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Two allotypes of factor IX present in haemophilia B

Ljung, R. LU ; Wallmark, A. LU and Nilsson, Inga Marie (1986) In Scandinavian Journal of Haematology 37(5). p.411-416
Abstract

Factor IX antigen (IX:Ag) was measured with three different immunoradiometric assays (IRMAs) in 30 healthy people and 43 patients with haemophilia B of varying severity. Two of the IRMAs were based on monoclonal antibodies capable of differentiating between two genetically determined molecular variants of normal factor IX. Most patients with severe hemophilia B lacked demonstrable IX:Ag. The factor IX variant that is undetectable with one of the monoclonal antibodies used was present in 2 out of 6 families with moderate haemophilia B and in 1 out of 6 families with mild haemophilia B. The existence of allotypes of factor IX in hemophilia B may have practical implications for carrier detection and prenatal diagnosis.

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author
organization
publishing date
type
Contribution to journal
publication status
published
in
Scandinavian Journal of Haematology
volume
37
issue
5
pages
411 - 416
external identifiers
  • Scopus:0022862160
ISSN
0036-553X
DOI
10.1111/j.1600-0609.1986.tb02629.x
language
English
LU publication?
yes
id
7ccf36ba-d2f8-4f87-af16-9b0edcc4f6ef
date added to LUP
2016-10-26 13:54:58
date last changed
2016-11-15 10:08:16
@misc{7ccf36ba-d2f8-4f87-af16-9b0edcc4f6ef,
  abstract     = {<p>Factor IX antigen (IX:Ag) was measured with three different immunoradiometric assays (IRMAs) in 30 healthy people and 43 patients with haemophilia B of varying severity. Two of the IRMAs were based on monoclonal antibodies capable of differentiating between two genetically determined molecular variants of normal factor IX. Most patients with severe hemophilia B lacked demonstrable IX:Ag. The factor IX variant that is undetectable with one of the monoclonal antibodies used was present in 2 out of 6 families with moderate haemophilia B and in 1 out of 6 families with mild haemophilia B. The existence of allotypes of factor IX in hemophilia B may have practical implications for carrier detection and prenatal diagnosis.</p>},
  author       = {Ljung, R. and Wallmark, A. and Nilsson, Inga Marie},
  issn         = {0036-553X},
  language     = {eng},
  number       = {5},
  pages        = {411--416},
  series       = {Scandinavian Journal of Haematology},
  title        = {Two allotypes of factor IX present in haemophilia B},
  url          = {http://dx.doi.org/10.1111/j.1600-0609.1986.tb02629.x},
  volume       = {37},
  year         = {1986},
}