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Differential Glucose-Regulation of MicroRNAs in Pancreatic Islets of Non-Obese Type 2 Diabetes Model Goto-Kakizaki Rat.

Esguerra, Jonathan LU orcid ; Bolmeson, Caroline LU ; Cilio, Corrado LU and Eliasson, Lena LU orcid (2011) In PLoS ONE 6(4).
Abstract
The Goto-Kakizaki (GK) rat is a well-studied non-obese spontaneous type 2 diabetes (T2D) animal model characterized by impaired glucose-stimulated insulin secretion (GSIS) in the pancreatic beta cells. MicroRNAs (miRNAs) are short regulatory RNAs involved in many fundamental biological processes. We aim to identify miRNAs that are differentially-expressed in the pancreatic islets of the GK rats and investigate both their short- and long term glucose-dependence during glucose-stimulatory conditions.
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Islets of Langerhans/*drug effects/*metabolism, MicroRNAs/*genetics, Glucose/*pharmacology, Gene Expression Profiling, Animals, Type 2/*metabolism, Diabetes Mellitus, Polymerase Chain Reaction, Rats, Wistar
in
PLoS ONE
volume
6
issue
4
article number
e18613
publisher
Public Library of Science (PLoS)
external identifiers
  • wos:000289238700029
  • pmid:21490936
  • scopus:79954555856
ISSN
1932-6203
DOI
10.1371/journal.pone.0018613
language
English
LU publication?
yes
id
a3eed891-e89f-4675-915e-30b5cb5db6f2 (old id 1937116)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21490936?dopt=Abstract
date added to LUP
2016-04-04 09:37:46
date last changed
2022-04-08 03:52:24
@article{a3eed891-e89f-4675-915e-30b5cb5db6f2,
  abstract     = {{The Goto-Kakizaki (GK) rat is a well-studied non-obese spontaneous type 2 diabetes (T2D) animal model characterized by impaired glucose-stimulated insulin secretion (GSIS) in the pancreatic beta cells. MicroRNAs (miRNAs) are short regulatory RNAs involved in many fundamental biological processes. We aim to identify miRNAs that are differentially-expressed in the pancreatic islets of the GK rats and investigate both their short- and long term glucose-dependence during glucose-stimulatory conditions.}},
  author       = {{Esguerra, Jonathan and Bolmeson, Caroline and Cilio, Corrado and Eliasson, Lena}},
  issn         = {{1932-6203}},
  keywords     = {{Islets of Langerhans/*drug effects/*metabolism; MicroRNAs/*genetics; Glucose/*pharmacology; Gene Expression Profiling; Animals; Type 2/*metabolism; Diabetes Mellitus; Polymerase Chain Reaction; Rats; Wistar}},
  language     = {{eng}},
  number       = {{4}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS ONE}},
  title        = {{Differential Glucose-Regulation of MicroRNAs in Pancreatic Islets of Non-Obese Type 2 Diabetes Model Goto-Kakizaki Rat.}},
  url          = {{https://lup.lub.lu.se/search/files/5375095/1961773.pdf}},
  doi          = {{10.1371/journal.pone.0018613}},
  volume       = {{6}},
  year         = {{2011}},
}