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Differential Glucose-Regulation of MicroRNAs in Pancreatic Islets of Non-Obese Type 2 Diabetes Model Goto-Kakizaki Rat.

Esguerra, Jonathan LU ; Bolmeson, Caroline LU ; Cilio, Corrado LU and Eliasson, Lena LU (2011) In PLoS One 6(4).
Abstract
The Goto-Kakizaki (GK) rat is a well-studied non-obese spontaneous type 2 diabetes (T2D) animal model characterized by impaired glucose-stimulated insulin secretion (GSIS) in the pancreatic beta cells. MicroRNAs (miRNAs) are short regulatory RNAs involved in many fundamental biological processes. We aim to identify miRNAs that are differentially-expressed in the pancreatic islets of the GK rats and investigate both their short- and long term glucose-dependence during glucose-stimulatory conditions.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Islets of Langerhans/*drug effects/*metabolism, MicroRNAs/*genetics, Glucose/*pharmacology, Gene Expression Profiling, Animals, Type 2/*metabolism, Diabetes Mellitus, Polymerase Chain Reaction, Rats, Wistar
in
PLoS One
volume
6
issue
4
publisher
Public Library of Science
external identifiers
  • WOS:000289238700029
  • PMID:21490936
  • Scopus:79954555856
ISSN
1932-6203
DOI
10.1371/journal.pone.0018613
language
English
LU publication?
yes
id
a3eed891-e89f-4675-915e-30b5cb5db6f2 (old id 1937116)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21490936?dopt=Abstract
date added to LUP
2011-05-02 14:15:13
date last changed
2016-11-20 04:24:11
@misc{a3eed891-e89f-4675-915e-30b5cb5db6f2,
  abstract     = {The Goto-Kakizaki (GK) rat is a well-studied non-obese spontaneous type 2 diabetes (T2D) animal model characterized by impaired glucose-stimulated insulin secretion (GSIS) in the pancreatic beta cells. MicroRNAs (miRNAs) are short regulatory RNAs involved in many fundamental biological processes. We aim to identify miRNAs that are differentially-expressed in the pancreatic islets of the GK rats and investigate both their short- and long term glucose-dependence during glucose-stimulatory conditions.},
  author       = {Esguerra, Jonathan and Bolmeson, Caroline and Cilio, Corrado and Eliasson, Lena},
  issn         = {1932-6203},
  keyword      = {Islets of Langerhans/*drug effects/*metabolism,MicroRNAs/*genetics,Glucose/*pharmacology,Gene Expression Profiling,Animals,Type 2/*metabolism,Diabetes Mellitus,Polymerase Chain Reaction,Rats,Wistar},
  language     = {eng},
  number       = {4},
  publisher    = {ARRAY(0x8544308)},
  series       = {PLoS One},
  title        = {Differential Glucose-Regulation of MicroRNAs in Pancreatic Islets of Non-Obese Type 2 Diabetes Model Goto-Kakizaki Rat.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0018613},
  volume       = {6},
  year         = {2011},
}