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The Relationships between Sex Hormones and Sexual Function in Middle-Aged and Older European Men.

O'Connor, Daryl B; Lee, David M; Corona, Giovanni; Forti, Gianni; Tajar, Abdelouahid; O'Neill, Terence W; Pendleton, Neil; Bartfai, Gyorgy; Boonen, Steven and Casanueva, Felipe F, et al. (2011) In The Journal of clinical endocrinology and metabolism 96. p.1577-1587
Abstract
Context: Limited data are available exploring the associations between sex hormones, multiple domains of sexual functioning, and sexual function-related distress in nonpatient samples in Europe. Objectives: The aim of the study was to investigate the relationships between serum testosterone (T), estradiol (E2), and dihydrotestosterone (DHT) and sexual function in a multicenter population-based study of aging in men. Design: Using stratified random sampling, 2838 men aged 40-79 yr completed the European Male Ageing Study-Sexual Function Questionnaire and provided a blood sample for hormone measurements. T, E2, and DHT were measured using gas chromatography-mass spectrometry. Setting: We conducted a community-based population survey in eight... (More)
Context: Limited data are available exploring the associations between sex hormones, multiple domains of sexual functioning, and sexual function-related distress in nonpatient samples in Europe. Objectives: The aim of the study was to investigate the relationships between serum testosterone (T), estradiol (E2), and dihydrotestosterone (DHT) and sexual function in a multicenter population-based study of aging in men. Design: Using stratified random sampling, 2838 men aged 40-79 yr completed the European Male Ageing Study-Sexual Function Questionnaire and provided a blood sample for hormone measurements. T, E2, and DHT were measured using gas chromatography-mass spectrometry. Setting: We conducted a community-based population survey in eight European centers. Main Outcome Measures: Self-reported sexual function (overall sexual function, sexual function-related distress, erectile dysfunction, masturbation) was measured. Results: Total and free T, but not E2 or DHT, was associated with overall sexual function in middle-aged and older men. E2 was the only hormone associated with sexual function-related distress such that higher levels were related to greater distress. Free T levels were associated with masturbation frequency and erectile dysfunction in the fully adjusted models, such that higher T was associated with less dysfunction and greater frequency. Moreover, there was a T threshold for the relationship between total T, sexual function, and erectile dysfunction. At T concentrations of 8 nmol/liter or less, T was associated with worse sexual functioning, whereas at T levels over 8 nmol/liter, the relationship came to a plateau. Conclusions: These findings suggest that different hormonal mechanisms may regulate sexual functioning (T) vs. the psychological aspects (E2) of male sexual behavior. Moreover, there was a T threshold for overall sexual function such that at levels greater than 8 nmol/liter the relationship between T and sexual function did not become stronger. (Less)
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The Journal of clinical endocrinology and metabolism
volume
96
pages
1577 - 1587
publisher
The Endocrine Society
external identifiers
  • WOS:000295879600003
  • PMID:21849522
  • Scopus:80053534245
ISSN
1945-7197
DOI
10.1210/jc.2010-2216
language
English
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yes
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d436dc6e-dbdc-44a4-8364-efdedd1b4dce (old id 2150921)
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http://www.ncbi.nlm.nih.gov/pubmed/21849522?dopt=Abstract
date added to LUP
2011-09-04 22:24:04
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2016-11-09 14:39:55
@misc{d436dc6e-dbdc-44a4-8364-efdedd1b4dce,
  abstract     = {Context: Limited data are available exploring the associations between sex hormones, multiple domains of sexual functioning, and sexual function-related distress in nonpatient samples in Europe. Objectives: The aim of the study was to investigate the relationships between serum testosterone (T), estradiol (E2), and dihydrotestosterone (DHT) and sexual function in a multicenter population-based study of aging in men. Design: Using stratified random sampling, 2838 men aged 40-79 yr completed the European Male Ageing Study-Sexual Function Questionnaire and provided a blood sample for hormone measurements. T, E2, and DHT were measured using gas chromatography-mass spectrometry. Setting: We conducted a community-based population survey in eight European centers. Main Outcome Measures: Self-reported sexual function (overall sexual function, sexual function-related distress, erectile dysfunction, masturbation) was measured. Results: Total and free T, but not E2 or DHT, was associated with overall sexual function in middle-aged and older men. E2 was the only hormone associated with sexual function-related distress such that higher levels were related to greater distress. Free T levels were associated with masturbation frequency and erectile dysfunction in the fully adjusted models, such that higher T was associated with less dysfunction and greater frequency. Moreover, there was a T threshold for the relationship between total T, sexual function, and erectile dysfunction. At T concentrations of 8 nmol/liter or less, T was associated with worse sexual functioning, whereas at T levels over 8 nmol/liter, the relationship came to a plateau. Conclusions: These findings suggest that different hormonal mechanisms may regulate sexual functioning (T) vs. the psychological aspects (E2) of male sexual behavior. Moreover, there was a T threshold for overall sexual function such that at levels greater than 8 nmol/liter the relationship between T and sexual function did not become stronger.},
  author       = {O'Connor, Daryl B and Lee, David M and Corona, Giovanni and Forti, Gianni and Tajar, Abdelouahid and O'Neill, Terence W and Pendleton, Neil and Bartfai, Gyorgy and Boonen, Steven and Casanueva, Felipe F and Finn, Joseph D and Giwercman, Aleksander and Han, Thang S and Huhtaniemi, Ilpo T and Kula, Krzysztof and Labrie, Fernand and Lean, Michael E J and Punab, Margus and Silman, Alan J and Vanderschueren, Dirk and Wu, Frederick C W},
  issn         = {1945-7197},
  language     = {eng},
  pages        = {1577--1587},
  publisher    = {ARRAY(0x85bbfb0)},
  series       = {The Journal of clinical endocrinology and metabolism},
  title        = {The Relationships between Sex Hormones and Sexual Function in Middle-Aged and Older European Men.},
  url          = {http://dx.doi.org/10.1210/jc.2010-2216},
  volume       = {96},
  year         = {2011},
}