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Factors limiting physical working capacity in predialytic uraemic patients

Clyne, N. LU ; Jogestrand, T.; Lins, L. E.; Pehrsson, S. K. and Ekelund, L. G. (1987) In Acta Medica Scandinavica 222(2). p.183-190
Abstract

The exercise capacity of 20 predialytic uraemic patients (mean age 43 ± 12 years) was studied prospectively. Nine of these patients were examined twice in a longitudinal study. The maximal working capacity, measured by standardized exercise test on a bicycle ergometer, averaged 74 ± 19% of the expected normal. Normal exercise ECG were registered in 16 out of 20 patients. Total hemoglobin/kg body weight (THb) was 67 ± 16% of the expected normal and serum parathyroid hormone concentration (PTH) was 39 ± 39 μg/l (normal range 0.5-1.5). Partial correlation showed a correlation between exercise capacity and PTH (p <0.05). In the longitudinal study the decrease in steady state exercise capacity was correlated to the decrease in THb (p... (More)

The exercise capacity of 20 predialytic uraemic patients (mean age 43 ± 12 years) was studied prospectively. Nine of these patients were examined twice in a longitudinal study. The maximal working capacity, measured by standardized exercise test on a bicycle ergometer, averaged 74 ± 19% of the expected normal. Normal exercise ECG were registered in 16 out of 20 patients. Total hemoglobin/kg body weight (THb) was 67 ± 16% of the expected normal and serum parathyroid hormone concentration (PTH) was 39 ± 39 μg/l (normal range 0.5-1.5). Partial correlation showed a correlation between exercise capacity and PTH (p <0.05). In the longitudinal study the decrease in steady state exercise capacity was correlated to the decrease in THb (p <0.05), but not to the increase in PTH. In conclusion, patients with predialytic uraemia have a reduced maximal working capacity, due to several possible factors one of which is a reduced THb. Ischaemic heart disease seems to be of minor importance.

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author
publishing date
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Contribution to journal
publication status
published
in
Acta Medica Scandinavica
volume
222
issue
2
pages
8 pages
publisher
Norstedts
external identifiers
  • Scopus:0023183584
ISSN
0001-6101
language
English
LU publication?
no
id
4d5104ac-f3ea-4b70-b1a3-a832c0157665
date added to LUP
2016-08-30 22:10:31
date last changed
2016-09-16 15:09:51
@misc{4d5104ac-f3ea-4b70-b1a3-a832c0157665,
  abstract     = {<p>The exercise capacity of 20 predialytic uraemic patients (mean age 43 ± 12 years) was studied prospectively. Nine of these patients were examined twice in a longitudinal study. The maximal working capacity, measured by standardized exercise test on a bicycle ergometer, averaged 74 ± 19% of the expected normal. Normal exercise ECG were registered in 16 out of 20 patients. Total hemoglobin/kg body weight (THb) was 67 ± 16% of the expected normal and serum parathyroid hormone concentration (PTH) was 39 ± 39 μg/l (normal range 0.5-1.5). Partial correlation showed a correlation between exercise capacity and PTH (p &lt;0.05). In the longitudinal study the decrease in steady state exercise capacity was correlated to the decrease in THb (p &lt;0.05), but not to the increase in PTH. In conclusion, patients with predialytic uraemia have a reduced maximal working capacity, due to several possible factors one of which is a reduced THb. Ischaemic heart disease seems to be of minor importance.</p>},
  author       = {Clyne, N. and Jogestrand, T. and Lins, L. E. and Pehrsson, S. K. and Ekelund, L. G.},
  issn         = {0001-6101},
  language     = {eng},
  number       = {2},
  pages        = {183--190},
  publisher    = {ARRAY(0x21e5f38)},
  series       = {Acta Medica Scandinavica},
  title        = {Factors limiting physical working capacity in predialytic uraemic patients},
  volume       = {222},
  year         = {1987},
}