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Filovirus transcription and replication

Brauburger, Kristina LU ; Deflubé, Laure R and Mühlberger, Elke (2015) In Biology and Pathogenesis of Rhabdo-and Filoviruses p.515-555
Abstract
Filoviruses belong to the group of nonsegmented, negative-sense (NNS) RNA viruses and are members of the order Mononegavirales along with the rhabdo-, paramyxo-, nyami-, and bornaviruses. Mononegaviruses share a general mechanism to replicate and transcribe their genomes, reflected in functionally homologous proteins and a similar genome structure. Although basic mechanisms are similar between rhabdo- and filoviral RNA synthesis, both virus families have developed distinct features. In this chapter, we describe the concepts underlying filovirus replication and transcription. We introduce the technologies that have enabled scientists to decipher the viral replication cycle and discuss recent insights in the regulation of filoviral RNA... (More)
Filoviruses belong to the group of nonsegmented, negative-sense (NNS) RNA viruses and are members of the order Mononegavirales along with the rhabdo-, paramyxo-, nyami-, and bornaviruses. Mononegaviruses share a general mechanism to replicate and transcribe their genomes, reflected in functionally homologous proteins and a similar genome structure. Although basic mechanisms are similar between rhabdo- and filoviral RNA synthesis, both virus families have developed distinct features. In this chapter, we describe the concepts underlying filovirus replication and transcription. We introduce the technologies that have enabled scientists to decipher the viral replication cycle and discuss recent insights in the regulation of filoviral RNA synthesis. We also highlight differences in RNA synthesis between filoviruses and two widely studied rhabdoviruses, vesicular stomatitis virus (VSV) of the Vesiculovirus genus and rabies virus (RABV) of the Lyssavirus genus. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
Biology and Pathogenesis of Rhabdo-and Filoviruses
editor
Pattnaik, A K and Whitt, M A
pages
515 - 555
publisher
World Scientific
external identifiers
  • Scopus:84988565665
ISBN
978-981-4635-33-2
978-981-4635-35-6
DOI
10.1142/9789814635349_0020
language
English
LU publication?
no
id
457d1689-1bb1-4e18-a9b3-a1f53b475e1d (old id 8726508)
alternative location
http://www.worldscientific.com/doi/pdf/10.1142/9789814635349_bmatter
date added to LUP
2016-03-03 12:28:14
date last changed
2016-10-13 04:44:05
@misc{457d1689-1bb1-4e18-a9b3-a1f53b475e1d,
  abstract     = {Filoviruses belong to the group of nonsegmented, negative-sense (NNS) RNA viruses and are members of the order Mononegavirales along with the rhabdo-, paramyxo-, nyami-, and bornaviruses. Mononegaviruses share a general mechanism to replicate and transcribe their genomes, reflected in functionally homologous proteins and a similar genome structure. Although basic mechanisms are similar between rhabdo- and filoviral RNA synthesis, both virus families have developed distinct features. In this chapter, we describe the concepts underlying filovirus replication and transcription. We introduce the technologies that have enabled scientists to decipher the viral replication cycle and discuss recent insights in the regulation of filoviral RNA synthesis. We also highlight differences in RNA synthesis between filoviruses and two widely studied rhabdoviruses, vesicular stomatitis virus (VSV) of the Vesiculovirus genus and rabies virus (RABV) of the Lyssavirus genus.},
  author       = {Brauburger, Kristina and Deflubé, Laure R and Mühlberger, Elke},
  editor       = {Pattnaik, A K and Whitt, M A},
  isbn         = {978-981-4635-33-2},
  language     = {eng},
  pages        = {515--555},
  publisher    = {ARRAY(0x94b4ea0)},
  series       = {Biology and Pathogenesis of Rhabdo-and Filoviruses},
  title        = {Filovirus transcription and replication},
  url          = {http://dx.doi.org/10.1142/9789814635349_0020},
  year         = {2015},
}