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Antikoagulantia efter akut ischemisk stroke med förmaksflimmer - Frågan om rätt tidpunkt för insättning kräver randomiserad klinisk prövning.

Terent, Andreas; Åsberg, Signild; Oldgren, Jonas; Hijazi, Ziad and Norrving, Bo LU (2016) In Läkartidningen 113.
Abstract
Early or delayed onset of oral anticoagulant therapy in patients with acute ischemic stroke with atrial fibrillation is an unsolved issue. Retrospectively, 294 patient records at two hospitals were scrutinized according to a protocol consisting of 20 items regarding choice of therapy (warfarin or NOAC), time for onset of therapy, CT findings of bleeding, capacity to swallow, and occurrence of clinical deterioration during the acute phase. Out of 249 patients who survived the acute phase, 116 (47%) patients were given a new prescription of warfarin or NOAC at discharge, while 43 (17 %) continued with anticoagulant therapy already prescribed before the onset of stroke. The median value for new prescriptions in relation to stroke admission... (More)
Early or delayed onset of oral anticoagulant therapy in patients with acute ischemic stroke with atrial fibrillation is an unsolved issue. Retrospectively, 294 patient records at two hospitals were scrutinized according to a protocol consisting of 20 items regarding choice of therapy (warfarin or NOAC), time for onset of therapy, CT findings of bleeding, capacity to swallow, and occurrence of clinical deterioration during the acute phase. Out of 249 patients who survived the acute phase, 116 (47%) patients were given a new prescription of warfarin or NOAC at discharge, while 43 (17 %) continued with anticoagulant therapy already prescribed before the onset of stroke. The median value for new prescriptions in relation to stroke admission was 5 days. The pattern was similar for warfarin and NOAC. Patients in whom anticoagulant therapy was started early were characterized by good capacity to swallow and no signs of bleeding on initial CT. The question »early or delayed onset of oral anticoagulant therapy after acute ischemic stroke with atrial fibrillation« needs to be tested in a randomized clinical trial. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Läkartidningen
volume
113
publisher
Sveriges Läkarförbund
external identifiers
  • PMID:26928683
  • Scopus:84959478268
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
7ff7dbae-ca02-46c2-9ad0-16c3d84e5fa5 (old id 8856756)
alternative location
http://www.lakartidningen.se/Klinik-och-vetenskap/Originalstudie/2016/03/Antikoagulantia-efter-akut-ischemisk-stroke-med-formaksflimmer/
http://www.ncbi.nlm.nih.gov/pubmed/26928683?dopt=Abstract
date added to LUP
2016-03-16 13:57:36
date last changed
2016-10-13 04:29:14
@misc{7ff7dbae-ca02-46c2-9ad0-16c3d84e5fa5,
  abstract     = {Early or delayed onset of oral anticoagulant therapy in patients with acute ischemic stroke with atrial fibrillation is an unsolved issue. Retrospectively, 294 patient records at two hospitals were scrutinized according to a protocol consisting of 20 items regarding choice of therapy (warfarin or NOAC), time for onset of therapy, CT findings of bleeding, capacity to swallow, and occurrence of clinical deterioration during the acute phase. Out of 249 patients who survived the acute phase, 116 (47%) patients were given a new prescription of warfarin or NOAC at discharge, while 43 (17 %) continued with anticoagulant therapy already prescribed before the onset of stroke. The median value for new prescriptions in relation to stroke admission was 5 days. The pattern was similar for warfarin and NOAC. Patients in whom anticoagulant therapy was started early were characterized by good capacity to swallow and no signs of bleeding on initial CT. The question »early or delayed onset of oral anticoagulant therapy after acute ischemic stroke with atrial fibrillation« needs to be tested in a randomized clinical trial.},
  author       = {Terent, Andreas and Åsberg, Signild and Oldgren, Jonas and Hijazi, Ziad and Norrving, Bo},
  issn         = {0023-7205},
  language     = {swe},
  publisher    = {ARRAY(0xa42c4b8)},
  series       = {Läkartidningen},
  title        = {Antikoagulantia efter akut ischemisk stroke med förmaksflimmer - Frågan om rätt tidpunkt för insättning kräver randomiserad klinisk prövning.},
  volume       = {113},
  year         = {2016},
}