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Sibling risk of hospitalization for heart failure – A nationwide study

Lindgren, Magnus P. LU ; Smith, J. Gustav; Li, Xinjun LU ; Sundquist, Jan LU ; Sundquist, Kristina LU and Zöller, Bengt LU (2016) In International Journal of Cardiology 223. p.379-384
Abstract

Background The familial risks of heart failure (HF) remain largely undetermined. This nationwide follow-up study aimed at determining risk of hospitalization for HF conferred by affected siblings. Methods and results Swedish Multi-generation Register data, with records of at least one full sibling available at start of follow-up, were linked to the Hospital Discharge Register data for 1987–2010. The oldest participants were aged 78 years in 2010. Relative risks, standardized incidence ratios (SIRs), of HF hospitalization were calculated for individuals with siblings hospitalized with HF compared with those whose siblings were not. Adjustments were made for common HF comorbidities, age, time period, socioeconomic status and region.... (More)

Background The familial risks of heart failure (HF) remain largely undetermined. This nationwide follow-up study aimed at determining risk of hospitalization for HF conferred by affected siblings. Methods and results Swedish Multi-generation Register data, with records of at least one full sibling available at start of follow-up, were linked to the Hospital Discharge Register data for 1987–2010. The oldest participants were aged 78 years in 2010. Relative risks, standardized incidence ratios (SIRs), of HF hospitalization were calculated for individuals with siblings hospitalized with HF compared with those whose siblings were not. Adjustments were made for common HF comorbidities, age, time period, socioeconomic status and region. During the 24 year follow-up (1987–2010) 23,212 individuals (7155 females), were hospitalized because of HF. From this total, 1121 had at least one full sibling hospitalized for HF. Sibling risks were generally similar for males and females. The SIR of HF hospitalization was 1.62 (95% confidence interval 1.54–1.70) for individuals with one affected sibling and 15.46 (12.82–18.50) for individuals with two affected siblings. The SIR conferred by one or more affected siblings was 2.67 (2.24–3.16) below the age of 50 years, 1.92 (1.75–2.10) between 50 and 59 years of age, 1.63 (1.52–1.76) between 60 and 69 years of age, and 1.54 (1.38–1.71) between 70 and 78 years of age. Spouses had low familial risks: SIR = 1.04 (1.03–1.06). Conclusions Familial factors are important risk factors in HF, with particularly high risks among individuals with two or more affected siblings and in early onset of HF.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Epidemiology, Genetics, Heart failure, Risk factors
in
International Journal of Cardiology
volume
223
pages
6 pages
publisher
Elsevier
external identifiers
  • Scopus:84982175072
ISSN
0167-5273
DOI
10.1016/j.ijcard.2016.08.067
language
English
LU publication?
yes
id
88573dee-a89e-400d-ba42-c9b8af4ef872
date added to LUP
2016-09-01 14:31:08
date last changed
2016-10-27 13:12:37
@misc{88573dee-a89e-400d-ba42-c9b8af4ef872,
  abstract     = {<p>Background The familial risks of heart failure (HF) remain largely undetermined. This nationwide follow-up study aimed at determining risk of hospitalization for HF conferred by affected siblings. Methods and results Swedish Multi-generation Register data, with records of at least one full sibling available at start of follow-up, were linked to the Hospital Discharge Register data for 1987–2010. The oldest participants were aged 78 years in 2010. Relative risks, standardized incidence ratios (SIRs), of HF hospitalization were calculated for individuals with siblings hospitalized with HF compared with those whose siblings were not. Adjustments were made for common HF comorbidities, age, time period, socioeconomic status and region. During the 24 year follow-up (1987–2010) 23,212 individuals (7155 females), were hospitalized because of HF. From this total, 1121 had at least one full sibling hospitalized for HF. Sibling risks were generally similar for males and females. The SIR of HF hospitalization was 1.62 (95% confidence interval 1.54–1.70) for individuals with one affected sibling and 15.46 (12.82–18.50) for individuals with two affected siblings. The SIR conferred by one or more affected siblings was 2.67 (2.24–3.16) below the age of 50 years, 1.92 (1.75–2.10) between 50 and 59 years of age, 1.63 (1.52–1.76) between 60 and 69 years of age, and 1.54 (1.38–1.71) between 70 and 78 years of age. Spouses had low familial risks: SIR = 1.04 (1.03–1.06). Conclusions Familial factors are important risk factors in HF, with particularly high risks among individuals with two or more affected siblings and in early onset of HF.</p>},
  author       = {Lindgren, Magnus P. and Smith, J. Gustav and Li, Xinjun and Sundquist, Jan and Sundquist, Kristina and Zöller, Bengt},
  issn         = {0167-5273},
  keyword      = {Epidemiology,Genetics,Heart failure,Risk factors},
  language     = {eng},
  month        = {11},
  pages        = {379--384},
  publisher    = {ARRAY(0x831e728)},
  series       = {International Journal of Cardiology},
  title        = {Sibling risk of hospitalization for heart failure – A nationwide study},
  url          = {http://dx.doi.org/10.1016/j.ijcard.2016.08.067},
  volume       = {223},
  year         = {2016},
}