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Directed vaccination against pneumococcal disease

Li, Yi; Hill, Andrew; Beitelshees, Marie; Shao, Shuai; Lovell, Jonathan F; Davidson, Bruce A; Knight, Paul R; Hakansson, Anders P LU ; Pfeifer, Blaine A and Jones, Charles H (2016) In Proceedings of the National Academy of Sciences 113(25). p.6898-6903
Abstract

Immunization strategies against commensal bacterial pathogens have long focused on eradicating asymptomatic carriage as well as disease, resulting in changes in the colonizing microflora with unknown future consequences. Additionally, current vaccines are not easily adaptable to sequence diversity and immune evasion. Here, we present a "smart" vaccine that leverages our current understanding of disease transition from bacterial carriage to infection with the pneumococcus serving as a model organism. Using conserved surface proteins highly expressed during virulent transition, the vaccine mounts an immune response specifically against disease-causing bacterial populations without affecting carriage. Aided by a delivery technology capable... (More)

Immunization strategies against commensal bacterial pathogens have long focused on eradicating asymptomatic carriage as well as disease, resulting in changes in the colonizing microflora with unknown future consequences. Additionally, current vaccines are not easily adaptable to sequence diversity and immune evasion. Here, we present a "smart" vaccine that leverages our current understanding of disease transition from bacterial carriage to infection with the pneumococcus serving as a model organism. Using conserved surface proteins highly expressed during virulent transition, the vaccine mounts an immune response specifically against disease-causing bacterial populations without affecting carriage. Aided by a delivery technology capable of multivalent surface display, which can be adapted easily to a changing clinical picture, results include complete protection against the development of pneumonia and sepsis during animal challenge experiments with multiple, highly variable, and clinically relevant pneumococcal isolates. The approach thus offers a unique and dynamic treatment option readily adaptable to other commensal pathogens.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Proceedings of the National Academy of Sciences
volume
113
issue
25
pages
6 pages
publisher
National Academy of Sciences
external identifiers
  • Scopus:84975761292
ISSN
1091-6490
DOI
10.1073/pnas.1603007113
language
English
LU publication?
yes
id
77bccb69-2068-4d26-841b-79003b1f1a5b
date added to LUP
2016-06-28 10:17:23
date last changed
2016-11-17 08:12:54
@misc{77bccb69-2068-4d26-841b-79003b1f1a5b,
  abstract     = {<p>Immunization strategies against commensal bacterial pathogens have long focused on eradicating asymptomatic carriage as well as disease, resulting in changes in the colonizing microflora with unknown future consequences. Additionally, current vaccines are not easily adaptable to sequence diversity and immune evasion. Here, we present a "smart" vaccine that leverages our current understanding of disease transition from bacterial carriage to infection with the pneumococcus serving as a model organism. Using conserved surface proteins highly expressed during virulent transition, the vaccine mounts an immune response specifically against disease-causing bacterial populations without affecting carriage. Aided by a delivery technology capable of multivalent surface display, which can be adapted easily to a changing clinical picture, results include complete protection against the development of pneumonia and sepsis during animal challenge experiments with multiple, highly variable, and clinically relevant pneumococcal isolates. The approach thus offers a unique and dynamic treatment option readily adaptable to other commensal pathogens.</p>},
  author       = {Li, Yi and Hill, Andrew and Beitelshees, Marie and Shao, Shuai and Lovell, Jonathan F and Davidson, Bruce A and Knight, Paul R and Hakansson, Anders P and Pfeifer, Blaine A and Jones, Charles H},
  issn         = {1091-6490},
  language     = {eng},
  month        = {06},
  number       = {25},
  pages        = {6898--6903},
  publisher    = {ARRAY(0x9a710c0)},
  series       = {Proceedings of the National Academy of Sciences},
  title        = {Directed vaccination against pneumococcal disease},
  url          = {http://dx.doi.org/10.1073/pnas.1603007113},
  volume       = {113},
  year         = {2016},
}