A novel gene family encoding proteins with highly differing structure because of a rapidly evolving exon
(1995) In FEBS Letters 374(1). p.6-53- Abstract
- Despite vast differences in primary structure, it is here shown that several predominant semen proteins are encoded by genes that belongs to a common family. Members have their transcription unit split into three exons: the first encoding the signal peptide, the second the secreted protein, while the third exon solely consists of 3' non-translated nucleotides. The first and the third exon are conserved between members, but the second exon is not. The genes for human semenogelins I and II, rat SVSII, SVSIV, SVSV and guinea pig GP1 and GP2 belong to this gene family.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3965233
- author
- Lundwall, Åke LU and Lazure, C.
- organization
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- *Prostatic Secretory Proteins, *Multigene Family, Molecular Sequence Data, Male, Humans, Guinea Pigs, Gonadal Steroid Hormones/genetics, *Exons, Molecular, *Evolution, Dna, Conserved Sequence, Animals, Base Sequence, Proteins/*genetics, Rats, Research Support, Non-U.S. Gov't, *Semen, Seminal Plasma Proteins, Seminal Vesicle Secretory Proteins, Sequence Homology, Nucleic Acid
- in
- FEBS Letters
- volume
- 374
- issue
- 1
- pages
- 6 - 53
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:0028788899
- ISSN
- 1873-3468
- language
- English
- LU publication?
- yes
- additional info
- 1
- id
- 1a4a9e65-0dda-4fbb-8639-401772da7f90 (old id 3965233)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7589511
- date added to LUP
- 2016-04-04 13:05:11
- date last changed
- 2021-01-03 05:02:45
@article{1a4a9e65-0dda-4fbb-8639-401772da7f90, abstract = {{Despite vast differences in primary structure, it is here shown that several predominant semen proteins are encoded by genes that belongs to a common family. Members have their transcription unit split into three exons: the first encoding the signal peptide, the second the secreted protein, while the third exon solely consists of 3' non-translated nucleotides. The first and the third exon are conserved between members, but the second exon is not. The genes for human semenogelins I and II, rat SVSII, SVSIV, SVSV and guinea pig GP1 and GP2 belong to this gene family.}}, author = {{Lundwall, Åke and Lazure, C.}}, issn = {{1873-3468}}, keywords = {{*Prostatic Secretory Proteins; *Multigene Family; Molecular Sequence Data; Male; Humans; Guinea Pigs; Gonadal Steroid Hormones/genetics; *Exons; Molecular; *Evolution; Dna; Conserved Sequence; Animals; Base Sequence; Proteins/*genetics; Rats; Research Support; Non-U.S. Gov't; *Semen; Seminal Plasma Proteins; Seminal Vesicle Secretory Proteins; Sequence Homology; Nucleic Acid}}, language = {{eng}}, number = {{1}}, pages = {{6--53}}, publisher = {{Wiley-Blackwell}}, series = {{FEBS Letters}}, title = {{A novel gene family encoding proteins with highly differing structure because of a rapidly evolving exon}}, url = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7589511}}, volume = {{374}}, year = {{1995}}, }