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Complementarity-determining region (CDR) implantation : A theme of recombination

Söderlind, Eskil LU ; Ohlin, Mats LU and Carlsson, Roland LU (1999) In Immunotechnology 4(3-4). p.279-285
Abstract

A novel technology in the area of antibody engineering has been developed which allows for the creation of new types of antibody molecules. It is called complementarity-determining region (CDR) implantation and permits the random combination of CDR sequences formed in vivo into a single master framework. Thus, totally new gene combinations can be produced and used in selection processes. The result is a genetic variability which is extremely large, even exceeding the natural variability found in the immune system. In this commentary, CDR implantation is presented and the technology is discussed.

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author
organization
publishing date
type
Contribution to journal
publication status
published
keywords
Antibody engineering, CDR implantation, Complementarity-determining region, Genetic variation
in
Immunotechnology
volume
4
issue
3-4
pages
7 pages
publisher
Elsevier
external identifiers
  • Scopus:0033103199
ISSN
1380-2933
DOI
10.1016/S1380-2933(98)00027-X
language
English
LU publication?
yes
id
79b433e1-c0f9-4e10-b092-3e9503d4b425
date added to LUP
2016-04-19 14:04:18
date last changed
2016-04-22 13:32:47
@misc{79b433e1-c0f9-4e10-b092-3e9503d4b425,
  abstract     = {<p>A novel technology in the area of antibody engineering has been developed which allows for the creation of new types of antibody molecules. It is called complementarity-determining region (CDR) implantation and permits the random combination of CDR sequences formed in vivo into a single master framework. Thus, totally new gene combinations can be produced and used in selection processes. The result is a genetic variability which is extremely large, even exceeding the natural variability found in the immune system. In this commentary, CDR implantation is presented and the technology is discussed.</p>},
  author       = {Söderlind, Eskil and Ohlin, Mats and Carlsson, Roland},
  issn         = {1380-2933},
  keyword      = {Antibody engineering,CDR implantation,Complementarity-determining region,Genetic variation},
  language     = {eng},
  number       = {3-4},
  pages        = {279--285},
  publisher    = {ARRAY(0x8b3a288)},
  series       = {Immunotechnology},
  title        = {Complementarity-determining region (CDR) implantation : A theme of recombination},
  url          = {http://dx.doi.org/10.1016/S1380-2933(98)00027-X},
  volume       = {4},
  year         = {1999},
}