Advanced

Correlation between karyotypic pattern and clincopathologic features in 125 breast cancer cases

Pandis, N; Idvall, I LU ; Bardi, G; Jin, Y LU ; Gorunova, L LU ; Mertens, F LU ; Olsson, Håkan LU ; Ingvar, C LU ; Beroukas, K and Mitelman, F LU , et al. (1996) In International Journal of Cancer 66(2). p.6-191
Abstract

A correlation analysis was performed on 125 cytogenetically characterized breast cancer cases to assess the relationship between the tumor karyotype and clinicopathologic features. The carcinomas of young women had a higher modal chromosome number than those of older women. The number of chromosomal aberrations and modal chromosome number were also found to correlate with the histologic type, grade and mitotic activity of the tumor. Whereas all lobular carcinomas were karyotypically normal or near-diploid, more than 3 aberrations and sometimes near-triploid or near-tetraploid karyotypes were common findings in ductal carcinomas, especially in grade-III tumors and in tumors showing high mitotic activity in vivo. Karyotypes with... (More)

A correlation analysis was performed on 125 cytogenetically characterized breast cancer cases to assess the relationship between the tumor karyotype and clinicopathologic features. The carcinomas of young women had a higher modal chromosome number than those of older women. The number of chromosomal aberrations and modal chromosome number were also found to correlate with the histologic type, grade and mitotic activity of the tumor. Whereas all lobular carcinomas were karyotypically normal or near-diploid, more than 3 aberrations and sometimes near-triploid or near-tetraploid karyotypes were common findings in ductal carcinomas, especially in grade-III tumors and in tumors showing high mitotic activity in vivo. Karyotypes with cytogenetically unregulated clones and unbalanced structural chromosomal rearrangements were more frequent in infiltrating than in in situ carcinomas but, at least as far as the second of these 2 characteristics is concerned, especially in infiltrating carcinomas that also had an in situ component. The presence of cytogenetic polyclonality correlated with tumor grade. Although recurrent chromosome aberrations were significantly more common in ductal than in lobular carcinomas, none of these breast cancer-associated anomalies seemed to be specific for any particular clinicopathologic parameter. The associations between modal chromosome number and mitotic activity and between cytogenetic polyclonality and tumor grade were found to be statistically significant in multivariate models. No correlations was seen between the karyotypic findings and tumor size or the presence of axillary-lymph-node metastases.

(Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Aged, Aged, 80 and over, Breast Neoplasms, Chromosome Aberrations, Female, Humans, Karyotyping, Middle Aged
in
International Journal of Cancer
volume
66
issue
2
pages
6 pages
publisher
John Wiley & Sons
external identifiers
  • Scopus:8944224017
ISSN
0020-7136
DOI
10.1002/(SICI)1097-0215(19960410)66:2<191::AID-IJC9>3.0.CO;2-Y
language
English
LU publication?
yes
id
67b8b124-0b2d-4e6d-b3a8-90e58e6b4b08
date added to LUP
2016-09-18 12:52:39
date last changed
2016-10-13 05:13:49
@misc{67b8b124-0b2d-4e6d-b3a8-90e58e6b4b08,
  abstract     = {<p>A correlation analysis was performed on 125 cytogenetically characterized breast cancer cases to assess the relationship between the tumor karyotype and clinicopathologic features. The carcinomas of young women had a higher modal chromosome number than those of older women. The number of chromosomal aberrations and modal chromosome number were also found to correlate with the histologic type, grade and mitotic activity of the tumor. Whereas all lobular carcinomas were karyotypically normal or near-diploid, more than 3 aberrations and sometimes near-triploid or near-tetraploid karyotypes were common findings in ductal carcinomas, especially in grade-III tumors and in tumors showing high mitotic activity in vivo. Karyotypes with cytogenetically unregulated clones and unbalanced structural chromosomal rearrangements were more frequent in infiltrating than in in situ carcinomas but, at least as far as the second of these 2 characteristics is concerned, especially in infiltrating carcinomas that also had an in situ component. The presence of cytogenetic polyclonality correlated with tumor grade. Although recurrent chromosome aberrations were significantly more common in ductal than in lobular carcinomas, none of these breast cancer-associated anomalies seemed to be specific for any particular clinicopathologic parameter. The associations between modal chromosome number and mitotic activity and between cytogenetic polyclonality and tumor grade were found to be statistically significant in multivariate models. No correlations was seen between the karyotypic findings and tumor size or the presence of axillary-lymph-node metastases.</p>},
  author       = {Pandis, N and Idvall, I and Bardi, G and Jin, Y and Gorunova, L and Mertens, F and Olsson, Håkan and Ingvar, C and Beroukas, K and Mitelman, F and Heim, S},
  issn         = {0020-7136},
  keyword      = {Adult,Aged,Aged, 80 and over,Breast Neoplasms,Chromosome Aberrations,Female,Humans,Karyotyping,Middle Aged},
  language     = {eng},
  month        = {04},
  number       = {2},
  pages        = {6--191},
  publisher    = {ARRAY(0xb480930)},
  series       = {International Journal of Cancer},
  title        = {Correlation between karyotypic pattern and clincopathologic features in 125 breast cancer cases},
  url          = {http://dx.doi.org/10.1002/(SICI)1097-0215(19960410)66:2<191::AID-IJC9>3.0.CO;2-Y},
  volume       = {66},
  year         = {1996},
}