Advanced

Survival of BRCA1 breast and ovarian cancer patients : a population-based study from southern Sweden

Jóhannsson, O T LU ; Ranstam, J LU ; Borg, Åke LU and Olsson, Håkan LU (1998) In Journal of Clinical Oncology 16(2). p.397-404
Abstract

PURPOSE: Recent studies indicate that BRCA1 breast and ovarian tumors may have an advantageous survival. In this population-based study, the survival of carriers of a mutated BRCA1 gene was investigated.

PATIENTS AND METHODS: The survival of 71 BRCA1-associated cancer patients (33 breast cancer, seven breast and ovarian cancer, and 31 ovarian cancer patients from 21 families with BRCA1 germline mutations) diagnosed after 1958 was compared with that of a population-based comparison group that consisted of all other invasive breast (n = 28,281) and ovarian (n = 7,011) cancers diagnosed during 1958 to 1995, as well as an age- and stage-matched control group.

RESULTS: No apparent survival advantage was found for BRCA1-associated... (More)

PURPOSE: Recent studies indicate that BRCA1 breast and ovarian tumors may have an advantageous survival. In this population-based study, the survival of carriers of a mutated BRCA1 gene was investigated.

PATIENTS AND METHODS: The survival of 71 BRCA1-associated cancer patients (33 breast cancer, seven breast and ovarian cancer, and 31 ovarian cancer patients from 21 families with BRCA1 germline mutations) diagnosed after 1958 was compared with that of a population-based comparison group that consisted of all other invasive breast (n = 28,281) and ovarian (n = 7,011) cancers diagnosed during 1958 to 1995, as well as an age- and stage-matched control group.

RESULTS: No apparent survival advantage was found for BRCA1-associated breast cancers upon direct comparison. After adjustment for age and calendar year of diagnosis, survival was equal to or worse than that of the comparison group (hazards ratio [HR], 1.5; 95% confidence interval [CI], 0.9 to 2.4). In comparison with an age- and stage-matched control group, survival again appeared equal or worse (HR, 1.5; 95% CI, 0.6 to 3.7). For BRCA1-associated ovarian cancers, an initial survival advantage was noted that disappeared with time. Due to this time dependency, multivariate analyses cannot adequately be analyzed. Compared with the age- and stage-matched control group, survival again appeared equal or worse (HR, 1.2; 95% CI, 0.5 to 2.8).

CONCLUSION: The results suggest that survival for carriers of a BRCA1 mutation may be similar, or worse than, that for breast and ovarian cancer in general. This finding is in accordance with the adverse histopathologic features observed in BRCA1 tumors and underlines the need for surveillance in families that carry a BRCA1 mutation.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Aged, Breast Neoplasms, Female, Genes, BRCA1, Germ-Line Mutation, Humans, Middle Aged, Ovarian Neoplasms, Survival Rate, Sweden
in
Journal of Clinical Oncology
volume
16
issue
2
pages
397 - 404
publisher
American Society of Clinical Oncology
external identifiers
  • Scopus:17444448154
ISSN
0732-183X
language
English
LU publication?
yes
id
9b9829ff-c48f-4821-be5b-774ed52a0ccf
date added to LUP
2016-09-18 12:40:06
date last changed
2016-11-20 04:35:44
@misc{9b9829ff-c48f-4821-be5b-774ed52a0ccf,
  abstract     = {<p>PURPOSE: Recent studies indicate that BRCA1 breast and ovarian tumors may have an advantageous survival. In this population-based study, the survival of carriers of a mutated BRCA1 gene was investigated.</p><p>PATIENTS AND METHODS: The survival of 71 BRCA1-associated cancer patients (33 breast cancer, seven breast and ovarian cancer, and 31 ovarian cancer patients from 21 families with BRCA1 germline mutations) diagnosed after 1958 was compared with that of a population-based comparison group that consisted of all other invasive breast (n = 28,281) and ovarian (n = 7,011) cancers diagnosed during 1958 to 1995, as well as an age- and stage-matched control group.</p><p>RESULTS: No apparent survival advantage was found for BRCA1-associated breast cancers upon direct comparison. After adjustment for age and calendar year of diagnosis, survival was equal to or worse than that of the comparison group (hazards ratio [HR], 1.5; 95% confidence interval [CI], 0.9 to 2.4). In comparison with an age- and stage-matched control group, survival again appeared equal or worse (HR, 1.5; 95% CI, 0.6 to 3.7). For BRCA1-associated ovarian cancers, an initial survival advantage was noted that disappeared with time. Due to this time dependency, multivariate analyses cannot adequately be analyzed. Compared with the age- and stage-matched control group, survival again appeared equal or worse (HR, 1.2; 95% CI, 0.5 to 2.8).</p><p>CONCLUSION: The results suggest that survival for carriers of a BRCA1 mutation may be similar, or worse than, that for breast and ovarian cancer in general. This finding is in accordance with the adverse histopathologic features observed in BRCA1 tumors and underlines the need for surveillance in families that carry a BRCA1 mutation.</p>},
  author       = {Jóhannsson, O T and Ranstam, J and Borg, Åke and Olsson, Håkan},
  issn         = {0732-183X},
  keyword      = {Adult,Aged,Breast Neoplasms,Female,Genes, BRCA1,Germ-Line Mutation,Humans,Middle Aged,Ovarian Neoplasms,Survival Rate,Sweden},
  language     = {eng},
  number       = {2},
  pages        = {397--404},
  publisher    = {ARRAY(0x882dd10)},
  series       = {Journal of Clinical Oncology},
  title        = {Survival of BRCA1 breast and ovarian cancer patients : a population-based study from southern Sweden},
  volume       = {16},
  year         = {1998},
}