Assessment of inactive, active and mixed atherosclerotic plaques by 18F-FDG-PET; an age group-based correlation with cardiovascular risk factors
(2009) In International Journal of Cardiovascular Imaging 25(2). p.40-133- Abstract
PURPOSE: The aim of this study was to assess the atherosclerotic plaques in a large asymptomatic population stratified based on age and sex.
METHODS: [18F]-2-fluoro-2-deoxy-D-glucose (FDG)-PET/CT of 100 men and 100 women, divided in four age groups were examined to assess FDG-accumulating active, calcified inactive and mixed atherosclerotic plaques in eight defined vessel segments.
RESULTS: There was a high correlation between the total number of cardiovascular risk factors and the number of FDG-accumulating active plaques as well as the number of calcified inactive plaques. There was a significant difference in the number of plaques between all age-groups except for active plaques in age groups 60-70 and 80-90... (More)
PURPOSE: The aim of this study was to assess the atherosclerotic plaques in a large asymptomatic population stratified based on age and sex.
METHODS: [18F]-2-fluoro-2-deoxy-D-glucose (FDG)-PET/CT of 100 men and 100 women, divided in four age groups were examined to assess FDG-accumulating active, calcified inactive and mixed atherosclerotic plaques in eight defined vessel segments.
RESULTS: There was a high correlation between the total number of cardiovascular risk factors and the number of FDG-accumulating active plaques as well as the number of calcified inactive plaques. There was a significant difference in the number of plaques between all age-groups except for active plaques in age groups 60-70 and 80-90 years.
CONCLUSIONS: There is a correlation between the number of cardiovascular risk factors and the number of FDG-accumulating atherosclerotic lesions in this patient material. Statin-treatment was associated with significantly lower numbers of active plaques.
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- author
- Wassélius, Johan LU ; Larsson, Stig LU ; Sundin, Anders and Jacobsson, Hans
- publishing date
- 2009-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult, Age Factors, Aged, Aged, 80 and over, Atherosclerosis, Cardiovascular Diseases, Female, Fluorodeoxyglucose F18, Humans, Male, Middle Aged, Positron-Emission Tomography, Radiographic Image Interpretation, Computer-Assisted, Radiopharmaceuticals, Risk Factors, Tomography, X-Ray Computed, Journal Article, Research Support, Non-U.S. Gov't
- in
- International Journal of Cardiovascular Imaging
- volume
- 25
- issue
- 2
- pages
- 8 pages
- publisher
- Springer
- external identifiers
-
- scopus:59149090701
- pmid:18784986
- ISSN
- 1875-8312
- DOI
- 10.1007/s10554-008-9366-5
- language
- English
- LU publication?
- no
- id
- d2f8a288-522c-40a9-b59b-77cf23a5906a
- date added to LUP
- 2016-10-14 09:58:21
- date last changed
- 2024-09-06 23:46:57
@article{d2f8a288-522c-40a9-b59b-77cf23a5906a, abstract = {{<p>PURPOSE: The aim of this study was to assess the atherosclerotic plaques in a large asymptomatic population stratified based on age and sex.</p><p>METHODS: [18F]-2-fluoro-2-deoxy-D-glucose (FDG)-PET/CT of 100 men and 100 women, divided in four age groups were examined to assess FDG-accumulating active, calcified inactive and mixed atherosclerotic plaques in eight defined vessel segments.</p><p>RESULTS: There was a high correlation between the total number of cardiovascular risk factors and the number of FDG-accumulating active plaques as well as the number of calcified inactive plaques. There was a significant difference in the number of plaques between all age-groups except for active plaques in age groups 60-70 and 80-90 years.</p><p>CONCLUSIONS: There is a correlation between the number of cardiovascular risk factors and the number of FDG-accumulating atherosclerotic lesions in this patient material. Statin-treatment was associated with significantly lower numbers of active plaques.</p>}}, author = {{Wassélius, Johan and Larsson, Stig and Sundin, Anders and Jacobsson, Hans}}, issn = {{1875-8312}}, keywords = {{Adult; Age Factors; Aged; Aged, 80 and over; Atherosclerosis; Cardiovascular Diseases; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiographic Image Interpretation, Computer-Assisted; Radiopharmaceuticals; Risk Factors; Tomography, X-Ray Computed; Journal Article; Research Support, Non-U.S. Gov't}}, language = {{eng}}, number = {{2}}, pages = {{40--133}}, publisher = {{Springer}}, series = {{International Journal of Cardiovascular Imaging}}, title = {{Assessment of inactive, active and mixed atherosclerotic plaques by 18F-FDG-PET; an age group-based correlation with cardiovascular risk factors}}, url = {{http://dx.doi.org/10.1007/s10554-008-9366-5}}, doi = {{10.1007/s10554-008-9366-5}}, volume = {{25}}, year = {{2009}}, }