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Blood transfusion at delivery and risk of subsequent malignant lymphoma in the mother

Anderson, H LU ; Brandt, L LU ; Ericson, A; Olsson, Håkan LU and Möller, Torgil LU (1998) In Vox Sanguinis 75(2). p.145-148
Abstract

BACKGROUND AND OBJECTIVES: Blood transfusion has been shown to be a risk factor for non-Hodgkin's lymphoma (NHL).

MATERIALS AND METHODS: In a cohort of 77,928 women with bleeding complications at delivery in the period of 1973-1986, subsequent NHL cases were identified and the number was compared with the number expected from national incidence rates. In a case-control study the proportion of transfused NHL cases was compared with the proportion of transfused controls.

RESULTS: The observed number of NHL in the cohort was 18 versus 22.0 expected. Information on transfusion was obtained for 15 of the NHL cases and none (0%) was transfused versus 32 out of 136 controls (23%).

CONCLUSIONS: Blood transfusion at delivery is... (More)

BACKGROUND AND OBJECTIVES: Blood transfusion has been shown to be a risk factor for non-Hodgkin's lymphoma (NHL).

MATERIALS AND METHODS: In a cohort of 77,928 women with bleeding complications at delivery in the period of 1973-1986, subsequent NHL cases were identified and the number was compared with the number expected from national incidence rates. In a case-control study the proportion of transfused NHL cases was compared with the proportion of transfused controls.

RESULTS: The observed number of NHL in the cohort was 18 versus 22.0 expected. Information on transfusion was obtained for 15 of the NHL cases and none (0%) was transfused versus 32 out of 136 controls (23%).

CONCLUSIONS: Blood transfusion at delivery is not a risk factor for NHL. The immune tolerance induced by pregnancy may reduce the risk of NHL associated with the transfusion of allogeneic blood cells.

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Adult, Blood Transfusion, Case-Control Studies, Cohort Studies, Delivery, Obstetric, Female, Hodgkin Disease, Humans, Incidence, Lymphoma, Non-Hodgkin, Postpartum Hemorrhage, Pregnancy, Risk Factors, Sweden
in
Vox Sanguinis
volume
75
issue
2
pages
145 - 148
publisher
Wiley-Blackwell
external identifiers
  • Scopus:0031721127
ISSN
0042-9007
language
English
LU publication?
yes
id
cbb74510-c64f-437f-a9fe-45882354d6fb
date added to LUP
2016-09-18 12:35:27
date last changed
2016-10-13 05:13:44
@misc{cbb74510-c64f-437f-a9fe-45882354d6fb,
  abstract     = {<p>BACKGROUND AND OBJECTIVES: Blood transfusion has been shown to be a risk factor for non-Hodgkin's lymphoma (NHL).</p><p>MATERIALS AND METHODS: In a cohort of 77,928 women with bleeding complications at delivery in the period of 1973-1986, subsequent NHL cases were identified and the number was compared with the number expected from national incidence rates. In a case-control study the proportion of transfused NHL cases was compared with the proportion of transfused controls.</p><p>RESULTS: The observed number of NHL in the cohort was 18 versus 22.0 expected. Information on transfusion was obtained for 15 of the NHL cases and none (0%) was transfused versus 32 out of 136 controls (23%).</p><p>CONCLUSIONS: Blood transfusion at delivery is not a risk factor for NHL. The immune tolerance induced by pregnancy may reduce the risk of NHL associated with the transfusion of allogeneic blood cells.</p>},
  author       = {Anderson, H and Brandt, L and Ericson, A and Olsson, Håkan and Möller, Torgil},
  issn         = {0042-9007},
  keyword      = {Adult,Blood Transfusion,Case-Control Studies,Cohort Studies,Delivery, Obstetric,Female,Hodgkin Disease,Humans,Incidence,Lymphoma, Non-Hodgkin,Postpartum Hemorrhage,Pregnancy,Risk Factors,Sweden},
  language     = {eng},
  number       = {2},
  pages        = {145--148},
  publisher    = {ARRAY(0x827e4d8)},
  series       = {Vox Sanguinis},
  title        = {Blood transfusion at delivery and risk of subsequent malignant lymphoma in the mother},
  volume       = {75},
  year         = {1998},
}