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Duration of colonization with extended-spectrum beta-lactamase-producing Escherichia coli in patients with travellers' diarrhoea.

Tham, Johan LU ; Walder, Mats LU ; Melander, Eva LU and Odenholt, Inga LU (2012) In Scandinavian Journal of Infectious Diseases 44(8). p.573-577
Abstract
Background: Resistant Enterobacteriaceae have become a worldwide epidemic during the last decade and are a great threat to health care worldwide. International travel is a major risk factor for becoming colonized with extended-spectrum beta-lactamase (ESBL)-producing bacteria. Data on the persistence of colonization with ESBL-producing bacteria in the faecal flora are limited.Methods: A prospective cohort study was performed between October 2007 and October 2010. Fifty-eight patients with faecal carriage of ESBL-producing Escherichia coli from a previous study of patients with travellers' diarrhoea were included.Results: Forty-one of the patients had a complete follow-up. Ten of these patients (24%) carried ESBL-producing E. coli at the... (More)
Background: Resistant Enterobacteriaceae have become a worldwide epidemic during the last decade and are a great threat to health care worldwide. International travel is a major risk factor for becoming colonized with extended-spectrum beta-lactamase (ESBL)-producing bacteria. Data on the persistence of colonization with ESBL-producing bacteria in the faecal flora are limited.Methods: A prospective cohort study was performed between October 2007 and October 2010. Fifty-eight patients with faecal carriage of ESBL-producing Escherichia coli from a previous study of patients with travellers' diarrhoea were included.Results: Forty-one of the patients had a complete follow-up. Ten of these patients (24%) carried ESBL-producing E. coli at the first follow-up point (3-8 months), of whom 4 had a new ESBL strain. At the 3-y follow-up, 4 patients carried ESBL (10%), of whom 1 had 2 new ESBL strains.Conclusions: The long duration of ESBL carriage is worrisome. These carriers may be an important source of the spread of ESBLs in the population and this has implications for the clinical management of patients. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
44
issue
8
pages
573 - 577
publisher
Informa Healthcare
external identifiers
  • WOS:000306563500003
  • PMID:22292796
  • Scopus:84864033755
ISSN
1651-1980
DOI
10.3109/00365548.2011.653582
language
English
LU publication?
yes
id
a72e421e-1d6c-43ee-8702-bbcd78de1899 (old id 2367515)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22292796?dopt=Abstract
date added to LUP
2012-03-02 07:46:51
date last changed
2016-11-27 04:28:19
@misc{a72e421e-1d6c-43ee-8702-bbcd78de1899,
  abstract     = {Background: Resistant Enterobacteriaceae have become a worldwide epidemic during the last decade and are a great threat to health care worldwide. International travel is a major risk factor for becoming colonized with extended-spectrum beta-lactamase (ESBL)-producing bacteria. Data on the persistence of colonization with ESBL-producing bacteria in the faecal flora are limited.Methods: A prospective cohort study was performed between October 2007 and October 2010. Fifty-eight patients with faecal carriage of ESBL-producing Escherichia coli from a previous study of patients with travellers' diarrhoea were included.Results: Forty-one of the patients had a complete follow-up. Ten of these patients (24%) carried ESBL-producing E. coli at the first follow-up point (3-8 months), of whom 4 had a new ESBL strain. At the 3-y follow-up, 4 patients carried ESBL (10%), of whom 1 had 2 new ESBL strains.Conclusions: The long duration of ESBL carriage is worrisome. These carriers may be an important source of the spread of ESBLs in the population and this has implications for the clinical management of patients.},
  author       = {Tham, Johan and Walder, Mats and Melander, Eva and Odenholt, Inga},
  issn         = {1651-1980},
  language     = {eng},
  number       = {8},
  pages        = {573--577},
  publisher    = {ARRAY(0xa827c48)},
  series       = {Scandinavian Journal of Infectious Diseases},
  title        = {Duration of colonization with extended-spectrum beta-lactamase-producing Escherichia coli in patients with travellers' diarrhoea.},
  url          = {http://dx.doi.org/10.3109/00365548.2011.653582},
  volume       = {44},
  year         = {2012},
}