A Scalable Formulation for Engineering Combination Therapies for Evolutionary Dynamics of Disease
Jonsson, Vanessa ; Rantzer, Anders LU
and Murray, Richard M.
(2014)
American Control Conference, 2014
- Abstract
- It has been shown that optimal controller synthesis for positive systems can be formulated as a linear program. Leveraging these results, we propose a scalable iterative algorithm for the systematic design of sparse, small gain feedback strategies that stabilize the evolutionary dynamics of a generic disease model. We achieve the desired feedback structure by augmenting the optimization problems with l1 and l2 regularization terms, and illustrate our method on an example inspired by an experimental study aimed at finding appropriate HIV neutralizing antibody therapy combinations in the presence of escape mutants.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4933540
- author
- Jonsson, Vanessa
; Rantzer, Anders
LU
and Murray, Richard M.
- organization
- publishing date
- 2014
- type
- Contribution to conference
- publication status
- published
- subject
- conference name
- American Control Conference, 2014
- conference location
- Portland, OR, United States
- conference dates
- 2014-06-04 - 2014-06-06
- external identifiers
-
- scopus:84905695086
- project
- LCCC
- language
- English
- LU publication?
- yes
- id
- cda2b482-da78-417b-8866-82069077427a (old id 4933540)
- date added to LUP
- 2016-04-04 13:50:42
- date last changed
- 2023-11-16 11:11:32
@misc{cda2b482-da78-417b-8866-82069077427a,
abstract = {{It has been shown that optimal controller synthesis for positive systems can be formulated as a linear program. Leveraging these results, we propose a scalable iterative algorithm for the systematic design of sparse, small gain feedback strategies that stabilize the evolutionary dynamics of a generic disease model. We achieve the desired feedback structure by augmenting the optimization problems with l1 and l2 regularization terms, and illustrate our method on an example inspired by an experimental study aimed at finding appropriate HIV neutralizing antibody therapy combinations in the presence of escape mutants.}},
author = {{Jonsson, Vanessa and Rantzer, Anders and Murray, Richard M.}},
language = {{eng}},
title = {{A Scalable Formulation for Engineering Combination Therapies for Evolutionary Dynamics of Disease}},
year = {{2014}},
}