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High risks of maternal and perinatal complications in singletons born after oocyte donation

Nejdet, Sarah; Bergh, Christina; Källén, Karin LU ; Wennerholm, Ulla-Britt and Thurin-Kjellberg, Ann (2016) In Acta Obstetricia et Gynecologica Scandinavica 95(8). p.86-879
Abstract

INTRODUCTION: Previous studies have shown an increased risk of obstetric complications in pregnancies after oocyte donation (OD). The present study includes all singletons born after OD during 10 years in Sweden.

MATERIAL AND METHODS: A retrospective cohort study that included data from all Swedish in vitro fertilization (IVF) clinics between 2003 and 2012 was performed. Data were cross-linked with the Swedish Medical Birth Registry. The study included 388 OD singletons, 26,696 IVF/ICSI singletons and 999,804 spontaneously conceived (SC) singletons. Adjusted odds ratio (AOR) was calculated with adjustment for relevant confounders.

RESULTS: Singleton OD pregnancies had a significantly increased risk of preeclampsia compared... (More)

INTRODUCTION: Previous studies have shown an increased risk of obstetric complications in pregnancies after oocyte donation (OD). The present study includes all singletons born after OD during 10 years in Sweden.

MATERIAL AND METHODS: A retrospective cohort study that included data from all Swedish in vitro fertilization (IVF) clinics between 2003 and 2012 was performed. Data were cross-linked with the Swedish Medical Birth Registry. The study included 388 OD singletons, 26,696 IVF/ICSI singletons and 999,804 spontaneously conceived (SC) singletons. Adjusted odds ratio (AOR) was calculated with adjustment for relevant confounders.

RESULTS: Singleton OD pregnancies had a significantly increased risk of preeclampsia compared to IVF (AOR 3.05; 95% CI 2.23-4.16) and SC (AOR 2.84; 95% CI 2.10-3.84), increased risk of postpartum hemorrhage (>1000 ml) compared to IVF (AOR 2.66; 95% CI 2.04-3.49) and SC (AOR 2.87; 95% CI 2.20-3.71), higher risk of preterm birth (<37) compared to IVF (AOR 1.79; 95% CI 1.30-2.46) and SC (AOR 1.58; 95% CI 1.15-2.16) and low birth weight (<2500 g) compared to IVF (AOR 1.67; 95% CI 1.15-2.42) and SC (AOR 1.46; 95% CI 1.01-2.11). The rate of large for gestational age was significantly increased in singletons born after OD with frozen cycles compared to fresh cycles (odds ratio 5.29, 95% CI 1.30-21.54).

CONCLUSIONS: Singleton pregnancies conceived after OD are associated with increased maternal and perinatal risks compared to IVF/ICSI pregnancies using the woman's own oocytes and with SC. This article is protected by copyright. All rights reserved.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Obstetricia et Gynecologica Scandinavica
volume
95
issue
8
pages
86 - 879
publisher
Wiley-Blackwell
external identifiers
  • Scopus:84978044956
ISSN
1600-0412
DOI
10.1111/aogs.12904
language
English
LU publication?
yes
id
8ea1b0c0-8603-4f0f-add7-4e0663c9b79c
date added to LUP
2016-05-03 14:30:25
date last changed
2016-11-06 04:37:23
@misc{8ea1b0c0-8603-4f0f-add7-4e0663c9b79c,
  abstract     = {<p>INTRODUCTION: Previous studies have shown an increased risk of obstetric complications in pregnancies after oocyte donation (OD). The present study includes all singletons born after OD during 10 years in Sweden.</p><p>MATERIAL AND METHODS: A retrospective cohort study that included data from all Swedish in vitro fertilization (IVF) clinics between 2003 and 2012 was performed. Data were cross-linked with the Swedish Medical Birth Registry. The study included 388 OD singletons, 26,696 IVF/ICSI singletons and 999,804 spontaneously conceived (SC) singletons. Adjusted odds ratio (AOR) was calculated with adjustment for relevant confounders.</p><p>RESULTS: Singleton OD pregnancies had a significantly increased risk of preeclampsia compared to IVF (AOR 3.05; 95% CI 2.23-4.16) and SC (AOR 2.84; 95% CI 2.10-3.84), increased risk of postpartum hemorrhage (&gt;1000 ml) compared to IVF (AOR 2.66; 95% CI 2.04-3.49) and SC (AOR 2.87; 95% CI 2.20-3.71), higher risk of preterm birth (&lt;37) compared to IVF (AOR 1.79; 95% CI 1.30-2.46) and SC (AOR 1.58; 95% CI 1.15-2.16) and low birth weight (&lt;2500 g) compared to IVF (AOR 1.67; 95% CI 1.15-2.42) and SC (AOR 1.46; 95% CI 1.01-2.11). The rate of large for gestational age was significantly increased in singletons born after OD with frozen cycles compared to fresh cycles (odds ratio 5.29, 95% CI 1.30-21.54).</p><p>CONCLUSIONS: Singleton pregnancies conceived after OD are associated with increased maternal and perinatal risks compared to IVF/ICSI pregnancies using the woman's own oocytes and with SC. This article is protected by copyright. All rights reserved.</p>},
  author       = {Nejdet, Sarah and Bergh, Christina and Källén, Karin and Wennerholm, Ulla-Britt and Thurin-Kjellberg, Ann},
  issn         = {1600-0412},
  language     = {eng},
  month        = {04},
  number       = {8},
  pages        = {86--879},
  publisher    = {ARRAY(0x8678488)},
  series       = {Acta Obstetricia et Gynecologica Scandinavica},
  title        = {High risks of maternal and perinatal complications in singletons born after oocyte donation},
  url          = {http://dx.doi.org/10.1111/aogs.12904},
  volume       = {95},
  year         = {2016},
}