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Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity: a randomized study.

Magnusdottir, O K; Landberg, R; Gunnarsdottir, I; Cloetens, L; Akesson, B; Landin-Olsson, Mona LU ; Rosqvist, F; Iggman, D; Schwab, U and Herzig, K-H, et al. (2014) In European Journal of Clinical Nutrition
Abstract
Background/Objectives:Few studies have used biomarkers of whole-grain intake to study its relation to glucose metabolism. We aimed to investigate the association between plasma alkylresorcinols (AR), a biomarker of whole-grain rye and wheat intake, and glucose metabolism in individuals with metabolic syndrome (MetS).Subjects/Methods:Participants were 30-65 years of age, with body mass index 27-40 kg/m(2) and had MetS without diabetes. Individuals were recruited through six centers in the Nordic countries and randomized to a healthy Nordic diet (ND, n=96), rich in whole-grain rye and wheat, or a control diet (n=70), for 18-24 weeks. In addition, associations between total plasma AR concentration and C17:0/C21:0 homolog ratio as an... (More)
Background/Objectives:Few studies have used biomarkers of whole-grain intake to study its relation to glucose metabolism. We aimed to investigate the association between plasma alkylresorcinols (AR), a biomarker of whole-grain rye and wheat intake, and glucose metabolism in individuals with metabolic syndrome (MetS).Subjects/Methods:Participants were 30-65 years of age, with body mass index 27-40 kg/m(2) and had MetS without diabetes. Individuals were recruited through six centers in the Nordic countries and randomized to a healthy Nordic diet (ND, n=96), rich in whole-grain rye and wheat, or a control diet (n=70), for 18-24 weeks. In addition, associations between total plasma AR concentration and C17:0/C21:0 homolog ratio as an indication of the relative whole-grain rye intake, and glucose metabolism measures from oral glucose tolerance tests were investigated in pooled (ND+control) regression analyses at 18/24 weeks.Results:ND did not improve glucose metabolism compared with control diet, but the AR C17:0/C21:0 ratio was inversely associated with fasting insulin concentrations (P=0.002) and positively associated with the insulin sensitivity indices Matsuda ISI (P=0.026) and disposition index (P=0.022) in pooled analyses at 18/24 weeks, even after adjustment for confounders. The AR C17:0/C21:0 ratio was not significantly associated with insulin secretion indices. Total plasma AR concentration was not related to fasting plasma glucose or fasting insulin at 18/24 weeks.Conclusions:The AR C17:0/C21:0 ratio, an indicator of relative whole-grain rye intake, is associated with increased insulin sensitivity in a population with MetS.European Journal of Clinical Nutrition advance online publication, 19 February 2014; doi:10.1038/ejcn.2014.12. (Less)
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European Journal of Clinical Nutrition
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Nature Publishing Group
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  • PMID:24549027
  • WOS:000333777700008
  • Scopus:84898006773
ISSN
1476-5640
DOI
10.1038/ejcn.2014.12
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English
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yes
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e11f1ce7-0d60-42d6-8d10-9eb36a449d87 (old id 4334477)
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http://www.ncbi.nlm.nih.gov/pubmed/24549027?dopt=Abstract
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2014-03-05 22:04:09
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2016-10-13 04:36:35
@misc{e11f1ce7-0d60-42d6-8d10-9eb36a449d87,
  abstract     = {Background/Objectives:Few studies have used biomarkers of whole-grain intake to study its relation to glucose metabolism. We aimed to investigate the association between plasma alkylresorcinols (AR), a biomarker of whole-grain rye and wheat intake, and glucose metabolism in individuals with metabolic syndrome (MetS).Subjects/Methods:Participants were 30-65 years of age, with body mass index 27-40 kg/m(2) and had MetS without diabetes. Individuals were recruited through six centers in the Nordic countries and randomized to a healthy Nordic diet (ND, n=96), rich in whole-grain rye and wheat, or a control diet (n=70), for 18-24 weeks. In addition, associations between total plasma AR concentration and C17:0/C21:0 homolog ratio as an indication of the relative whole-grain rye intake, and glucose metabolism measures from oral glucose tolerance tests were investigated in pooled (ND+control) regression analyses at 18/24 weeks.Results:ND did not improve glucose metabolism compared with control diet, but the AR C17:0/C21:0 ratio was inversely associated with fasting insulin concentrations (P=0.002) and positively associated with the insulin sensitivity indices Matsuda ISI (P=0.026) and disposition index (P=0.022) in pooled analyses at 18/24 weeks, even after adjustment for confounders. The AR C17:0/C21:0 ratio was not significantly associated with insulin secretion indices. Total plasma AR concentration was not related to fasting plasma glucose or fasting insulin at 18/24 weeks.Conclusions:The AR C17:0/C21:0 ratio, an indicator of relative whole-grain rye intake, is associated with increased insulin sensitivity in a population with MetS.European Journal of Clinical Nutrition advance online publication, 19 February 2014; doi:10.1038/ejcn.2014.12.},
  author       = {Magnusdottir, O K and Landberg, R and Gunnarsdottir, I and Cloetens, L and Akesson, B and Landin-Olsson, Mona and Rosqvist, F and Iggman, D and Schwab, U and Herzig, K-H and Savolainen, M J and Brader, L and Hermansen, K and Kolehmainen, M and Poutanen, K and Uusitupa, M and Thorsdottir, I and Risérus, U},
  issn         = {1476-5640},
  language     = {eng},
  month        = {02},
  publisher    = {ARRAY(0xa0e3ac8)},
  series       = {European Journal of Clinical Nutrition},
  title        = {Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity: a randomized study.},
  url          = {http://dx.doi.org/10.1038/ejcn.2014.12},
  year         = {2014},
}