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A multivariate genetic analysis of specific phobia, separation anxiety and social phobia in early childhood

Eley, Thalia; Rijsdijk, Fruhling; Perrin, Sean LU ; O'Connor, Thomas and Bolton, Derek (2008) In Journal of Abnormal Child Psychology 36(6). p.839-848
Abstract
Background: Comorbidity amongst anxiety disorders is

very common in children as in adults and leads to

considerable distress and impairment, yet is poorly understood. Multivariate genetic analyses can shed light on the origins of this comorbidity by revealing whether genetic or environmental risks for one disorder also influence another. We examined the genetic and environmental influences on

the comorbidity between three common childhood anxiety disorders: Specific Phobia, Separation Anxiety and Social Phobia. Methods Using a two-phase design 4,662 twin-pairs were screened in the first phase and 854 pairs were assessed in

the second phase by maternal-informant diagnostic interview using DSM-IV criteria.... (More)
Background: Comorbidity amongst anxiety disorders is

very common in children as in adults and leads to

considerable distress and impairment, yet is poorly understood. Multivariate genetic analyses can shed light on the origins of this comorbidity by revealing whether genetic or environmental risks for one disorder also influence another. We examined the genetic and environmental influences on

the comorbidity between three common childhood anxiety disorders: Specific Phobia, Separation Anxiety and Social Phobia. Methods Using a two-phase design 4,662 twin-pairs were screened in the first phase and 854 pairs were assessed in

the second phase by maternal-informant diagnostic interview using DSM-IV criteria. Results: Multivariate genetic analysis revealed significant

shared environmental over-lap between Specific Phobia and Separation Anxiety and significant familial and non-shared environmental over-lap between Specific Phobia and Social Phobia.

Conclusions: Familial influences, especially shared environment, are central to the comorbidity between Specific Phobia and both Separation Anxiety and Social Phobia. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Twins, Genetics, Environment, Anxiety Disorders, Children
in
Journal of Abnormal Child Psychology
volume
36
issue
6
pages
839 - 848
publisher
Springer New York LLC
external identifiers
  • Scopus:47549113324
ISSN
0091-0627
DOI
10.1007/s10802-008-9216-x
language
English
LU publication?
no
id
ad0ad714-ac81-4d10-af01-10f8a076fbaf (old id 2373319)
date added to LUP
2012-03-21 13:55:23
date last changed
2016-11-06 04:29:27
@misc{ad0ad714-ac81-4d10-af01-10f8a076fbaf,
  abstract     = {Background: Comorbidity amongst anxiety disorders is<br/><br>
very common in children as in adults and leads to<br/><br>
considerable distress and impairment, yet is poorly understood. Multivariate genetic analyses can shed light on the origins of this comorbidity by revealing whether genetic or environmental risks for one disorder also influence another. We examined the genetic and environmental influences on<br/><br>
the comorbidity between three common childhood anxiety disorders: Specific Phobia, Separation Anxiety and Social Phobia. Methods Using a two-phase design 4,662 twin-pairs were screened in the first phase and 854 pairs were assessed in<br/><br>
the second phase by maternal-informant diagnostic interview using DSM-IV criteria. Results: Multivariate genetic analysis revealed significant<br/><br>
shared environmental over-lap between Specific Phobia and Separation Anxiety and significant familial and non-shared environmental over-lap between Specific Phobia and Social Phobia.<br/><br>
Conclusions: Familial influences, especially shared environment, are central to the comorbidity between Specific Phobia and both Separation Anxiety and Social Phobia.},
  author       = {Eley, Thalia and Rijsdijk, Fruhling and Perrin, Sean and O'Connor, Thomas and Bolton, Derek},
  issn         = {0091-0627},
  keyword      = {Twins,Genetics,Environment,Anxiety Disorders,Children},
  language     = {eng},
  number       = {6},
  pages        = {839--848},
  publisher    = {ARRAY(0x98d9d68)},
  series       = {Journal of Abnormal Child Psychology},
  title        = {A multivariate genetic analysis of specific phobia, separation anxiety and social phobia in early childhood},
  url          = {http://dx.doi.org/10.1007/s10802-008-9216-x},
  volume       = {36},
  year         = {2008},
}