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Olfactory Dysfunction.

Puschmann, Andreas LU and Wszolek, Zbigniew K. (2013) In Parkinson's Disease and Nonmotor Dysfunction p.335-348
Abstract
Olfactory dysfunction is well documented as an early nonmotor manifestation of Parkinson’s disease (PD). This chapter outlines the anatomy and physiology of the olfactory system and summarizes the pathological changes in the olfactory system in PD. We review the occurrence of olfactory dysfunction in parkinsonian syndromes and familial parkinsonism. Different methods to assess olfactory function are presented. Their usefulness in routine clinical situations is limited to special diagnostic situations. However, these methods have provided important insights into the pathophysiology of parkinsonism and can help to identify at-risk groups for future neuroprotective trials. Several lines of evidence now suggest that olfactory disturbance... (More)
Olfactory dysfunction is well documented as an early nonmotor manifestation of Parkinson’s disease (PD). This chapter outlines the anatomy and physiology of the olfactory system and summarizes the pathological changes in the olfactory system in PD. We review the occurrence of olfactory dysfunction in parkinsonian syndromes and familial parkinsonism. Different methods to assess olfactory function are presented. Their usefulness in routine clinical situations is limited to special diagnostic situations. However, these methods have provided important insights into the pathophysiology of parkinsonism and can help to identify at-risk groups for future neuroprotective trials. Several lines of evidence now suggest that olfactory disturbance reflects Lewy pathology more closely than it reflects striatonigral dopamine deficiency. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Parkinson’s disease Olfaction Olfactory nerve Hyposmia
in
Parkinson's Disease and Nonmotor Dysfunction
editor
Pfeiffer, Ronald F. and Bodis-Wollner, Ivan
pages
335 - 348
publisher
Humana Press
ISBN
978-1-60761-429-6
978-1-60761-428-9
language
English
LU publication?
yes
id
bde00f96-8d91-46eb-921f-894497613b4a (old id 3516559)
alternative location
http://libris.kb.se/bib/13756476
date added to LUP
2013-03-06 15:45:58
date last changed
2016-09-26 14:45:43
@misc{bde00f96-8d91-46eb-921f-894497613b4a,
  abstract     = {Olfactory dysfunction is well documented as an early nonmotor manifestation of Parkinson’s disease (PD). This chapter outlines the anatomy and physiology of the olfactory system and summarizes the pathological changes in the olfactory system in PD. We review the occurrence of olfactory dysfunction in parkinsonian syndromes and familial parkinsonism. Different methods to assess olfactory function are presented. Their usefulness in routine clinical situations is limited to special diagnostic situations. However, these methods have provided important insights into the pathophysiology of parkinsonism and can help to identify at-risk groups for future neuroprotective trials. Several lines of evidence now suggest that olfactory disturbance reflects Lewy pathology more closely than it reflects striatonigral dopamine deficiency.},
  author       = {Puschmann, Andreas and Wszolek, Zbigniew K.},
  editor       = {Pfeiffer, Ronald F. and Bodis-Wollner, Ivan},
  isbn         = {978-1-60761-429-6},
  keyword      = {Parkinson’s disease Olfaction Olfactory nerve Hyposmia},
  language     = {eng},
  pages        = {335--348},
  publisher    = {ARRAY(0xa66e528)},
  series       = {Parkinson's Disease and Nonmotor Dysfunction},
  title        = {Olfactory Dysfunction.},
  year         = {2013},
}