically significant increased risk for cancer among children who are born after in vitro fertilization (IVF). Methods: We followed 26692 children who were born after IVF during the years 1982-2005 by using the Swedish Cancer Register and compared the number of children who had cancer and were born after IVF with children who were not conceived by IVF. Adjustment was made for year of birth. Results: Maternal age, parity, smoking, subfertility, previous miscarriages, BMI, and multiple births did not significantly affect cancer risk in offspring. High birth weight, premature delivery, and the presence of respiratory diagnoses and low Apgar score were risk factors for cancer. We... (More)
Objectives: Studies conducted so far have found no statistically significant increased risk for cancer among children who are born after in vitro fertilization (IVF). Methods: We followed 26692 children who were born after IVF during the years 1982-2005 by using the Swedish Cancer Register and compared the number of children who had cancer and were born after IVF with children who were not conceived by IVF. Adjustment was made for year of birth. Results: Maternal age, parity, smoking, subfertility, previous miscarriages, BMI, and multiple births did not significantly affect cancer risk in offspring. High birth weight, premature delivery, and the presence of respiratory diagnoses and low Apgar score were risk factors for cancer. We identified 53 cases of cancer in children who were born after IVF against 38 expected cases: 18 of them with hematologic cancer (15 of them acute lymphoblastic leukemia), 17 with eye or central nervous system tumors, and 12 with other solid cancers. There were 6 cases of Langerhans histiocytosis against 1.0 expected. The total cancer risk estimate was 1.42 (95% confidence interval: 1.09-1.87). Conclusions: We found a moderately increased risk for cancer in children who were conceived by IVF. Putative intermediary factors could be preterm birth and neonatal asphyxia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatrics
volume
126
pages
270 - 276
publisher
American Academy of Pediatrics
external identifiers
  • WOS:000280565700012
  • PMID:20643723
  • Scopus:77955483324
ISSN
1098-4275
DOI
10.1542/peds.2009-3225
language
English
LU publication?
yes
id
dac6a000-4c88-4757-8bac-029f9aac1ae0 (old id 1644766)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20643723?dopt=Abstract
date added to LUP
2010-08-05 09:25:31
date last changed
2016-11-27 04:30:13
@misc{dac6a000-4c88-4757-8bac-029f9aac1ae0,
  abstract     = {Objectives: Studies conducted so far have found no statistically significant increased risk for cancer among children who are born after in vitro fertilization (IVF). Methods: We followed 26692 children who were born after IVF during the years 1982-2005 by using the Swedish Cancer Register and compared the number of children who had cancer and were born after IVF with children who were not conceived by IVF. Adjustment was made for year of birth. Results: Maternal age, parity, smoking, subfertility, previous miscarriages, BMI, and multiple births did not significantly affect cancer risk in offspring. High birth weight, premature delivery, and the presence of respiratory diagnoses and low Apgar score were risk factors for cancer. We identified 53 cases of cancer in children who were born after IVF against 38 expected cases: 18 of them with hematologic cancer (15 of them acute lymphoblastic leukemia), 17 with eye or central nervous system tumors, and 12 with other solid cancers. There were 6 cases of Langerhans histiocytosis against 1.0 expected. The total cancer risk estimate was 1.42 (95% confidence interval: 1.09-1.87). Conclusions: We found a moderately increased risk for cancer in children who were conceived by IVF. Putative intermediary factors could be preterm birth and neonatal asphyxia.},
  author       = {Källén, Bengt and Finnström, Orvar and Lindam, Anna and Nilsson, Emma and Nygren, Karl-Gösta and Olausson, Petra Otterblad},
  issn         = {1098-4275},
  language     = {eng},
  pages        = {270--276},
  publisher    = {ARRAY(0xa8c0db0)},
  series       = {Pediatrics},
  title        = {Cancer Risk in Children and Young Adults Conceived by In Vitro Fertilization.},
  url          = {http://dx.doi.org/10.1542/peds.2009-3225},
  volume       = {126},
  year         = {2010},
}