Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Stress granules : emerging players in neurodegenerative diseases

Yuan, Lin ; Mao, Li Hong ; Huang, Yong Ye ; Outeiro, Tiago F. ; Li, Wen LU ; Vieira, Tuane C.R.G. and Li, Jia Yi LU (2025) In Translational Neurodegeneration 14(1).
Abstract

Stress granules (SGs) are membraneless organelles formed in the cellular cytoplasm under stressful conditions through liquid–liquid phase separation (LLPS). SG assembly can be both dependent and independent of the eIF2α pathway, whereas cellular protein quality control systems mediate SG disassembly. Chaperones and specific domains of RNA-binding proteins strongly contribute to the regulation SG dynamics. Chronic stress, arising in association with aging, may promote persistent SGs that are difficult to disassemble, thereby acting as a potential pathological nidus for protein aggregation in neurodegenerative diseases (NDDs). In this review, we discuss the dynamics of SGs and the factors involved with SG assembly and disassembly. We also... (More)

Stress granules (SGs) are membraneless organelles formed in the cellular cytoplasm under stressful conditions through liquid–liquid phase separation (LLPS). SG assembly can be both dependent and independent of the eIF2α pathway, whereas cellular protein quality control systems mediate SG disassembly. Chaperones and specific domains of RNA-binding proteins strongly contribute to the regulation SG dynamics. Chronic stress, arising in association with aging, may promote persistent SGs that are difficult to disassemble, thereby acting as a potential pathological nidus for protein aggregation in neurodegenerative diseases (NDDs). In this review, we discuss the dynamics of SGs and the factors involved with SG assembly and disassembly. We also highlight the relationship among LLPS, SGs, and the pathogenesis of different NDDs. More importantly, we summarize SG assembly-disassembly, which may be a double-edged sword in the pathophysiology of NDDs. This review aims to provide new insights into the biology and pathology of LLPS, SGs, and NDDs.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Liquid–liquid phase separation, Neurodegenerative disease, RNA-binding protein, Stress granules
in
Translational Neurodegeneration
volume
14
issue
1
article number
22
publisher
BioMed Central (BMC)
external identifiers
  • scopus:105004738191
  • pmid:40355949
ISSN
2047-9158
DOI
10.1186/s40035-025-00482-9
language
English
LU publication?
yes
id
02aab798-fc1f-402d-b724-9bf975e2bb06
date added to LUP
2025-07-14 11:17:36
date last changed
2025-07-15 03:00:10
@article{02aab798-fc1f-402d-b724-9bf975e2bb06,
  abstract     = {{<p>Stress granules (SGs) are membraneless organelles formed in the cellular cytoplasm under stressful conditions through liquid–liquid phase separation (LLPS). SG assembly can be both dependent and independent of the eIF2α pathway, whereas cellular protein quality control systems mediate SG disassembly. Chaperones and specific domains of RNA-binding proteins strongly contribute to the regulation SG dynamics. Chronic stress, arising in association with aging, may promote persistent SGs that are difficult to disassemble, thereby acting as a potential pathological nidus for protein aggregation in neurodegenerative diseases (NDDs). In this review, we discuss the dynamics of SGs and the factors involved with SG assembly and disassembly. We also highlight the relationship among LLPS, SGs, and the pathogenesis of different NDDs. More importantly, we summarize SG assembly-disassembly, which may be a double-edged sword in the pathophysiology of NDDs. This review aims to provide new insights into the biology and pathology of LLPS, SGs, and NDDs.</p>}},
  author       = {{Yuan, Lin and Mao, Li Hong and Huang, Yong Ye and Outeiro, Tiago F. and Li, Wen and Vieira, Tuane C.R.G. and Li, Jia Yi}},
  issn         = {{2047-9158}},
  keywords     = {{Liquid–liquid phase separation; Neurodegenerative disease; RNA-binding protein; Stress granules}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Translational Neurodegeneration}},
  title        = {{Stress granules : emerging players in neurodegenerative diseases}},
  url          = {{http://dx.doi.org/10.1186/s40035-025-00482-9}},
  doi          = {{10.1186/s40035-025-00482-9}},
  volume       = {{14}},
  year         = {{2025}},
}