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A Population-Based Study of Hepatitis D Virus as Potential Risk Factor for Hepatocellular Carcinoma.

Ji, Jianguang LU ; Sundquist, Kristina LU and Sundquist, Jan LU (2012) In Journal of the National Cancer Institute 104(10). p.790-792
Abstract
Hepatitis D virus (HDV) is dependent on the presence of hepatitis B virus (HBV) for transmission and replication because of its inability to produce its own coat. It remains unclear whether HDV infection increases the risk of hepatocellular carcinoma. Using the Swedish Hospital Discharge Register and Outpatient Registry, we identified 9160 patients with chronic HBV infection between 1997 and 2008, of whom 327 had chronic HDV infection and 323 had acute HDV infection. Standardized incidence ratios (SIRs) were calculated for these patients compared with the general population. The risk of hepatocellular carcinoma was greatly increased in patients with HBV and HDV (SIR = 137.17, 95% confidence interval [CI] = 62.19 to 261.51). The risk of... (More)
Hepatitis D virus (HDV) is dependent on the presence of hepatitis B virus (HBV) for transmission and replication because of its inability to produce its own coat. It remains unclear whether HDV infection increases the risk of hepatocellular carcinoma. Using the Swedish Hospital Discharge Register and Outpatient Registry, we identified 9160 patients with chronic HBV infection between 1997 and 2008, of whom 327 had chronic HDV infection and 323 had acute HDV infection. Standardized incidence ratios (SIRs) were calculated for these patients compared with the general population. The risk of hepatocellular carcinoma was greatly increased in patients with HBV and HDV (SIR = 137.17, 95% confidence interval [CI] = 62.19 to 261.51). The risk of hepatocellular carcinoma among patients with HBV and HDV was increased (SIR = 6.11, 95% CI = 2.77 to 11.65) when patients with chronic HBV infection alone were used as the reference population. Similar results were observed for patients with chronic HDV infection (SIR = 99.26, 95% CI = 42.39 to 196.55). Our findings indicate that HDV is a strong risk factor for hepatocellular carcinoma. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of the National Cancer Institute
volume
104
issue
10
pages
790 - 792
publisher
Oxford University Press
external identifiers
  • WOS:000304199600012
  • PMID:22423008
  • Scopus:84861325331
ISSN
1460-2105
DOI
10.1093/jnci/djs168
language
English
LU publication?
yes
id
559f01d7-9a1a-4e7e-b859-1c3606fe3aed (old id 2431725)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22423008?dopt=Abstract
date added to LUP
2012-04-03 11:20:22
date last changed
2016-10-23 04:29:20
@misc{559f01d7-9a1a-4e7e-b859-1c3606fe3aed,
  abstract     = {Hepatitis D virus (HDV) is dependent on the presence of hepatitis B virus (HBV) for transmission and replication because of its inability to produce its own coat. It remains unclear whether HDV infection increases the risk of hepatocellular carcinoma. Using the Swedish Hospital Discharge Register and Outpatient Registry, we identified 9160 patients with chronic HBV infection between 1997 and 2008, of whom 327 had chronic HDV infection and 323 had acute HDV infection. Standardized incidence ratios (SIRs) were calculated for these patients compared with the general population. The risk of hepatocellular carcinoma was greatly increased in patients with HBV and HDV (SIR = 137.17, 95% confidence interval [CI] = 62.19 to 261.51). The risk of hepatocellular carcinoma among patients with HBV and HDV was increased (SIR = 6.11, 95% CI = 2.77 to 11.65) when patients with chronic HBV infection alone were used as the reference population. Similar results were observed for patients with chronic HDV infection (SIR = 99.26, 95% CI = 42.39 to 196.55). Our findings indicate that HDV is a strong risk factor for hepatocellular carcinoma.},
  author       = {Ji, Jianguang and Sundquist, Kristina and Sundquist, Jan},
  issn         = {1460-2105},
  language     = {eng},
  number       = {10},
  pages        = {790--792},
  publisher    = {ARRAY(0xb144330)},
  series       = {Journal of the National Cancer Institute},
  title        = {A Population-Based Study of Hepatitis D Virus as Potential Risk Factor for Hepatocellular Carcinoma.},
  url          = {http://dx.doi.org/10.1093/jnci/djs168},
  volume       = {104},
  year         = {2012},
}