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Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions.

Saxne, Tore LU and Heinegård, Dick LU (1992) In Arthritis and Rheumatism 35(4). p.385-390
Abstract
OBJECTIVE:

To investigate whether fragmentation of proteoglycans in arthritis results in domains that have different levels of release from cartilage at different stages of the disease.

METHODS:

Two regions of the proteoglycan, the hyaluronan-binding region and the glycosaminoglycan-rich region of the core protein, were measured, by immunoassay, in knee joint synovial fluids of patients with rheumatoid arthritis or reactive arthritis.

RESULTS:

Synovial fluid concentrations of the glycosaminoglycan-rich region were highest in rheumatoid arthritis patients who had little cartilage damage as determined by radiography, whereas release of the hyaluronan-binding region predominated in patients with... (More)
OBJECTIVE:

To investigate whether fragmentation of proteoglycans in arthritis results in domains that have different levels of release from cartilage at different stages of the disease.

METHODS:

Two regions of the proteoglycan, the hyaluronan-binding region and the glycosaminoglycan-rich region of the core protein, were measured, by immunoassay, in knee joint synovial fluids of patients with rheumatoid arthritis or reactive arthritis.

RESULTS:

Synovial fluid concentrations of the glycosaminoglycan-rich region were highest in rheumatoid arthritis patients who had little cartilage damage as determined by radiography, whereas release of the hyaluronan-binding region predominated in patients with advanced cartilage destruction. In reactive arthritis, release of the glycosaminoglycan-rich region predominated.

CONCLUSION:

These findings indicate that the hyaluronan-binding region is initially retained in the tissue during the development of cartilage destruction. The combined analysis of these markers offers a new avenue for assessment of the degree of cartilage damage in arthritis.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Synovial fluid, proteoglycans
in
Arthritis and Rheumatism
volume
35
issue
4
pages
385 - 390
publisher
John Wiley & Sons
external identifiers
  • Scopus:0026710173
ISSN
1529-0131
language
English
LU publication?
yes
id
634372ed-967f-44f5-b210-7b27ebb8476b
date added to LUP
2016-05-07 09:44:05
date last changed
2016-12-04 04:51:22
@misc{634372ed-967f-44f5-b210-7b27ebb8476b,
  abstract     = {OBJECTIVE: <br/><br/>To investigate whether fragmentation of proteoglycans in arthritis results in domains that have different levels of release from cartilage at different stages of the disease.<br/><br/>METHODS: <br/><br/>Two regions of the proteoglycan, the hyaluronan-binding region and the glycosaminoglycan-rich region of the core protein, were measured, by immunoassay, in knee joint synovial fluids of patients with rheumatoid arthritis or reactive arthritis.<br/><br/>RESULTS: <br/><br/>Synovial fluid concentrations of the glycosaminoglycan-rich region were highest in rheumatoid arthritis patients who had little cartilage damage as determined by radiography, whereas release of the hyaluronan-binding region predominated in patients with advanced cartilage destruction. In reactive arthritis, release of the glycosaminoglycan-rich region predominated.<br/><br/>CONCLUSION: <br/><br/>These findings indicate that the hyaluronan-binding region is initially retained in the tissue during the development of cartilage destruction. The combined analysis of these markers offers a new avenue for assessment of the degree of cartilage damage in arthritis.<br/>},
  author       = {Saxne, Tore and Heinegård, Dick},
  issn         = {1529-0131},
  keyword      = {Synovial fluid,proteoglycans},
  language     = {eng},
  number       = {4},
  pages        = {385--390},
  publisher    = {ARRAY(0xa5d23a8)},
  series       = {Arthritis and Rheumatism},
  title        = {Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions.},
  volume       = {35},
  year         = {1992},
}