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Hepatocellular Carcinoma Risk Factors and Disease Burden in a European Cohort: A Nested Case-Control Study.

Trichopoulos, Dimitrios; Bamia, Christina; Lagiou, Pagona; Fedirko, Veronika; Trepo, Elisabeth; Jenab, Mazda; Pischon, Tobias; Nöthlings, Ute; Overved, Kim and Tjønneland, Anne, et al. (2011) In Journal of the National Cancer Institute 103. p.1686-1695
Abstract
Background: To date, no attempt has been made to systematically determine the apportionment of the hepatocellular carcinoma burden in Europe or North America among established risk factors.MethodsUsing data collected from 1992 to 2006, which included 4 409 809 person-years in the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 125 case patients with hepatocellular carcinoma, of whom 115 were matched to 229 control subjects. We calculated odds ratios (ORs) for the association of documented risk factors for hepatocellular carcinoma with incidence of this disease and estimated their importance in this European cohort.ResultsChronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection (OR = 9.10, 95%... (More)
Background: To date, no attempt has been made to systematically determine the apportionment of the hepatocellular carcinoma burden in Europe or North America among established risk factors.MethodsUsing data collected from 1992 to 2006, which included 4 409 809 person-years in the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 125 case patients with hepatocellular carcinoma, of whom 115 were matched to 229 control subjects. We calculated odds ratios (ORs) for the association of documented risk factors for hepatocellular carcinoma with incidence of this disease and estimated their importance in this European cohort.ResultsChronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection (OR = 9.10, 95% confidence interval [CI] = 2.10 to 39.50 and OR = 13.36, 95% CI = 4.11 to 43.45, respectively), obesity (OR = 2.13, 95% CI = 1.06 to 4.29), former or current smoking (OR = 1.98, 95% CI = 0.90 to 4.39 and OR = 4.55, 95% CI = 1.90 to 10.91, respectively), and heavy alcohol intake (OR = 1.77, 95% CI = 0.73 to 4.27) were associated with hepatocellular carcinoma. Smoking contributed to almost half of all hepatocellular carcinomas (47.6%), whereas 13.2% and 20.9% were attributable to chronic HBV and HCV infection, respectively. Obesity and heavy alcohol intake contributed 16.1% and 10.2%, respectively. Almost two-thirds (65.7%, 95% CI = 50.6% to 79.3%) of hepatocellular carcinomas can be accounted for by exposure to at least one of these documented risk factors.ConclusionsSmoking contributed to more hepatocellular carcinomas in this Europe-wide cohort than chronic HBV and HCV infections. Heavy alcohol consumption and obesity also contributed to sizeable fractions of this disease burden. These contributions may be underestimates because EPIC volunteers are likely to be more health conscious than the general population. (Less)
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Journal of the National Cancer Institute
volume
103
pages
1686 - 1695
publisher
Oxford University Press
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  • WOS:000297209000010
  • PMID:22021666
  • Scopus:81855206498
ISSN
1460-2105
DOI
10.1093/jnci/djr395
language
English
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yes
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83af0069-5283-4599-8887-b0eff0850048 (old id 2200228)
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http://www.ncbi.nlm.nih.gov/pubmed/22021666?dopt=Abstract
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2011-11-02 12:42:21
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2016-11-27 04:27:57
@misc{83af0069-5283-4599-8887-b0eff0850048,
  abstract     = {Background: To date, no attempt has been made to systematically determine the apportionment of the hepatocellular carcinoma burden in Europe or North America among established risk factors.MethodsUsing data collected from 1992 to 2006, which included 4 409 809 person-years in the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 125 case patients with hepatocellular carcinoma, of whom 115 were matched to 229 control subjects. We calculated odds ratios (ORs) for the association of documented risk factors for hepatocellular carcinoma with incidence of this disease and estimated their importance in this European cohort.ResultsChronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection (OR = 9.10, 95% confidence interval [CI] = 2.10 to 39.50 and OR = 13.36, 95% CI = 4.11 to 43.45, respectively), obesity (OR = 2.13, 95% CI = 1.06 to 4.29), former or current smoking (OR = 1.98, 95% CI = 0.90 to 4.39 and OR = 4.55, 95% CI = 1.90 to 10.91, respectively), and heavy alcohol intake (OR = 1.77, 95% CI = 0.73 to 4.27) were associated with hepatocellular carcinoma. Smoking contributed to almost half of all hepatocellular carcinomas (47.6%), whereas 13.2% and 20.9% were attributable to chronic HBV and HCV infection, respectively. Obesity and heavy alcohol intake contributed 16.1% and 10.2%, respectively. Almost two-thirds (65.7%, 95% CI = 50.6% to 79.3%) of hepatocellular carcinomas can be accounted for by exposure to at least one of these documented risk factors.ConclusionsSmoking contributed to more hepatocellular carcinomas in this Europe-wide cohort than chronic HBV and HCV infections. Heavy alcohol consumption and obesity also contributed to sizeable fractions of this disease burden. These contributions may be underestimates because EPIC volunteers are likely to be more health conscious than the general population.},
  author       = {Trichopoulos, Dimitrios and Bamia, Christina and Lagiou, Pagona and Fedirko, Veronika and Trepo, Elisabeth and Jenab, Mazda and Pischon, Tobias and Nöthlings, Ute and Overved, Kim and Tjønneland, Anne and Outzen, Malene and Clavel-Chapelon, Francoise and Kaaks, Rudolf and Lukanova, Annekatrin and Boeing, Heiner and Aleksandrova, Krasimira and Benetou, Vassiliki and Zylis, Dimosthenis and Palli, Domenico and Pala, Valeria and Panico, Salvatore and Tumino, Rosario and Sacerdote, Carlotta and Bueno-De-Mesquita, H Bas and Van Kranen, Henk J and Peeters, Petra H M and Lund, Eiliv and Quirós, J Ramón and González, Carlos A and Sanchez Perez, Maria-Jose and Navarro, Carmen and Dorronsoro, Miren and Barricarte, Aurelio and Lindkvist, Björn and Regnér, Sara and Werner, Mårten and Hallmans, Göran and Khaw, Kay-Tee and Wareham, Nick and Key, Timothy and Romieu, Isabelle and Chuang, Shu-Chun and Murphy, Neil and Boffetta, Paolo and Trichopoulou, Antonia and Riboli, Elio},
  issn         = {1460-2105},
  language     = {eng},
  pages        = {1686--1695},
  publisher    = {ARRAY(0xa76cef0)},
  series       = {Journal of the National Cancer Institute},
  title        = {Hepatocellular Carcinoma Risk Factors and Disease Burden in a European Cohort: A Nested Case-Control Study.},
  url          = {http://dx.doi.org/10.1093/jnci/djr395},
  volume       = {103},
  year         = {2011},
}