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Age and gender differences in the association between Nt-proBNP and glucometabolic disturbances.

Leosdottir, Margrét LU ; Willenheimer, Ronnie LU ; Hall, Christian; Tjora, Solve; Malm, Johan LU ; Melander, Olle LU and Nilsson, Peter LU (2011) In Scandinavian cardiovascular journal : SCJ 45. p.294-300
Abstract
Abstract Objectives. Glucometabolic disturbances are associated with myocardial dysfunction. Brain natriuretic peptides (BNP) are used for detecting myocardial dysfunction in clinical practice. However, studies on elderly subjects and gender-specific analyses are sparse. Design. We examined cross-sectional associations between Nt-proBNP and 1) fasting plasma glucose (FPG), and 2) categories of glucometabolic disturbances, in middle-aged and older subjects (1266 men, 526 women), applying multivariate linear regression analysis. Results. FPG was positively correlated with Nt-proBNP among middle-aged men (p = 0.04) and negatively albeit non-significantly (p = 0.1) among middle-aged women. Weaker non-significant correlations were seen among... (More)
Abstract Objectives. Glucometabolic disturbances are associated with myocardial dysfunction. Brain natriuretic peptides (BNP) are used for detecting myocardial dysfunction in clinical practice. However, studies on elderly subjects and gender-specific analyses are sparse. Design. We examined cross-sectional associations between Nt-proBNP and 1) fasting plasma glucose (FPG), and 2) categories of glucometabolic disturbances, in middle-aged and older subjects (1266 men, 526 women), applying multivariate linear regression analysis. Results. FPG was positively correlated with Nt-proBNP among middle-aged men (p = 0.04) and negatively albeit non-significantly (p = 0.1) among middle-aged women. Weaker non-significant correlations were seen among older subjects. Middle-aged men with new-onset and prevalent diabetes had higher Nt-proBNP than the reference group (FPG ≤5.0 mmol/L): 9.53 (p = 0.002) and 8.23 (p = 0.02) vs. 5.71 pmol/L. No differences in Nt-proBNP between categories of glucometabolic disturbance were observed among older men or women. Conclusions. The results indicate an age- and gender difference in the ability of Nt-proBNP to identify myocardial dysfunction in relation to glucometabolic disturbances. Therefore, Nt-proBNP should be used with caution as a general surrogate marker for myocardial dysfunction in this setting. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian cardiovascular journal : SCJ
volume
45
pages
294 - 300
publisher
Taylor & Francis
external identifiers
  • WOS:000296431100007
  • PMID:21604967
  • Scopus:80455131144
ISSN
1651-2006
DOI
10.3109/14017431.2011.581763
language
English
LU publication?
yes
id
e1c7fd15-a8a3-45d4-991c-4ace263e2bf1 (old id 1972230)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21604967?dopt=Abstract
date added to LUP
2011-06-07 22:08:24
date last changed
2016-11-08 14:10:28
@misc{e1c7fd15-a8a3-45d4-991c-4ace263e2bf1,
  abstract     = {Abstract Objectives. Glucometabolic disturbances are associated with myocardial dysfunction. Brain natriuretic peptides (BNP) are used for detecting myocardial dysfunction in clinical practice. However, studies on elderly subjects and gender-specific analyses are sparse. Design. We examined cross-sectional associations between Nt-proBNP and 1) fasting plasma glucose (FPG), and 2) categories of glucometabolic disturbances, in middle-aged and older subjects (1266 men, 526 women), applying multivariate linear regression analysis. Results. FPG was positively correlated with Nt-proBNP among middle-aged men (p = 0.04) and negatively albeit non-significantly (p = 0.1) among middle-aged women. Weaker non-significant correlations were seen among older subjects. Middle-aged men with new-onset and prevalent diabetes had higher Nt-proBNP than the reference group (FPG ≤5.0 mmol/L): 9.53 (p = 0.002) and 8.23 (p = 0.02) vs. 5.71 pmol/L. No differences in Nt-proBNP between categories of glucometabolic disturbance were observed among older men or women. Conclusions. The results indicate an age- and gender difference in the ability of Nt-proBNP to identify myocardial dysfunction in relation to glucometabolic disturbances. Therefore, Nt-proBNP should be used with caution as a general surrogate marker for myocardial dysfunction in this setting.},
  author       = {Leosdottir, Margrét and Willenheimer, Ronnie and Hall, Christian and Tjora, Solve and Malm, Johan and Melander, Olle and Nilsson, Peter},
  issn         = {1651-2006},
  language     = {eng},
  pages        = {294--300},
  publisher    = {ARRAY(0x93acba0)},
  series       = {Scandinavian cardiovascular journal : SCJ},
  title        = {Age and gender differences in the association between Nt-proBNP and glucometabolic disturbances.},
  url          = {http://dx.doi.org/10.3109/14017431.2011.581763},
  volume       = {45},
  year         = {2011},
}