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Association of erythroid transcription factors : complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1

Osada, H; Grutz, G; Axelson, H LU ; Forster, A and Rabbitts, T H (1995) In Proceedings of the National Academy of Sciences 92(21). p.9-9585
Abstract

The RBTN2 LIM-domain protein, originally identified as an oncogenic protein in human T-cell leukemia, is essential for erythropoiesis. A possible role for RBTN2 in transcription during erythropoiesis has been investigated. Direct interaction of the RBTN2 protein was observed in vivo and in vitro with the GATA1 or -2 zinc-finger transcription factors, as well as with the basic helix-loop-helix protein TAL1. By using mammalian two-hybrid analysis, complexes involving RBTN2, TAL1, and GATA1, together with E47, the basic helix-loop-helix heterodimerization partner of TAL1, could be demonstrated. Thus, a molecular link exists between three proteins crucial for erythropoiesis, and the data suggest that variations in amounts of complexes... (More)

The RBTN2 LIM-domain protein, originally identified as an oncogenic protein in human T-cell leukemia, is essential for erythropoiesis. A possible role for RBTN2 in transcription during erythropoiesis has been investigated. Direct interaction of the RBTN2 protein was observed in vivo and in vitro with the GATA1 or -2 zinc-finger transcription factors, as well as with the basic helix-loop-helix protein TAL1. By using mammalian two-hybrid analysis, complexes involving RBTN2, TAL1, and GATA1, together with E47, the basic helix-loop-helix heterodimerization partner of TAL1, could be demonstrated. Thus, a molecular link exists between three proteins crucial for erythropoiesis, and the data suggest that variations in amounts of complexes involving RBTN2, TAL1, and GATA1 could be important for erythroid differentiation.

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keywords
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Animals, Basic Helix-Loop-Helix Transcription Factors, DNA-Binding Proteins, Erythroid-Specific DNA-Binding Factors, Erythropoiesis, GATA1 Transcription Factor, Helix-Loop-Helix Motifs, Homeodomain Proteins, LIM Domain Proteins, Leukemia, Erythroblastic, Acute, Metalloproteins, Mice, Molecular Sequence Data, Protein Binding, Proto-Oncogene Proteins, Recombinant Proteins, TCF Transcription Factors, Transcription Factor 7-Like 1 Protein, Transcription Factors, Tumor Cells, Cultured, Zinc Fingers
in
Proceedings of the National Academy of Sciences
volume
92
issue
21
pages
5 pages
publisher
National Academy of Sciences
external identifiers
  • Scopus:0028799441
ISSN
0027-8424
language
English
LU publication?
yes
id
dc58d7ea-9056-4326-be29-49aef186030b
date added to LUP
2016-08-09 09:13:42
date last changed
2016-08-10 04:00:18
@misc{dc58d7ea-9056-4326-be29-49aef186030b,
  abstract     = {<p>The RBTN2 LIM-domain protein, originally identified as an oncogenic protein in human T-cell leukemia, is essential for erythropoiesis. A possible role for RBTN2 in transcription during erythropoiesis has been investigated. Direct interaction of the RBTN2 protein was observed in vivo and in vitro with the GATA1 or -2 zinc-finger transcription factors, as well as with the basic helix-loop-helix protein TAL1. By using mammalian two-hybrid analysis, complexes involving RBTN2, TAL1, and GATA1, together with E47, the basic helix-loop-helix heterodimerization partner of TAL1, could be demonstrated. Thus, a molecular link exists between three proteins crucial for erythropoiesis, and the data suggest that variations in amounts of complexes involving RBTN2, TAL1, and GATA1 could be important for erythroid differentiation.</p>},
  author       = {Osada, H and Grutz, G and Axelson, H and Forster, A and Rabbitts, T H},
  issn         = {0027-8424},
  keyword      = {Adaptor Proteins, Signal Transducing,Amino Acid Sequence,Animals,Basic Helix-Loop-Helix Transcription Factors,DNA-Binding Proteins,Erythroid-Specific DNA-Binding Factors,Erythropoiesis,GATA1 Transcription Factor,Helix-Loop-Helix Motifs,Homeodomain Proteins,LIM Domain Proteins,Leukemia, Erythroblastic, Acute,Metalloproteins,Mice,Molecular Sequence Data,Protein Binding,Proto-Oncogene Proteins,Recombinant Proteins,TCF Transcription Factors,Transcription Factor 7-Like 1 Protein,Transcription Factors,Tumor Cells, Cultured,Zinc Fingers},
  language     = {eng},
  month        = {10},
  number       = {21},
  pages        = {9--9585},
  publisher    = {ARRAY(0x523d950)},
  series       = {Proceedings of the National Academy of Sciences},
  title        = {Association of erythroid transcription factors : complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1},
  volume       = {92},
  year         = {1995},
}