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Hypertension, haematuria and renal functioning in haemophilia - a cross-sectional study in Europe

Holme, P. A.; Combescure, C.; Tait, R. C.; Berntorp, E. LU ; Rauchensteiner, S. and de Moerloose, P. (2016) In Haemophilia 22(2). p.248-255
Abstract

Background and objectives: This cross-sectional, epidemiological study sought to assess the prevalence and extent of potential risk factors for hypertension, particularly renal function related to haematuria and their associations in people with haemophilia. Methodology: Demographic and medical data were collected at a single time-point in patients with haemophilia over 40 years of age from 16 European centres. Associations with diagnosis of hypertension were tested in univariate and multivariate analyses. Results: We enrolled 532 patients (median age 52 years, range 40-98) with haemophilia A (n = 467) or haemophilia B (n = 65). Haemophilia was severe (-1) in 313 patients (59%). Hypertension was diagnosed in 239 patients (45%). In... (More)

Background and objectives: This cross-sectional, epidemiological study sought to assess the prevalence and extent of potential risk factors for hypertension, particularly renal function related to haematuria and their associations in people with haemophilia. Methodology: Demographic and medical data were collected at a single time-point in patients with haemophilia over 40 years of age from 16 European centres. Associations with diagnosis of hypertension were tested in univariate and multivariate analyses. Results: We enrolled 532 patients (median age 52 years, range 40-98) with haemophilia A (n = 467) or haemophilia B (n = 65). Haemophilia was severe (-1) in 313 patients (59%). Hypertension was diagnosed in 239 patients (45%). In multivariate analyses, age and body mass index (BMI) were significantly and independently associated with hypertension (adjusted odds ratio (OR) 18.1, P <0.001, in elderly patients and OR = 25.1, P <0.001, in patients with BMI >30 kg m-2). Estimated glomerular filtration rate (eGFR) -1 (OR = 2.7, P = 0.047) was significantly associated with hypertension, but mean eGFR was significantly higher for severe than mild haemophilia. Further variables with OR > 2.8 were diabetes (OR = 2.8, P = 0.04), coronary artery disease (OR = 3.3, P = 0.052) and family history of hypertension (OR = 4.4, P <0.001). Neither severity of haemophilia nor history of haematuria was significantly associated with hypertension in univariate or multivariate analyses. Conclusion: As in the general population, age and BMI were major risk factors for hypertension in people with haemophilia. Renal dysfunction was associated with hypertension, but the prevalence of renal dysfunction was not extensive and furthermore not significantly correlated with haematuria. The associations of other variables with hypertension require further studies to confirm causal relationships over time.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiovascular disease, Epidemiological study, Haematuria, Haemophilia, Hypertension, Renal disease
in
Haemophilia
volume
22
issue
2
pages
8 pages
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • Scopus:84960419371
ISSN
1351-8216
DOI
10.1111/hae.12847
language
English
LU publication?
yes
id
450cc2f5-c5ed-4831-83cf-9f9f3ec67d2f
date added to LUP
2016-07-25 14:47:30
date last changed
2016-10-23 04:44:50
@misc{450cc2f5-c5ed-4831-83cf-9f9f3ec67d2f,
  abstract     = {<p>Background and objectives: This cross-sectional, epidemiological study sought to assess the prevalence and extent of potential risk factors for hypertension, particularly renal function related to haematuria and their associations in people with haemophilia. Methodology: Demographic and medical data were collected at a single time-point in patients with haemophilia over 40 years of age from 16 European centres. Associations with diagnosis of hypertension were tested in univariate and multivariate analyses. Results: We enrolled 532 patients (median age 52 years, range 40-98) with haemophilia A (n = 467) or haemophilia B (n = 65). Haemophilia was severe (-1) in 313 patients (59%). Hypertension was diagnosed in 239 patients (45%). In multivariate analyses, age and body mass index (BMI) were significantly and independently associated with hypertension (adjusted odds ratio (OR) 18.1, P &lt;0.001, in elderly patients and OR = 25.1, P &lt;0.001, in patients with BMI &gt;30 kg m<sup>-2</sup>). Estimated glomerular filtration rate (eGFR) -1 (OR = 2.7, P = 0.047) was significantly associated with hypertension, but mean eGFR was significantly higher for severe than mild haemophilia. Further variables with OR &gt; 2.8 were diabetes (OR = 2.8, P = 0.04), coronary artery disease (OR = 3.3, P = 0.052) and family history of hypertension (OR = 4.4, P &lt;0.001). Neither severity of haemophilia nor history of haematuria was significantly associated with hypertension in univariate or multivariate analyses. Conclusion: As in the general population, age and BMI were major risk factors for hypertension in people with haemophilia. Renal dysfunction was associated with hypertension, but the prevalence of renal dysfunction was not extensive and furthermore not significantly correlated with haematuria. The associations of other variables with hypertension require further studies to confirm causal relationships over time.</p>},
  author       = {Holme, P. A. and Combescure, C. and Tait, R. C. and Berntorp, E. and Rauchensteiner, S. and de Moerloose, P.},
  issn         = {1351-8216},
  keyword      = {Cardiovascular disease,Epidemiological study,Haematuria,Haemophilia,Hypertension,Renal disease},
  language     = {eng},
  month        = {03},
  number       = {2},
  pages        = {248--255},
  publisher    = {ARRAY(0x9998eb0)},
  series       = {Haemophilia},
  title        = {Hypertension, haematuria and renal functioning in haemophilia - a cross-sectional study in Europe},
  url          = {http://dx.doi.org/10.1111/hae.12847},
  volume       = {22},
  year         = {2016},
}