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Three exceptional IgH/myc-translocation-carrying rat immunocytomas have breakpoints 50 to 80 kb 5' of c-myc

Axelson, H LU ; Panda, C K and Klein, G (1994) In International Journal of Cancer 56(3). p.21-418
Abstract

The spontaneously arising immunocytoma of the Louvain rat (RIC) carries a consistent chromosomal translocation between chromosomes 6 and 7. This translocation juxtaposes immunoglobulin heavy chain and c-myc sequences. In an earlier study on 14 RIC tumors, we found that the translocation breakpoint is located within 1.5 kb immediately upstream of c-myc in 10 of the tumors. Here we describe 3 exceptional tumors that had no rearrangement within 20 kb 5' of c-myc. Using pulsed-field gel electrophoresis we show that the translocation breakpoints in these tumors are located 50-80 kb 5' of c-myc and that c-myc rearranges to the 3' end of the IgH cluster.

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author
organization
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Cell Line, Chromosome Mapping, DNA, Neoplasm, Genes, Immunoglobulin, Genes, myc, Immunoglobulin Heavy Chains, Leukemia, Lymphocytic, Chronic, B-Cell, Multigene Family, Rats, Rats, Inbred Strains, Restriction Mapping, Translocation, Genetic, Tumor Cells, Cultured
in
International Journal of Cancer
volume
56
issue
3
pages
21 - 418
publisher
John Wiley & Sons
external identifiers
  • Scopus:0028269951
ISSN
0020-7136
language
English
LU publication?
yes
id
231c22e5-d5cd-4c22-a9d7-7cbad7dd2e90
date added to LUP
2016-08-09 09:19:28
date last changed
2016-08-11 14:43:41
@misc{231c22e5-d5cd-4c22-a9d7-7cbad7dd2e90,
  abstract     = {<p>The spontaneously arising immunocytoma of the Louvain rat (RIC) carries a consistent chromosomal translocation between chromosomes 6 and 7. This translocation juxtaposes immunoglobulin heavy chain and c-myc sequences. In an earlier study on 14 RIC tumors, we found that the translocation breakpoint is located within 1.5 kb immediately upstream of c-myc in 10 of the tumors. Here we describe 3 exceptional tumors that had no rearrangement within 20 kb 5' of c-myc. Using pulsed-field gel electrophoresis we show that the translocation breakpoints in these tumors are located 50-80 kb 5' of c-myc and that c-myc rearranges to the 3' end of the IgH cluster.</p>},
  author       = {Axelson, H and Panda, C K and Klein, G},
  issn         = {0020-7136},
  keyword      = {Animals,Cell Line,Chromosome Mapping,DNA, Neoplasm,Genes, Immunoglobulin,Genes, myc,Immunoglobulin Heavy Chains,Leukemia, Lymphocytic, Chronic, B-Cell,Multigene Family,Rats,Rats, Inbred Strains,Restriction Mapping,Translocation, Genetic,Tumor Cells, Cultured},
  language     = {eng},
  month        = {02},
  number       = {3},
  pages        = {21--418},
  publisher    = {ARRAY(0x9f6e618)},
  series       = {International Journal of Cancer},
  title        = {Three exceptional IgH/myc-translocation-carrying rat immunocytomas have breakpoints 50 to 80 kb 5' of c-myc},
  volume       = {56},
  year         = {1994},
}