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Chronic Airflow Limitation, Lower Respiratory Symptoms, COPD and Chronic Rhinosinusitis in a Middle-Aged Population : The Swedish CArdioPulmonary bioImage Study (SCAPIS). A Link Between the Lower and Upper Airways

Andersson, Anders ; Bergqvist, Joel ; Schiöler, Linus ; Bossios, Apostolos ; Farnebo, Lovisa ; Holmlund, Thorbjörn ; Janson, Christer ; Keceli, Sumru ; Ljunggren, Mirjam and Malinovschi, Andrei , et al. (2025) In International Journal of COPD 20. p.273-286
Abstract

Purpose: Chronic rhinosinusitis (CRS) is related to asthma and chronic obstructive pulmonary disease (COPD). However, combined data on CRS, pulmonary function, lower airway symptoms, and cigarette smoking from the general population are lacking. The current study investigates the relationships between CRS and chronic airflow limitation (CAL), lower airway symptoms and COPD in a middle-aged population of ever-smokers and never-smokers. Patients and Methods: All subjects from the Swedish CArdioPulmonary bioImage Study (SCAPIS) were included. Subjects underwent spirometry after bronchodilation. Chronic airflow limitation was defined as FEV1/FVC ratio <0.7. Computed tomography imaging of the thorax was performed to detect the... (More)

Purpose: Chronic rhinosinusitis (CRS) is related to asthma and chronic obstructive pulmonary disease (COPD). However, combined data on CRS, pulmonary function, lower airway symptoms, and cigarette smoking from the general population are lacking. The current study investigates the relationships between CRS and chronic airflow limitation (CAL), lower airway symptoms and COPD in a middle-aged population of ever-smokers and never-smokers. Patients and Methods: All subjects from the Swedish CArdioPulmonary bioImage Study (SCAPIS) were included. Subjects underwent spirometry after bronchodilation. Chronic airflow limitation was defined as FEV1/FVC ratio <0.7. Computed tomography imaging of the thorax was performed to detect the presence of emphysema, and the subjects answered a comprehensive questionnaire on CRS, lower airway symptoms, asthma, chronic bronchitis, and cigarette smoking habits. Results: In total, 30,154 adult subjects in the age range of 50–64 years were included. The prevalence of CRS was 5.6%. CRS was more-prevalent among subjects in the following categories: CAL (7.6%), lower airway symptoms (15.7%), current smokers (8.2%), asthma (13.6%), never-smokers and ever-smokers with COPD (17.6% and 15.3%, respectively), emphysema (6.7%), and chronic bronchitis (24.5%). In the adjusted regression model, CRS was significantly associated with CAL (OR 1.40), lower airway symptoms (OR 4.59), chronic bronchitis (OR 6.48), asthma (OR 3.08), and COPD (OR 3.10). Conclusion: In this national, randomly chosen population sample of more than 30,000 middle-aged men and women, CRS is associated with CAL, lower airway symptoms, chronic bronchitis, asthma, and COPD. In patients with CRS and in patients with lower airway inflammation, it is important to consider the inflammatory status of the entire airway system.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
asthma, chronic bronchitis, chronic obstructive pulmonary disease, CRS, emphysema, smoking
in
International Journal of COPD
volume
20
pages
14 pages
publisher
Dove Medical Press Ltd.
external identifiers
  • pmid:39959845
  • scopus:85218461955
ISSN
1176-9106
DOI
10.2147/COPD.S493219
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2025 Andersson et al.
id
02e21f1b-f187-4423-8351-f183642dc6fb
date added to LUP
2025-07-03 09:36:36
date last changed
2025-07-04 03:00:02
@article{02e21f1b-f187-4423-8351-f183642dc6fb,
  abstract     = {{<p>Purpose: Chronic rhinosinusitis (CRS) is related to asthma and chronic obstructive pulmonary disease (COPD). However, combined data on CRS, pulmonary function, lower airway symptoms, and cigarette smoking from the general population are lacking. The current study investigates the relationships between CRS and chronic airflow limitation (CAL), lower airway symptoms and COPD in a middle-aged population of ever-smokers and never-smokers. Patients and Methods: All subjects from the Swedish CArdioPulmonary bioImage Study (SCAPIS) were included. Subjects underwent spirometry after bronchodilation. Chronic airflow limitation was defined as FEV<sub>1</sub>/FVC ratio &lt;0.7. Computed tomography imaging of the thorax was performed to detect the presence of emphysema, and the subjects answered a comprehensive questionnaire on CRS, lower airway symptoms, asthma, chronic bronchitis, and cigarette smoking habits. Results: In total, 30,154 adult subjects in the age range of 50–64 years were included. The prevalence of CRS was 5.6%. CRS was more-prevalent among subjects in the following categories: CAL (7.6%), lower airway symptoms (15.7%), current smokers (8.2%), asthma (13.6%), never-smokers and ever-smokers with COPD (17.6% and 15.3%, respectively), emphysema (6.7%), and chronic bronchitis (24.5%). In the adjusted regression model, CRS was significantly associated with CAL (OR 1.40), lower airway symptoms (OR 4.59), chronic bronchitis (OR 6.48), asthma (OR 3.08), and COPD (OR 3.10). Conclusion: In this national, randomly chosen population sample of more than 30,000 middle-aged men and women, CRS is associated with CAL, lower airway symptoms, chronic bronchitis, asthma, and COPD. In patients with CRS and in patients with lower airway inflammation, it is important to consider the inflammatory status of the entire airway system.</p>}},
  author       = {{Andersson, Anders and Bergqvist, Joel and Schiöler, Linus and Bossios, Apostolos and Farnebo, Lovisa and Holmlund, Thorbjörn and Janson, Christer and Keceli, Sumru and Ljunggren, Mirjam and Malinovschi, Andrei and Memarian, Ensieh and Nihlén, Ulf and Nilsson, Peter M. and Pesonen, Ida and Sjöström, Marcus and Stenfors, Nikolai and Sundbom, Fredrik and Werner, Mimmi and Torén, Kjell and Sköld, Magnus and Hellgren, Johan}},
  issn         = {{1176-9106}},
  keywords     = {{asthma; chronic bronchitis; chronic obstructive pulmonary disease; CRS; emphysema; smoking}},
  language     = {{eng}},
  pages        = {{273--286}},
  publisher    = {{Dove Medical Press Ltd.}},
  series       = {{International Journal of COPD}},
  title        = {{Chronic Airflow Limitation, Lower Respiratory Symptoms, COPD and Chronic Rhinosinusitis in a Middle-Aged Population : The Swedish CArdioPulmonary bioImage Study (SCAPIS). A Link Between the Lower and Upper Airways}},
  url          = {{http://dx.doi.org/10.2147/COPD.S493219}},
  doi          = {{10.2147/COPD.S493219}},
  volume       = {{20}},
  year         = {{2025}},
}