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The environment and the origins of islet autoimmunity and Type 1 diabetes.

Eringsmark Regnéll, S and Lernmark, Åke LU (2012) In Diabetic medicine : a journal of the British Diabetic Association
Abstract
Type 1 diabetes involves the specific destruction of the pancreatic islet β-cells, eventually resulting in a complete dependency of exogenous insulin. The clinical onset of diabetes is preceded by the appearance of autoantibodies against β-cell antigens. The human leukocyte antigen (HLA) region is the single most important genetic determinant of Type 1 diabetes susceptibility, yet variability in the HLA region has been estimated to explain only approximately 60% of the genetic influence of the disease. Over 50 identified non-HLA genetic polymorphisms support the notion that genetics alone cannot explain Type 1 diabetes. Several lines of evidence indicate that environmental triggers may be integral in inducing the onset of islet... (More)
Type 1 diabetes involves the specific destruction of the pancreatic islet β-cells, eventually resulting in a complete dependency of exogenous insulin. The clinical onset of diabetes is preceded by the appearance of autoantibodies against β-cell antigens. The human leukocyte antigen (HLA) region is the single most important genetic determinant of Type 1 diabetes susceptibility, yet variability in the HLA region has been estimated to explain only approximately 60% of the genetic influence of the disease. Over 50 identified non-HLA genetic polymorphisms support the notion that genetics alone cannot explain Type 1 diabetes. Several lines of evidence indicate that environmental triggers may be integral in inducing the onset of islet autoimmunity in genetically susceptible individuals. The association between environmental factors and the clinical onset is complicated by observation that the rate of progression to clinical onset may be affected by environmental determinants. Hence, the environment may be aetiological as well as pathogenic. Putative inductive mechanisms include viral, microbial, diet-related, anthropometric and psychosocial factors. Ongoing observational cohort studies such as The Environmental Determinants of Diabetes in the Young (TEDDY) study aim to ascertain environmental determinants that may trigger islet autoimmunity and either speed up or slow down the progression to clinical onset in subjects with persistent islet autoimmunity. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK. (Less)
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organization
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Contribution to journal
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published
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in
Diabetic medicine : a journal of the British Diabetic Association
publisher
Wiley-Blackwell
external identifiers
  • WOS:000313876500010
  • PMID:23252770
  • Scopus:84872734510
ISSN
1464-5491
DOI
10.1111/dme.12099
language
English
LU publication?
yes
id
85abdb8f-cd6f-438f-a2af-7d5eb271293b (old id 3347058)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23252770?dopt=Abstract
date added to LUP
2013-01-02 17:20:44
date last changed
2016-12-04 04:37:36
@misc{85abdb8f-cd6f-438f-a2af-7d5eb271293b,
  abstract     = {Type 1 diabetes involves the specific destruction of the pancreatic islet β-cells, eventually resulting in a complete dependency of exogenous insulin. The clinical onset of diabetes is preceded by the appearance of autoantibodies against β-cell antigens. The human leukocyte antigen (HLA) region is the single most important genetic determinant of Type 1 diabetes susceptibility, yet variability in the HLA region has been estimated to explain only approximately 60% of the genetic influence of the disease. Over 50 identified non-HLA genetic polymorphisms support the notion that genetics alone cannot explain Type 1 diabetes. Several lines of evidence indicate that environmental triggers may be integral in inducing the onset of islet autoimmunity in genetically susceptible individuals. The association between environmental factors and the clinical onset is complicated by observation that the rate of progression to clinical onset may be affected by environmental determinants. Hence, the environment may be aetiological as well as pathogenic. Putative inductive mechanisms include viral, microbial, diet-related, anthropometric and psychosocial factors. Ongoing observational cohort studies such as The Environmental Determinants of Diabetes in the Young (TEDDY) study aim to ascertain environmental determinants that may trigger islet autoimmunity and either speed up or slow down the progression to clinical onset in subjects with persistent islet autoimmunity. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK.},
  author       = {Eringsmark Regnéll, S and Lernmark, Åke},
  issn         = {1464-5491},
  language     = {eng},
  month        = {12},
  publisher    = {ARRAY(0xae59d28)},
  series       = {Diabetic medicine : a journal of the British Diabetic Association},
  title        = {The environment and the origins of islet autoimmunity and Type 1 diabetes.},
  url          = {http://dx.doi.org/10.1111/dme.12099},
  year         = {2012},
}