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RNA Binding Proteins that Control Human Papillomavirus Gene Expression.

Kajitani, Naoko LU and Schwartz, Stefan LU (2015) In Biomolecules 5(2). p.758-774
Abstract
The human papillomavirus (HPV) life cycle is strictly linked to the differentiation program of the infected mucosal epithelial cell. In the basal and lower levels of the epithelium, early genes coding for pro-mitotic proteins and viral replication factors are expressed, while terminal cell differentiation is required for activation of late gene expression and production of viral particles at the very top of the epithelium. Such productive infections are normally cleared within 18-24 months. In rare cases, the HPV infection is stuck in the early stage of the infection. Such infections may give rise to cervical lesions that can progress to cancer, primarily cancer of the uterine cervix. Since cancer progression is strictly linked to HPV gene... (More)
The human papillomavirus (HPV) life cycle is strictly linked to the differentiation program of the infected mucosal epithelial cell. In the basal and lower levels of the epithelium, early genes coding for pro-mitotic proteins and viral replication factors are expressed, while terminal cell differentiation is required for activation of late gene expression and production of viral particles at the very top of the epithelium. Such productive infections are normally cleared within 18-24 months. In rare cases, the HPV infection is stuck in the early stage of the infection. Such infections may give rise to cervical lesions that can progress to cancer, primarily cancer of the uterine cervix. Since cancer progression is strictly linked to HPV gene expression, it is of interest to understand how HPV gene expression is regulated. Cis-acting HPV RNA elements and cellular RNA-binding proteins control HPV mRNA splicing and polyadenylation. These interactions are believed to play a particularly important role in the switch from early to late gene expression, thereby contributing to the pathogenesis of HPV. Indeed, it has been shown that the levels of various RNA binding proteins change in response to differentiation and in response to HPV induced cervical lesions and cancer. Here we have compiled published data on RNA binding proteins involved in the regulation of HPV gene expression. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biomolecules
volume
5
issue
2
pages
758 - 774
publisher
Multidisciplinary Digital Publishing Institute (MDPI)
external identifiers
  • PMID:25950509
ISSN
2218-273X
DOI
10.3390/biom5020758
language
English
LU publication?
yes
id
ffd0ecd5-e929-430c-9cd7-cb5ab47768ad (old id 5456737)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25950509?dopt=Abstract
date added to LUP
2015-06-02 15:53:11
date last changed
2016-11-28 11:36:00
@misc{ffd0ecd5-e929-430c-9cd7-cb5ab47768ad,
  abstract     = {The human papillomavirus (HPV) life cycle is strictly linked to the differentiation program of the infected mucosal epithelial cell. In the basal and lower levels of the epithelium, early genes coding for pro-mitotic proteins and viral replication factors are expressed, while terminal cell differentiation is required for activation of late gene expression and production of viral particles at the very top of the epithelium. Such productive infections are normally cleared within 18-24 months. In rare cases, the HPV infection is stuck in the early stage of the infection. Such infections may give rise to cervical lesions that can progress to cancer, primarily cancer of the uterine cervix. Since cancer progression is strictly linked to HPV gene expression, it is of interest to understand how HPV gene expression is regulated. Cis-acting HPV RNA elements and cellular RNA-binding proteins control HPV mRNA splicing and polyadenylation. These interactions are believed to play a particularly important role in the switch from early to late gene expression, thereby contributing to the pathogenesis of HPV. Indeed, it has been shown that the levels of various RNA binding proteins change in response to differentiation and in response to HPV induced cervical lesions and cancer. Here we have compiled published data on RNA binding proteins involved in the regulation of HPV gene expression.},
  author       = {Kajitani, Naoko and Schwartz, Stefan},
  issn         = {2218-273X},
  language     = {eng},
  number       = {2},
  pages        = {758--774},
  publisher    = {ARRAY(0x940a9d8)},
  series       = {Biomolecules},
  title        = {RNA Binding Proteins that Control Human Papillomavirus Gene Expression.},
  url          = {http://dx.doi.org/10.3390/biom5020758},
  volume       = {5},
  year         = {2015},
}