Advanced

Risk factor changes and incident atrial fibrillation among middle-aged men in the Malmö Preventive Project cohort

JOHNSON, LINDA LU ; Juhlin, Tord LU ; Engström, Gunnar LU and Nilsson, Peter LU (2015) In European Heart Journal Cardiovascular Pharmacotherapy 2(2). p.81-87
Abstract
Aims: To determine whether risk factor changes over 6 years were associated with the incidence of atrial fibrillation (AF)
among middle-aged men in the Malmo ̈ Preventive Project (MPP) cohort.
Methods and results: In total, 5633 men (mean age 47.0 years at baseline) underwent two screening examinations, separated by an average of
6 years. The annual rate at which systolic blood pressure (SBP), diastolic blood pressure (DBP), weight, fasting blood glucose (FBG), blood glucose at 2-h oral glucose tolerance test (OGTT), and screening spirometry values changed was
calculated and analysed in relation to incident AF, using Cox and competing risks regression to determine hazard ratios (HRs) and 95% confidence intervals (CIs). Mean... (More)
Aims: To determine whether risk factor changes over 6 years were associated with the incidence of atrial fibrillation (AF)
among middle-aged men in the Malmo ̈ Preventive Project (MPP) cohort.
Methods and results: In total, 5633 men (mean age 47.0 years at baseline) underwent two screening examinations, separated by an average of
6 years. The annual rate at which systolic blood pressure (SBP), diastolic blood pressure (DBP), weight, fasting blood glucose (FBG), blood glucose at 2-h oral glucose tolerance test (OGTT), and screening spirometry values changed was
calculated and analysed in relation to incident AF, using Cox and competing risks regression to determine hazard ratios (HRs) and 95% confidence intervals (CIs). Mean follow-up time + SD from rescreening was 22.3 + 7.4 years. Signifi-
cant associations were found between the annual increase of SBP (HR: 1.04, 95% CI: 1.01 – 1.07, P=0.003 per mmHg),DBP (HR: 1.06, 95% CI: 1.01 – 1.1, P=0.024 per mmHg), FBG (HR: 2.11, 95% CI: 1.44 – 3.12, P=0.0001 per mmol/L),
and weight (HR: 1.14, 95% CI: 1.05–1.24,=0.003 per kg) on the one hand and incident AF on the other, after full adjustment for baseline age, height, weight, SBP, FBG, smoking status, sedentary lifestyle, anti-hypertensive treatment,
screening year, and low socioeconomic status.
Conclusion: The age-adjusted annual rates of increase in SBP, DBP, weight, and FBG in mid-life are associated with AF incidence in men. This raises the question of whether preventive measur (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Heart Journal Cardiovascular Pharmacotherapy
volume
2
issue
2
pages
81 - 87
publisher
Oxford University Press
ISSN
2055-6837
DOI
10.1093/ehjcvp/pvv056
language
English
LU publication?
yes
id
7f632957-f09d-4a84-ba38-68a42dd429f5
date added to LUP
2016-09-27 11:43:04
date last changed
2016-09-28 03:00:02
@misc{7f632957-f09d-4a84-ba38-68a42dd429f5,
  abstract     = {Aims: To determine whether risk factor changes over 6 years were associated with the incidence of atrial fibrillation (AF)<br/>among middle-aged men in the Malmo ̈ Preventive Project (MPP) cohort.<br/>Methods and results: In total, 5633 men (mean age 47.0 years at baseline) underwent two screening examinations, separated by an average of<br/>6 years. The annual rate at which systolic blood pressure (SBP), diastolic blood pressure (DBP), weight, fasting blood glucose (FBG), blood glucose at 2-h oral glucose tolerance test (OGTT), and screening spirometry values changed was<br/>calculated and analysed in relation to incident AF, using Cox and competing risks regression to determine hazard ratios (HRs) and 95% confidence intervals (CIs). Mean follow-up time + SD from rescreening was 22.3 + 7.4 years. Signifi-<br/>cant associations were found between the annual increase of SBP (HR: 1.04, 95% CI: 1.01 – 1.07, P=0.003 per mmHg),DBP (HR: 1.06, 95% CI: 1.01 – 1.1, P=0.024 per mmHg), FBG (HR: 2.11, 95% CI: 1.44 – 3.12, P=0.0001 per mmol/L),<br/>and weight (HR: 1.14, 95% CI: 1.05–1.24,=0.003 per kg) on the one hand and incident AF on the other, after full adjustment for baseline age, height, weight, SBP, FBG, smoking status, sedentary lifestyle, anti-hypertensive treatment,<br/>screening year, and low socioeconomic status.<br/>Conclusion: The age-adjusted annual rates of increase in SBP, DBP, weight, and FBG in mid-life are associated with AF incidence in men. This raises the question of whether preventive measur},
  author       = {JOHNSON, LINDA and Juhlin, Tord and Engström, Gunnar and Nilsson, Peter},
  issn         = {2055-6837},
  language     = {eng},
  month        = {12},
  number       = {2},
  pages        = {81--87},
  publisher    = {ARRAY(0xc3357a8)},
  series       = {European Heart Journal Cardiovascular Pharmacotherapy},
  title        = {Risk factor changes and incident atrial fibrillation among middle-aged men in the Malmö Preventive Project cohort},
  url          = {http://dx.doi.org/10.1093/ehjcvp/pvv056},
  volume       = {2},
  year         = {2015},
}