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Characterization of bioactivity and phytochemical composition with toxicity studies of different Opuntia dillenii extracts from Morocco

Katanić, Jelena ; Yousfi, Fatima ; Caruso, Marisa Carmela ; Matić, Sanja ; Monti, Daria Maria ; Loukili, El Hassania ; Boroja, Tatjana ; Mihailović, Vladimir ; Galgano, Fernanda and Imbimbo, Paola , et al. (2019) In Food Bioscience 30.
Abstract

The phytochemical composition, in vitro antioxidant and antimicrobial activities, cytotoxicity and antigenotoxicity of fruit extracts of Opuntia dillenii were studied. The phytochemical composition was evaluated using HPLC, GC-MS and UV–Vis spectrophotometry. Spectrophotometrical methods were used to estimate the antioxidant potential. Antimicrobial activity was determined using a microdilution method. The cytotoxic effects of the extracts were evaluated using the MTT assay. In vitro DNA-protective activity against hydroxyl radical-induced DNA damage was also determined. The results showed that polar extracts of O. dillenii had a significant amount of phenolic compounds, including flavonoids, whereas non-polar extracts had mostly... (More)

The phytochemical composition, in vitro antioxidant and antimicrobial activities, cytotoxicity and antigenotoxicity of fruit extracts of Opuntia dillenii were studied. The phytochemical composition was evaluated using HPLC, GC-MS and UV–Vis spectrophotometry. Spectrophotometrical methods were used to estimate the antioxidant potential. Antimicrobial activity was determined using a microdilution method. The cytotoxic effects of the extracts were evaluated using the MTT assay. In vitro DNA-protective activity against hydroxyl radical-induced DNA damage was also determined. The results showed that polar extracts of O. dillenii had a significant amount of phenolic compounds, including flavonoids, whereas non-polar extracts had mostly terpenoids and fatty acid derivatives. Moreover, several extracts showed good antioxidant and antimicrobial activities, with low cytotoxicity and significant DNA-protective effects. These results showed that the extracts of O. dillenii have promising bioactivity and further studies on the potential application in different areas of food and health might be beneficial.

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publishing date
type
Contribution to journal
publication status
published
keywords
Cactus, Opuntia dillenii, Pear bush, Polyphenolics, Prickly pear
in
Food Bioscience
volume
30
article number
100410
publisher
Elsevier
external identifiers
  • scopus:85065641179
ISSN
2212-4292
DOI
10.1016/j.fbio.2019.04.011
language
English
LU publication?
no
additional info
Publisher Copyright: © 2019 Elsevier Ltd
id
040c76b6-d24e-4559-83fc-02fb3e8969aa
date added to LUP
2025-01-21 14:44:44
date last changed
2025-01-21 16:11:18
@article{040c76b6-d24e-4559-83fc-02fb3e8969aa,
  abstract     = {{<p>The phytochemical composition, in vitro antioxidant and antimicrobial activities, cytotoxicity and antigenotoxicity of fruit extracts of Opuntia dillenii were studied. The phytochemical composition was evaluated using HPLC, GC-MS and UV–Vis spectrophotometry. Spectrophotometrical methods were used to estimate the antioxidant potential. Antimicrobial activity was determined using a microdilution method. The cytotoxic effects of the extracts were evaluated using the MTT assay. In vitro DNA-protective activity against hydroxyl radical-induced DNA damage was also determined. The results showed that polar extracts of O. dillenii had a significant amount of phenolic compounds, including flavonoids, whereas non-polar extracts had mostly terpenoids and fatty acid derivatives. Moreover, several extracts showed good antioxidant and antimicrobial activities, with low cytotoxicity and significant DNA-protective effects. These results showed that the extracts of O. dillenii have promising bioactivity and further studies on the potential application in different areas of food and health might be beneficial.</p>}},
  author       = {{Katanić, Jelena and Yousfi, Fatima and Caruso, Marisa Carmela and Matić, Sanja and Monti, Daria Maria and Loukili, El Hassania and Boroja, Tatjana and Mihailović, Vladimir and Galgano, Fernanda and Imbimbo, Paola and Petruk, Ganna and Bouhrim, Mohamed and Bnouham, Mohamed and Ramdani, Mohammed}},
  issn         = {{2212-4292}},
  keywords     = {{Cactus; Opuntia dillenii; Pear bush; Polyphenolics; Prickly pear}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Food Bioscience}},
  title        = {{Characterization of bioactivity and phytochemical composition with toxicity studies of different Opuntia dillenii extracts from Morocco}},
  url          = {{http://dx.doi.org/10.1016/j.fbio.2019.04.011}},
  doi          = {{10.1016/j.fbio.2019.04.011}},
  volume       = {{30}},
  year         = {{2019}},
}